Air-conditioning energy consumption accounts for a significant proportion of the total energy usage in large commercial buildings. This study utilizes computational fluid dynamics (CFD) to examine the airflow distribution in a cigarette factory with a high ceiling. Numerical simulations were performed to assess the effectiveness of various air supply methods. Using FLUENT, the researchers analyzed the uniformity of airflow, temperature and humidity fields under summer conditions. The findings indicate that employing an upper supply and lower return air method can decrease air-conditioning energy consumption by 7.25%. Field measurements were carried out to validate the numerical simulations, with the measured values used as initial parameters. The average deviation between the measured and simulated temperature and humidity in critical work areas was within 2%. The comparative analysis of the simulation and measurement results confirms the reliability and effectiveness of airflow organization simulations in large commercial buildings. These results offer a scientific foundation and computational guidance for designing and implementing energy-efficient upgrades to air-conditioning systems in similar industrial facilities.