Large Amount Of New Information Research Articles

The Rationality of the Evolutionary Synthesis and Its Competing Theories

The evolutionary synthesis has stronger empirical coordination force, conceptual coordination force, and background coordination force. It is generally accepted by evolutionary biologists for its stronger comprehensive coordination force. Nowadays, a large amount of new information and new concepts have emerged in evolutionary biology, which goes beyond the traditional framework of evolutionary synthesis and brings many new empirical and conceptual problems to evolutionary synthesis, changing the state of its comprehensive coordination force.

TMT-based quantitative proteomic analysis reveals the spleen regulatory network of dexamethasone-induced immune suppression in chicks

Stress-induced immunosuppression is one of the most widespread problems in the poultry industry. Understanding the molecular regulatory mechanism of immunosuppression induced by stress in the chicken spleen would provide a scientific foundation for the prevention of stress reactions and antistress molecular breeding in poultry. To assess the protein expression profile of spleen tissue in a stress-included immunosuppression model, we performed a TMT-based proteomic analysis of chicken spleen tissue in a Dex-induced immunosuppression model (group C) and a control group (group A). We identified 590 differentially abundant proteins (DAPs) in chicken spleen tissue. These DAPs were significantly enriched in the following functional categories: ECM-receptor interaction, DNA replication, p53 signaling pathway, PI3K-Akt signaling pathway and NF-kappa B signaling pathway. Integrative analysis of the proteome and our previous transcriptome data revealed 62 DAPs showing correlations with the expression of their encoding mRNAs. Complementary proteome- and transcriptome-level analyses revealed a complex molecular network of stress-included immunosuppression. DPP4 and ALDH1A3 were the most significantly upregulated DAPs. GBP and OASL were identified as important nodes in the network related to stress-induced immunosuppression. The candidate genes identified in this study may be useful for the marker-based breeding of new chicken varieties with reduced stress levels. SignificanceThis study provides a large amount of new information about the spleen proteome of the Dex-induced immunosuppression in chicks, as well as the correlation of transcriptome and proteome. Analysis of this resource has enabled us to examine mechanism of protein and transcript diversification, which expands the understanding of the complexity of the mechanism of stress-induced immunosuppression.

A machine-learning history of English caselaw and legal ideas prior to the Industrial Revolution I: generating and interpreting the estimates

AbstractThe history of England's institutions has long informed research on comparative economic development. Yet to date, there exists no quantitative evidence on a core aspect of England's institutional evolution, that embodied in the accumulated decisions of English courts. Focusing on the two centuries before the Industrial Revolution, we generate and analyze the first quantitative estimates of the development of English caselaw and its associated legal ideas. We achieve this in two companion papers. In this, the first of the pair, we build a comprehensive corpus of 52,949 reports of cases heard in England's high courts before 1765. Estimating a 100-topic structural topic model, we name and interpret all topics, each of which reflects a distinctive aspect of English legal thought. We produce time series of the estimated topic prevalences. To interpret the topic timelines, we develop a tractable model of the evolution of legal-cultural ideas and their prominence in case reports. In the companion paper, we will illustrate with multiple applications the usefulness of the large amount of new information generated by our approach.

A Machine-Learning History of English Caselaw and Legal Ideas Prior to the Industrial Revolution I: Generating and Interpreting the Estimates

The history of England’s institutions has long informed research on comparative economic development. Yet to date there exists no quantitative evidence on a core aspect of England’s institutional evolution, that embodied in the accumulated decisions of English courts. Focusing on the two centuries before the Industrial Revolution, we generate and analyze the first quantitative estimates of the development of English caselaw and its associated legal ideas. We achieve this in two companion papers. In this, the first of the pair, we build a comprehensive corpus of 52,949 reports of cases heard in England's high courts before 1765. Estimating a 100-topic structural topic model, we name and interpret all topics, each of which reflects a distinctive aspect of English legal thought. We produce time series of the estimated topic prevalences. To interpret the topic timelines, we develop a tractable model of the evolution of legal-cultural ideas and their prominence in case reports. In the companion paper, we will illustrate with multiple applications the usefulness of the large amount of new information generated by our approach.

ФУНКЦІОНУВАННЯ ЕЛІПТИЧНИХ КОНСТРУКЦІЙ У АНГЛОМОВНИХ НАУКОВО-ТЕХНІЧНИХ ТЕКСТАХ

The article is devoted to the study of one of the most important issues in modern linguistics – the problem of elliptical sentences, namely their definition, classification, different approaches to the study of this phenomenon and functioning in English-language scientific and technical texts. One of the tasks of scientific text is the ability to convey a large amount of new information in a sufficiently limited amount of text. It is this that leads to syntactic compression (the use of an ellipse) in such texts. Syntactic compression, as we have mentioned, is one of the characteristics of the modern scientific style. Authors of scientific texts seek to reduce the amount of text by compression, while increasing its content. Ellipse is a multidimensional phenomenon in language that allows authors to make the communication process more productive by using language savings. The ellipse has an extremely large pragmatic potential in achieving an extralinguistic effect. The use of the ellipse as a means of linguistic economy in scientific and technical texts is especially appropriate because the characteristic features of scientific and technical style are its informativeness (content), logic (strict sequence, clear connection between the main idea and details), accuracy and objectivity. It is an effective way of unloading sentence matter and exempting it from meaningfully redundant or structurally redundant components that carry repetitive information, it is based on the principle of compactification of predicative units. From a stylistic point of view, the desire to save language means leads to the emergence of new constructions that enrich the language, make speech dynamic, expressive. The article considers pragmatic and linguistic features of the ellipse, its structural and functional features. The article traces an attempt to review and structure the main theoretical approaches to the interpretation of the concept of "ellipse", the study of functions that perform elliptical structures in sentence structure and analysis of functional features of elliptical structures in English scientific and technical texts.

Caracterización morfológica de 28 accesiones de cacao silvestre (Theobroma cacao L.) de las cuencas Santiago y Morona - Alto Amazonas

The aim of this research is to promote the development of cocoa areas in Peru which allow expanding the knowledge of the cacao genome. This aim is within the framework of the objectives of the Tropical Crops Institute (ICT). The study was carried out between July 2016 and October 2017. The main task was to evaluate the morphological characteristics of 28 accessions of wild cacao under different field conditions. These 28 accessions were previously selected form the Santiago (SAN) and Morona (MOR)-Alto Amazonas basins, and later stablished in the germplasm bank of ICT – ECC. The research design was non-experimental of the sectional type. The parameters assessed were: quantitative and qualitative descriptors of the plant, leaf, flowers, fruit and seeds. It was found phenotypical variability in the accessions studied, both quantitative and qualitative in vegetative and reproductive organs. And two groups were obtained with the dendrogram. These results indicate that the use of morphological parameters allowed to accumulate a large amount of new information on pre-selected accessions. As well as distinguish phenotypically materials and have more elements to select the most outstanding, which will be included in the next phases of the Genetic Improvement Program of ICT.

Gonadal Hormones and Bone.

In both sexes, estrogen is one of the most essential hormones for maintaining bone integrity. Also, especially in men, androgen has beneficial effects on bone independent of estrogen. However, estrogen replacement therapy for postmenopausal women increases the risk of developing breast cancer and endometrial cancer, and androgen replacement therapy for partial androgen deficiency of the aging male increases the risk of developing prostate cancer. Various mechanisms have been proposed on the effects of gonadal hormones on bone, such as effects through cytokines including IL-6 and effects on the OPG/RANKL ratio. In addition, large amounts of new information deriving from high-throughput gene expression analysis raise the possibility of multiple other effects on bone cells. Both estrogen and androgen exert their effects via the estrogen receptor (ER) or the androgen receptor (AR), which belongs to the nuclear receptor superfamily. Compounds such as selective estrogen receptor modulators (SERMs) and selective androgen receptor modulators (SARMs) also bind ER and AR, respectively. However, SERMs and SARMs alter the ER or AR structure differently from estrogen or androgen, resulting in other downstream gene responses. As a result they can exert favorable effects on bone while suppressing the undesirable actions of estrogen and androgen. Elucidation of ER and AR ligand-specific and tissue-specific gene regulation mechanisms will also provide information on the signal transduction mechanisms of other nuclear receptors and will be valuable for the development of new therapeutic agents.

An overview of meta-analysis for clinicians.

The number of medical studies being published is increasing exponentially, and clinicians must routinely process large amounts of new information. Moreover, the results of individual studies are often insufficient to provide confident answers, as their results are not consistently reproducible. A meta-analysis is a statistical method for combining the results of different studies on the same topic and it may resolve conflicts among studies. Meta-analysis is being used increasingly and plays an important role in medical research. This review introduces the basic concepts, steps, advantages, and caveats of meta-analysis, to help clinicians understand it in clinical practice and research. A major advantage of a meta-analysis is that it produces a precise estimate of the effect size, with considerably increased statistical power, which is important when the power of the primary study is limited because of a small sample size. A meta-analysis may yield conclusive results when individual studies are inconclusive. Furthermore, meta-analyses investigate the source of variation and different effects among subgroups. In summary, a meta-analysis is an objective, quantitative method that provides less biased estimates on a specific topic. Understanding how to conduct a meta-analysis aids clinicians in the process of making clinical decisions.

Predicting crystal growth via a unified kinetic three-dimensional partition model.

Understanding and predicting crystal growth is fundamental to the control of functionality in modern materials. Despite investigations for more than one hundred years, it is only recently that the molecular intricacies of these processes have been revealed by scanning probe microscopy. To organize and understand this large amount of new information, new rules for crystal growth need to be developed and tested. However, because of the complexity and variety of different crystal systems, attempts to understand crystal growth in detail have so far relied on developing models that are usually applicable to only one system. Such models cannot be used to achieve the wide scope of understanding that is required to create a unified model across crystal types and crystal structures. Here we describe a general approach to understanding and, in theory, predicting the growth of a wide range of crystal types, including the incorporation of defect structures, by simultaneous molecular-scale simulation of crystal habit and surface topology using a unified kinetic three-dimensional partition model. This entails dividing the structure into 'natural tiles' or Voronoi polyhedra that are metastable and, consequently, temporally persistent. As such, these units are then suitable for re-construction of the crystal via a Monte Carlo algorithm. We demonstrate our approach by predicting the crystal growth of a diverse set of crystal types, including zeolites, metal-organic frameworks, calcite, urea and l-cystine.

Basic and important points regarding the diagnosis of oral cancers using fluorine-18-labeled fluoro-2-deoxy-d-glucose positron emission tomography–computed tomography: a review

Numerous studies, including our own, have revealed that positron emission tomography–computed tomography (PET/CT) using fluorine-18-labeled fluoro-2-deoxy-d-glucose (18F-FDG) is effective for the diagnosis of oral cancers. Large amounts of new information about primary tumors and metastatic lymph nodes have been acquired, and the use of 18F-FDG PET/CT has been shown to improve diagnostic precision in determining both the pathological characteristics of primary oral cancers and the presence of metastatic lymph nodes. However, substantial variations in 18F-FDG uptake in the oral and maxillofacial regions have been identified, and the differential diagnosis of some oral cancers and metastatic lymph nodes remains difficult for radiologists. Therefore, based on the previous research, the aim of the present study was to review the basic and important points regarding the diagnosis of primary oral cancers and metastatic lymph nodes using 18F-FDG PET/CT.

RELATIONS BETWEEN THE RULING ELITE AND THE MASSES: THE ESSENCE OF THE BASIC APPROACHES AND CONCEPTS

This article discusses the basic concepts of the elites and their relations with the masses. The relations of the elite and masses form a special section of the society, a special relationship. In connection with the emergence of a large amount of new information the individual scientist cannot claim to be exhaustive of the scientific analysis. This analysis allows you to see the major scientific achievements in the sphere of relations of the elite and the masses. Classical concept of elites who are representatives of G. Mosca, V. Pareto and R. Michels, and the modern theory of elites (value theory, the theory of elite democracy and elite concept of multiplicity) were examined. Article contains features typical representatives of mass through which they are easily exposed to the ruling elite. It was concluded that the elite and mass are in a dichotomy, the existence of one is impossible without the existence of the other. No matter what changes have occurred in society, the result is always the same — there is new elite that tried to gain power over the consciousness of the masses. The masses are characterized by representatives of elitism how unstructured, unsystematic education, requiring the control of the ruling elite.

Investigating the genetic polymorphism of sheep milk proteins: a useful tool for dairy production.

Sheep is the second most important dairy species after cow worldwide, and especially in the Mediterranean and Middle East regions. In some countries, the difficult environmental conditions require a peculiar adaptation and, in these contexts, sheep are able to provide higher quality protein than cattle. In the least-developed countries, the amount of dairy sheep and ovine milk production is progressively increasing. In order to improve dairy productions, in particular those with local connotations, it is necessary to obtain in-depth information regarding milk quality and rheological properties. The genetic polymorphisms of milk proteins are often associated with quantitative and qualitative parameters in milk and are potential candidate markers that should be included in breeding strategies similar to those already available for cattle. Due to the current and growing interest in this topic and considering the large amount of new information, the aim of this study was to review the literature on sheep milk protein polymorphisms with a particular emphasis on recent findings in order to give scientists useful support. Moreover, the effects of different protein variants on milk yield and composition are discussed.

The Finnish Disease Heritage Database (FinDis) Update-A Database for the Genes Mutated in the Finnish Disease Heritage Brought to the Next-Generation Sequencing Era

The Finnish Disease Heritage Database (FinDis) (http://findis.org) was originally published in 2004 as a centralized information resource for rare monogenic diseases enriched in the Finnish population. The FinDis database originally contained 405 causative variants for 30 diseases. At the time, the FinDis database was a comprehensive collection of data, but since 1994, a large amount of new information has emerged, making the necessity to update the database evident. We collected information and updated the database to contain genes and causative variants for 35 diseases, including six more genes and more than 1,400 additional disease-causing variants. Information for causative variants for each gene is collected under the LOVD 3.0 platform, enabling easy updating. The FinDis portal provides a centralized resource and user interface to link information on each disease and gene with variant data in the LOVD 3.0 platform. The software written to achieve this has been open-sourced and made available on GitHub (http://github.com/findis-db), allowing biomedical institutions in other countries to present their national data in a similar way, and to both contribute to, and benefit from, standardized variation data. The updated FinDis portal provides a unique resource to assist patient diagnosis, research, and the development of new cures.

Bacterial Sensing, Cell Signaling, and Modulation of the Immune Response During Sepsis

Since the definition of systemic inflammatory response syndrome/sepsis was originally proposed, a large amount of new information has been generated showing a much more complex scenario of inflammatory and counterinflammatory responses during sepsis. Moreover, some fundamental mechanisms of sensing and destroying invading microorganisms have been uncovered, which include the discovery of TLR4 as the lipopolysaccharide (LPS) gene, implications of innate immune cells as drivers of the adaptive response to infection, and the modulation of multiple accessory molecules that stimulate or inhibit monocyte/macrophage and lymphocyte interactions. The complexity of the infection/injury-induced immune response could be better appreciated with the application of genomics and proteomics studies, and LPS was a useful tool in many of these studies. In this review, we discuss aspects of bacterial recognition and induced cellular activation during sepsis. Because of the relevance of endotoxin (LPS) research in the field, we focus on LPS and host interactions as a clue to understand microorganisms sensing and cell signaling, then we discuss how this response is modulated in septic patients.

Evidence for Change: The Case of Subsidios al Campo in Mexico

The Subsidios al Campo campaign used Mexico’s freedom of information laws to obtain official data on the recipients of agricultural subsidies, and then published the data online. Its analysis brought a large amount of new information into the public domain, and managed to shift the debate about agricultural subsidies from a focus on their overall size to a discussion of how equitably they were being distributed, challenging a powerful agricultural industry in the process. The Mexican Ministry of Agriculture reacted by reforming the system to ensure that subsidies were flowing only to those that needed them.

An Effective Method for Ranking of Changed Web Pages in Incremental Crawler

The World Wide Web is a global, large repository of text documents, images, multimedia and much other information, referred to as information resources. A large amount of new information is posted on the Web every day. Web Crawler is a program, which fetches information from the World Wide Web in an automated manner. The crawler keeps visiting pages after the collection reaches its target size, to incrementally update/refresh the local collection. By this incremental update, the crawler refreshes existing pages and replaces less-important pages with new and more-important pages. Incremental web search requires a much smaller amount of data processing of the web. There is a problem in searching new information from the web in incremental web search to evaluate ranking of changed web pages. We developed an effective solution to this problem. In order to evaluate ranking of changed web pages. An Integrated ranking framework combining three metrics: Popularity Ranking, Contentbased Ranking and Evolution Ranking which produce good Ranking for the changed web Pages. Keywords— Popularity Ranking, Content-based Ranking, Evolution Ranking, Integrated Ranking.

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer

Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the management of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines. Relevant articles through December 2008 were reviewed by the task force and categorized by topic and level of evidence according to a modified schema used by the United States Preventative Services Task Force. The revised guidelines for the management of thyroid nodules include recommendations regarding initial evaluation, clinical and ultrasound criteria for fine-needle aspiration biopsy, interpretation of fine-needle aspiration biopsy results, and management of benign thyroid nodules. Recommendations regarding the initial management of thyroid cancer include those relating to optimal surgical management, radioiodine remnant ablation, and suppression therapy using levothyroxine. Recommendations related to long-term management of differentiated thyroid cancer include those related to surveillance for recurrent disease using ultrasound and serum thyroglobulin as well as those related to management of recurrent and metastatic disease. We created evidence-based recommendations in response to our appointment as an independent task force by the American Thyroid Association to assist in the clinical management of patients with thyroid nodules and differentiated thyroid cancer. They represent, in our opinion, contemporary optimal care for patients with these disorders.

The Chalcolithic Period of the Southern Levant: A Synthetic Review

In the southern Levant, the late fifth millennium to mid-fourth millennium BC—traditionally known as the Chalcolithic period—witnessed major cultural transformations in virtually all areas of society, most notably craft production, mortuary and ritual practices, settlement patterns, and iconographic and symbolic expression. A degree of regionalism is evident in material culture, but continuity in ceramic styles, iconographic motifs, and mortuary practices suggests a similar cultural outlook linking these sub-regions. Luxury items found in group mortuary caves provide good evidence for at least some inequality in access to exotic materials. The level of complexity in social organization, however, is still debated. Divergent interpretations of Chalcolithic socio-economic organization suggest that, with the large amount of new information now available, a reevaluation of the debate is due. In this article we synthesize the more recent evidence and weigh interpretations of processes that led to the widespread fundamental changes witnessed during the late fifth to early fourth millennium BC.

Pleistocene evolutionary history of the Clouded Apollo (Parnassius mnemosyne): genetic signatures of climate cycles and a ‘time‐dependent’ mitochondrial substitution rate

Genetic data are currently providing a large amount of new information on past distribution of species and are contributing to a new vision of Pleistocene ice ages. Nonetheless, an increasing number of studies on the 'time dependency' of mutation rates suggest that date assessments for evolutionary events of the Pleistocene might be overestimated. We analysed mitochondrial (mt) DNA (COI) sequence variation in 225 Parnassius mnemosyne individuals sampled across central and eastern Europe in order to assess (i) the existence of genetic signatures of Pleistocene climate shifts; and (ii) the timescale of demographic and evolutionary events. Our analyses reveal a phylogeographical pattern markedly influenced by the Pleistocene/Holocene climate shifts. Eastern Alpine and Balkan populations display comparatively high mtDNA diversity, suggesting multiple glacial refugia. On the other hand, three widely distributed and spatially segregated lineages occupy most of northern and eastern Europe, indicating postglacial recolonization from different refugial areas. We show that a conventional 'phylogenetic' substitution rate cannot account for the present distribution of genetic variation in this species, and we combine phylogeographical pattern and palaeoecological information in order to determine a suitable intraspecific rate through a Bayesian coalescent approach. We argue that our calibrated 'time-dependent' rate (0.096 substitutions/ million years), offers the most convincing time frame for the evolutionary events inferred from sequence data. When scaled by the new rate, estimates of divergence between Balkan and Alpine lineages point to c. 19 000 years before present (last glacial maximum), and parameters of demographic expansion for northern lineages are consistent with postglacial warming (5-11 000 years before present).

The first new application of the Mathematical Theory of Stochastic Processes to lunar and planetary science: Topography-Profile Diagrams of Mars

The Mathematical Statistics Theory (MST) and the Mathematical Theory of Stochastic Processes (MTSP) are different branches of the more general Mathematical Probability Theory (MPT) that can be used to investigate physical processes through mathematics. Each model of a stochastic process, according to MTSP, can provide one or more interpretations in the MST domain. A large body of work on impact crater statistics according to MST exists, showing cumulative crater frequency (N km −2) as a function of age (years) for some particular crater diameter. However, this is only one possible representation in the MST domain of the bombardment of the planetary surface modeled as a stochastic process according to MTSP. The idea that other representations are possible in the MST domain of the same stochastic process from MTSP has been recently presented. The importance of the approach is that each such mathematical-based interpretation can provide a large amount of new information. Coupled with MOLA data, Topography-Profile Diagrams (TPD) are one of the many examples that can provide a large amount of new information regarding the history of Mars. TPD consists of: (1) Topography-Profile Curve (TPC), which is a representation of the planet’s topography, (2) Density-of-Craters Curve (DCC), which represents density of craters, (3) Filtered-DCC (FDCC), which represents DCC filtered by a low-pass filter, included with the purpose of reducing the noise, and (4) Level-of-Substance-Over-Time Curve (LSOTC), which represents interpretation of the influence on the distribution of craters shown by FDCC. TPC uniquely corresponds to the computation of TPD, whereas DCC depends on algorithms for computing the elevation of each crater according to the topography, center coordinates, and radius of impact crater, and FDCC relies on the architecture of the custom designed low-pass filter for filtering DCC. However, all variations of DCC and FDCC, which includes the various impact crater data sets, showed a correlation among the density of craters and elevation over 70–80% of the planet surface. Additionally, if we assume that the ocean primarily caused the noted correlation, LSOTC offers a mathematical approach for estimating topographic change of the ocean’s extent over time. Accordingly, TPD is the first new practical application of MTSP to lunar and planetary sciences, showing correlation of topography to a physical process.