In this paper, we investigate the possible deviations of the cosmic distance duality relation (CDDR) using the combination of the largest SNe Ia (Pantheon) and compact radio quasar (QSO) samples through two model-independent approaches. The deviation of CDDR is written as DL(z)/DA(z)(1+z)−2=η(z) and η(z)=eτ(z)/2, with the parameterizations of F1 (τ(z)=2ϵ1z) and F2 (τ(z)=(1+z)2ϵ2−1). Furthermore, in order to compare the two resulting distances, two cosmological-model-independent methods, i.e., the nearby SNe Ia method and the GP method are employed to match the two distinct data at the same redshift. Our findings indicate that, compared with the results obtained in the literature, there is an improvement in precision when the latest SNe Ia and QSO samples are used. Specially, in the framework of nearby SNe Ia method, the CDDR would be constrained at the precision of Δϵ1=0.013 in Model F1 and Δϵ2=0.018 in Model F2. Regarding the GP method, one observes that a larger data size would produce more stringent constraints on the CDDR parameters. Therefore, accompanied by further developments in cosmological observations and the analysis methods, our analysis provides an insight into the evidence for unaccounted opacity sources at an earlier stage of the universe, or at the very least the new physics involved.