Aims & Objective: To evaluate if the implants can be osseointegrated in regenerated bone of patients who had large bony defects following odontogenic cyst enucleation. Material & Methods: A total of five patients were chosen for the study, implants were placed one year after surgical cyst enucleation The patients were assessed clinically and radiologically periodically i.e. every month , till 6 months after placement of implant . The success criteria included absence of any sign of periimplant inflammation , clinical mobility of the implant and abutment and finally absence of any peri implant radiolucency when seen on the radiograph. Results: A total of 15 implants were placed in five patients having regenerated bone with 93.3 % osseointegration . One patient showed failure i.e. implant mobility fifteen days after placement. The failure was attributed to poor quality of regenerated bone. Conclusion: By the findings of this study, we can safely conclude that implants can be successfully osseointegrated in regenerated bone , however poor quality of regenerated bone is the main cause of failure. However studies with larger sample size and concurrent HBO therapy to accelerate bone healing can be done in future.