Large Agglomerates Research Articles

On the shear thinning of non-Brownian suspensions: Friction or adhesion?

Shear thinning is fundamental to a broad range of particle suspensions, both in nature and in industrial applications. Yet the mechanisms governing it remain unclear. In particular, the distinct, and often competing, roles of the interparticle, particle-fluid interactions and the particle surface morphology need clarity. By using non-Brownian silica particles with different morphologies, surface functional groups and suspending media, here we reveal two different shear thinning mechanisms, controlled either by frictional or adhesion forces between particles. Smooth glass sphere suspensions in a polar medium (glycerol), where particles interact strongly with the solvent, showed no shear thinning even at high volume fractions (φ ≥ 0.5), while rough silica particles, with similar size distribution, induced shear thinning behaviour at φ values of 0.25 and above. The latter is attributed to the increased frictional contacts in the rough and irregular particles. Considering surface irregularity as elastically deformable asperities enabled us to estimate the critical load above which two neighbouring rough particles experience frictional contacts giving rise to shear thinning. In contrast, in a non-polar solvent (mineral oil), with which the particles do not interact strongly, both glass spheres and the rough silicas showed a pronounced shear thinning response and yield stress behaviour at volume fractions as low as 2% v/v. The rheology of these suspensions is dictated by the adhesion forces between the particles that lead to the formation of large agglomerates, which breakdown under increasing shear. The evolution of the sheared suspensions microstructure was captured using an optical shearing cell, which also enabled us to quantify the particle agglomeration characteristics using an aggregation index. To demonstrate the generality of our approach, we modified the surface chemistry of the glass spheres by introducing hydrophobic groups (e.g. a fluorosilane or palmitic acid) to inhibit inter-particle interactions and improve the dispersion of the otherwise inherently hydrophilic glass spheres in mineral oil; as expected, this suppressed the shear thinning behaviour of the suspensions. The present results clearly elucidate alternative design routes to control suspension rheology, whether to promote or suppress shear thinning, offering new insights for manufacturing and applications of complex particle suspensions.

Tailoring of Electrocatalyst Inks for Performance Enhancement in Proton Exchange Membrane Fuel Cells

One of the main cost and durability controlling components of proton exchange membrane fuel cells (PEMFCs) is the cathode catalyst layer where the oxygen reduction takes place [1]. While the underlying electrochemical mechanisms are currently intensely explored on the fundamental level [2], [3], the ink formulation, which is the most critical step in PEMFC processing is still optimized empirically. As a result, poor formulations with less stable materials show low performance on a lab-scale, hampering their commercialization.Typical inks for catalyst layers consist of Pt nanoparticles supported on carbon-based materials (active material for conductivity, electron transport), and perfluorinated sulfonic acid ionomer (binder for proton transport and mechanical strength) dispersed in suitable solvents. Weakly dispersed inks result in a poor ionomer distribution, form large agglomerates, negatively affect ink rheology due to low colloidal stability, and limit catalyst utilization due to heat and mass transport limitations. This, in turn, significantly reduces the fuel cell performance [4]. For an effective and scalable electrode fabrication, it is necessary to unravel the underlying complex interactions between the multiple nanoparticle species and the solvent mixture forming the catalyst ink. All the techniques that were employed so far to characterize the catalyst inks require modifications to the original ink composition, such as dilution or drying. This makes the assessment of such complex systems challenging and laborious, and sometimes falsifies the results [5], [6].In this study, we experimentally examined the colloidal stability of inks from their settling behavior at their original concentration used in PEMFC manufacturing. Analytical centrifugation (AC) was used to systematically investigate the effects of processing (i.e. energy input during dispersion) on the stability of inks with identical composition. In addition to this, we developed visual maps to elucidate agglomeration behavior of processed inks which is a critical phenomenon for scalable manufacturing of fuel cell electrodes. Finally, this information was linked to the catalyst particle morphology and structure, handling properties and the final electrode performance to close the design chain from process to structure to property. In combination with electron microscopy and rheological investigations, tailored catalyst inks were developed for economical and durable formation of fuel cell cathodes.

Encapsulation and Release Control of Fish Pathogen Utilizing Cross-Linked Alginate Networks and Clay Nanoparticles for Use with a Potential Oral Vaccination

Streptococcus parauberis is utilized as an oral vaccine by first inactivating the cells with formalin to produce formalin- killed cells (FKC) and then encapsulating them with polymer beads consisting of a cross-linked alginate-Ca2+ network. The encapsulation efficiency and media-dependent release are controlled by pre-treating the FKC with two types of clay nanoparticles: kaolinite (KA) and layered double hydroxide (LDH). The addition of LDH induced large agglomerates of FKC, and the KA enhanced the dispersion of FKC. The differences in the dispersibility of the FKC upon the use of clay nanoparticles was determined to strongly affect the encapsulation efficiency and release properties. The FKC + LDH mixture exhibited a slightly reduced encapsulation efficiency compared to the FKC alone. However, FKC + KA exhibited a dramatically improved encapsulation efficiency. In terms of the media-dependent release, the alginate beads were found to be fairly stable under gastric conditions and in deionized water with or without clay nanoparticles, preserving most of the encapsulated FKC. The intestine was the final target organ for FKC vaccination, and release at the site varied according to the use of clay nanoparticles. Both clays seemed to enhance the release of FKC, the cumulative amount being 3.6 times and 1.3 times larger for LDH and KA, respectively, than was shown with only FKC encapsulated beads.

Magnetic nanoparticles in toner material

Printers and copiers necessitate toner material which is device and therefore company dependent. These materials being part of everyday life and cheap exhibit different toner particles that are microscaled objects consisting of nanoparticles. The differences are related to the chemical composition, the shape and the size.The first aim was to find toner material which contains magnetic substances. The subsequent goal of this investigation was a detailed examination of the material composition, the shape, the size, as well as a possible crystallinity of the micro- and nanoscaled particles from three different toner materials (distributed by Samsung, Hewlett–Packard, and Kyocera) all being commercially available. The background is aimed at the question whether these particles can be taken for magnetically related scientific investigations instead of carrying out complicated, long-lasting and expensive preparation procedures.It could be demonstrated that cheap toner material can be used to obtain magnetic iron oxide nanoparticles of about 10 to 20 nm with a narrow size distribution using the investigated toner materials. With benzene, toluene, and n-hexane as organic solvent these nanoparticles are agglomerates of particles with a diameter being significantly below the micrometer size. Without dispersing one obtains large agglomerates of about 10μm.Using the toner material of Hewlett–Packard and Kyocera the metallic nanoparticles themselves exclusively consist of crystalline magnetite. Taking that of Samsung two configurations are present with about two thirds of magnetite and one third of maghemite.

Kalsit Takviyeli Poli (Laktik Asit) Kompozit Malzemelerinin Hazırlanması ve Karakterizasyonu

In this work, calcite (KS) mineral was compounded with poly (lactic acid) (PLA) at the concentrations of 5, 10, 15 and 20 wt% using extrusion process. Test samples of PLA and composites were prepared by injection molding. Characterization of composites were done based on mechanical tests including tensile, hardness and impact tests, flow behavior by melt flow rate test (MFR) and morphological studies by scanning electron microscopy (SEM) method.[A1] Mechanical test results showed that the highest improvements in tensile strength and tensile modulus values were obtained for 10 wt% of KS filled composite. Further addition of KS caused remarkable decrease in tensile strength. Impact strength of PLA reduced by KS additions. The highest impact energy value was found in PLA-15 KS sample among composites. Hardness of neat PLA increased after KS inclusions. KS loaded PLA gave slightly higher MFR values compared to neat PLA. SEM micro-images of composites implied that KS particles dispersed homogeneously in PLA matrix at their lower loading ratio. Large agglomerates and poor dispersion were obtained for higher concentrations of KS since they favor particle-particle interactions. According to these results, concentrations of 10wt% and 15wt% were determined as suitable for calcite containing PLA composites. [A1]Bu cümleyi yeniden yazabilir misiniz? Biraz karışık olmuş. Konuyu bilmeyen biri okuduğunda sertlik, çekme ve darbe testlerinin mekanik olduğunu bilmeyebilir. Bunu ayrı cümlelerde yazarsanız daha iyi olur.

The Effect of a Small Copper Addition on the Electrical Conductivity of Aluminum

Aluminum powder blended with 10, 20, and 30 wt% of copper powder is compacted at 400 °C by four reciprocal extrusion passes. Simultaneous compaction and strengthening result in more than double increase in mechanical strength characteristics for 20 and 30 wt% of copper and a significant increase in electrical conductivity for 30 wt% of copper. This phenomenon is investigated here by the expansion of the “effective media” model for a random binary mixture so that it includes the presence of intermetallic phases and considers the distribution of large copper agglomerates.

Ultrasonic-assisted de-agglomeration and power draw characterization of silica nanoparticles.

Breakage of nanoparticle cluster require high-intensity devices for stable and uniform distribution of aggregates. The ultra-sonication process is a high energy-intensive technique that produces cavitation effect to break the aggregates. In the present study, ultra-sonication is used for the de-agglomeration of fumed silica nanoparticles in low to high viscosity liquids. Water- and glycerol-based dispersion has been investigated at different solid loadings (up to 10wt% for water-based dispersion and 5wt% in glycerol-based dispersion) and viscosity of continuous phase (1-100mPa.s). Breakup mechanism and kinetics have been studied at optimized operating conditions and no significant effect is found at different solid loadings on breakup mechanism. Particle size measurements are reported and found that volume of fine generation increased with an increase in sonication time. Further, it is observed that the stability of dispersion in the liquid is very high even at high concentration of solid used. Larger agglomerates are found at high viscosity of continuous phase and a lag is also observed for 100mPa.s glycerol solution even at low solid loading (1wt%). From, rheological characterizations it is found that the behavior of dispersed solution changed with time, temperature and solid loading. Erosion is found to be the breakup mechanism and further, validated with scattering light characterization. Furthermore, power draw increased with an increase in the viscosity of continuous phase, however, no significant effect of solid loading is observed. It is also observed that process is more energy-efficient at higher solid loading as the volume of fine produced is more as compared to low solid loading. Therefore, it can be concluded that the stable and uniform dispersion of nanoparticles can be achieved using an ultra-sonication device at high solid loading in viscous liquids.

Highly Correlated Size and Composition of Pt/Au Alloy Nanoparticles via Magnetron Sputtering onto Liquid

Pt/Au alloy nanoparticles (NPs) in a wide composition range have been synthesized by room-temperature simultaneous sputter deposition from two independent magnetron sources onto liquid PEG (MW = 600). The prepared NPs were alloyed with the face-centered cubic (fcc) structure. In addition, the particle sizes, composition, and shape are strongly correlated but can be tailored by an appropriate variation of the sputtering parameters. No individual particle but large agglomerates with partial alloy structure formed at Pt content of less than 16 atom %. Highly dispersed NPs with no agglomeration were observed in PEG when the quantity of Pt is more than 26 atom %. On the other hand, a small amount of Pt could terminate the agglomeration of Au when sputtering on the grids for transmission electron microscope observation. Our experiment and computer simulation carried out by two different methods indicate that the composition-dependent particle size of Pt/Au can be explained by the atomic concentration, formation energy of the cluster, and interaction between different metal atoms and the PEG molecule.

A comparative study of the mechanical integrity of natural hydroxyapatite scaffolds prepared from two biogenic sources using a low compaction pressure method

With a view to enhancing laboratory and application-based pedagogical approaches in bioengineering, a comparison of the physical, chemical and mechanical properties of natural hydroxyapatite produced from non-separated animal bones (NB) and catfish bones (CB) obtained by thermal treatment and a low compaction pressure method has been reported in this study. The structure, morphology and surface chemistry of the processed biomaterials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and infrared spectroscopy, respectively. Uniaxial compaction using a pressure of 1 MPa was used on circular shaped hydroxyapatite scaffolds to measure the mechanical properties of the produced scaffolds. From XRD analysis, both samples showed prominent reflections of the hydroxyapatite phase, suggesting high crystallinity and phase stability. The morphology of the powders showed irregular shapes with large agglomerates for non-separated animal bones-derived hydroxyapatite as compared to more open pores in the catfish bones-derived hydroxyapatite. Hydroxyapatite produced from catfish bones revealed a microstructure with open pores which is useful in terms of cell adhesion. The hydroxyapatite products revealed Ca/P ratios of 1.58 and 1.63 for catfish bones (CB) and non-separated animal bones-derived hydroxyapatite, respectively. Improvements in the fracture toughness were observed for CB in comparison with NB. Calculated fracture toughness values were 5.72 MPa.m1/2 and 2.35 MPa.m1/2 for catfish bones and non-separated animal bones-derived scaffold respectively. These results are useful in terms of the production and biomedical applications of natural hydroxyapatite.

Investigation of spitting behaviour of NiCoCrAlY type materials during electron beam evaporation

ABSTRACTSpitting behaviour of four casted and powder metallurgy ingots used in the fabrication of NiCoCrAlY-type environmental protective coatings by electron beam physical vapour deposition was investigated and correlated with ingot microstructures and compositions. Spits found in the coatings mainly consisted of the Ni5Y phase precipitated in the β-NiAl matrix while their typical size exceeded 50 µm. Spitting was less pronounced for ingots having a higher Cr content, larger size of γ-Ni(Co, Cr) precipitates formed within β-NiAl grains and narrower transitional zone formed at the interface between molten and unmolten ingot regions and consisting of coarsened β grains. Large (above 100 µm) agglomerates of the Ni5Y phase detected below the zone were identified as the main spit precursors.

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

BackgroundThe terms agglomerates and aggregates are frequently used in the regulatory definition(s) of nanomaterials (NMs) and hence attract attention in view of their potential influence on health effects. However, the influence of nanoparticle (NP) agglomeration and aggregation on toxicity is poorly understood although it is strongly believed that smaller the size of the NPs greater the toxicity. A toxicologically relevant definition of NMs is therefore not yet available, which affects not only the risk assessment process but also hinders the regulation of nano-products. In this study, we assessed the influence of NP agglomeration on their toxicity/biological responses in vitro and in vivo.ResultsWe tested two TiO2 NPs with different primary sizes (17 and 117 nm) and prepared ad-hoc suspensions composed of small or large agglomerates with similar dispersion medium composition. For in vitro testing, human bronchial epithelial (HBE), colon epithelial (Caco2) and monocytic (THP-1) cell lines were exposed to these suspensions for 24 h and endpoints such as cytotoxicity, total glutathione, epithelial barrier integrity, inflammatory mediators and DNA damage were measured. Large agglomerates of 17 nm TiO2 induced stronger responses than small agglomerates for glutathione depletion, IL-8 and IL-1β increase, and DNA damage in THP-1, while no effect of agglomeration was observed with 117 nm TiO2.In vivo, C57BL/6JRj mice were exposed via oropharyngeal aspiration or oral gavage to TiO2 suspensions and, after 3 days, biological parameters including cytotoxicity, inflammatory cell recruitment, DNA damage and biopersistence were measured. Mainly, we observed that large agglomerates of 117 nm TiO2 induced higher pulmonary responses in aspirated mice and blood DNA damage in gavaged mice compared to small agglomerates.ConclusionAgglomeration of TiO2 NPs influences their toxicity/biological responses and, large agglomerates do not appear less active than small agglomerates. This study provides a deeper insight on the toxicological relevance of NP agglomerates and contributes to the establishment of a toxicologically relevant definition for NMs.

An investigation on the influence of nano silica morphology on the characteristics of cement composites

Nanosilica is produced with various methods and each product has particular applications in the industry. The differences between the nanosilicas are mainly attributed to their morphology. For instance, some types of nanosilicas such as nanosilica gels have large agglomerates, while some others like nanosilica sols may be produced in the monodispersed form. The main objective of this article is investigating the differences between the influences of agglomeration state of nanosilica, as an aspect of morphology, on the characteristics of cement composites. Among the nanosilica types, nanosilica gel has been scarcely investigated in the cement based materials researches. Thus, a simple method for production of nanosilica gel is presented. Then, the characteristics of cement mixtures containing this material have been compared with those incorporating a monodispersed nanosilica sol and silica fume. The properties investigated in this study include shrinkage measurements, compressive strength, water sorptivity, cement hydration, flow ability, setting times and rapid chloride migration coefficient. The results indicate that, despite the agglomeration state, at early ages, nanosilica gel outperformed the silica sol and silica fume in improving the characteristics such as compressive strength. It confirms that the monodispersed form of nanosilica sol could not provide higher levels of nucleation centers in the mixture; in other words, coagulation of nano particles is inevitable in the environment of cement-based materials. Likewise, at long term, nanosilica gel incorporated concretes had improved durability in terms of chloride penetration and water sorptivity compared to those with monodispersed nanosilica sol.

Synthesis and Characterization of SmBa2Cu3Oy Powder Prepared by Solid-State Reaction

In this work, the SmBa2Cu3Oy (Sm-123) powder was successfully prepared by solid-state reaction method under a normal air atmosphere using a stoichiometric ratio (i.e., Sm:Ba:Cu = 1:2:3) of high-purity Sm2O3, BaCO3 and CuO starting powders. Thermal properties of the as-calcined powder were studied by DSC/TGA technique and the results showed a formation of Sm-123 phase at 900 °C. The as-calcined powder was prepared by heating the starting precursors at 900 °C for 6–30 h. Phase identification was determined using an X-ray diffractometer (XRD). The quantitative phase analysis was analyzed by fitting the XRD pattern using the GSAS-II program. The result of XRD showed that the SmBa2 Cu3Oy (Sm-123) was identified as the main crystalline phase. The morphology was observed by scanning electron microscopy (SEM) with chemical composition identification from EDS mode. The surface of Sm-123 powder exhibited large agglomerates with a size range of ∼4.44–6.75 m. The Raman spectra showed a vibrational Raman-active phonon mode lying at around ∼502–508 cm–1. The peaks originated from the apical oxygen O(4) (i.e., O(4)-Ag mode) along the c-axis could be correlated with the oxygen deficiency in the CuO2 planes of orthorhombic SmBa2Cu3Oy. The calculated oxygen content from these peaks tended to decrease with increasing calcination time. All of these frequencies confirmed the presence of phonon and bonding typical for the 123-type structure.

A Circular Economy Virtuous Example—Use of a Stabilized Waste Material Instead of Calcite to Produce Sustainable Composites

This work reports and analyzes the mechanical properties of some composites obtained using stabilized waste with epoxy resins E-227. For comparison, correspondent composite samples were realized using calcite as a filler. The recovered stabilized waste was obtained by means of a new method to stabilize municipal solid waste incineration (MSWI) fly ash (FA), based on the use of bottom ash (BA). The aim of this paper is to show that the stabilization process, which can be considered a zero—waste treatment, produces inert materials, that can be reused as a filler. The production of new filler was made on a pilot plant, designed to verify the transferability of the proposed stabilization technology. Mechanical analysis revealed that flexural modulus raises by increasing the filler content around 30% wt, independently of filler type, stabilized sample or calcium carbonate. Mechanical properties are lower in the samples with the high amount of filler due to the crowding effect. The morphology of composite materials showed a non-homogeneous dispersion of particles in stabilized sample filler, characterized by large particle agglomerates. Finally, according to the ESCAPE simplified method, the obtained composites result more sustainable in comparison with the corresponding ones produced by using natural resources (like calcite). These findings open new possibilities for the reuse of the stabilized material, in frame of circular economy principles, with environmental and economic advantages.

Continuous Spherical Crystallization of Lysozyme in an Oscillatory Baffled Crystallizer Using Emulsion Solvent Diffusion in Droplets

Continuous protein crystallization is a cost-effective alternative to traditional chromatographic purification techniques. However, proteins characteristically have slow growth rates, requiring long crystallization times to generate particles large enough for efficient isolation. In this work, spherical crystallization using an emulsion solvent diffusion (ESD) based methodology is proposed to produce large lysozyme agglomerates in an oscillatory baffled crystallizer (OBC). Process sensitivity analysis was performed to investigate the effect of the process parameters on the product’s crystal size distribution at two different scales. The concentration of ethanol in the bulk phase was found to have a significant effect on the crystallization kinetics, as its diffusivity drives supersaturation at the droplet interface. Although controlling supersaturation is important in determining product quality, maintaining droplet suspension near the injection site is critical for process longevity, as fouling is most l...

Facile preparation of NaV 3 O 8 /polytriphenylamine composites as cathode materials towards high‐performance sodium storage

NaV3O8/polytriphenylamine composites were synthesized by an in situ oxypolymerization way for the first time. Among them, the NaV3O8/20 wt.% polytriphenylamine composite shows better cycling and rate performance. Its discharge capacity retains at 118.9 mAh g−1 after 300 cycles at 120 mA g−1. It also obtains a reversible capacity of 101.7 mAh g−1 at 300 mA g−1 after 100 cycles. These enhanced results arise from the excellent morphology, that is, smaller particles of clear edges and uniform distribution suppress the expansion and deformation of the crystal structure, and avoid large agglomerate particles gathering during the electrochemical reaction. In addition, tight polytriphenylamine (PTPAn) coating also improves the conductivity of NaV3O8 cathode and suppresses the dissolution of NaV3O8 in electrolyte.

Poly(methyl methacrylate) Films with High Concentrations of Silicon Quantum Dots for Visibly Transparent Luminescent Solar Concentrators.

Silicon quantum dots (Si QDs) are attractive, nontoxic luminophores for luminescent solar concentrators (LSCs). Here, we produced Si QD/poly(methyl methacrylate) (PMMA) films on glass by doctor-blading polymer solutions and achieved films with low light scattering at an order of magnitude higher Si QD weight fraction than has been achieved previously in the bulk. We suggest that the fast solidification rate of films as compared to slow bulk polymerization is an enabling factor in avoiding large agglomerates within the nanocomposites. Scanning electron microscopy confirmed that ∼100 nm or larger QD agglomerates exist in light-scattering films, and photoluminescence intensity measurements show that light scattering, if present, significantly reduces waveguiding efficiencies for LSCs. Nonscattering films fabricated in this work exhibit high ultraviolet absorption (>80%) paired with high visible transmission (>87%) and minimal visible haze (∼1%), making them well suited for semitransparent coatings for LSCs realized as solar harvesting windows.

Effect of Al content and particle size on the combustion of HMX-CMDB propellant

In solid propellants, aluminum plays a key role in energy performance enhancement, but it also induces combustion problems such as low combustion efficiency and agglomeration. Herein, we study the effects of Al on the combustion properties of low-signal composite-modified double-base (CMDB) propellants. Experiments were conducted to determine the heat of explosion, the burning rates, and the combustion wave structures. The flame structure, the burning surface phenomenon and the morphology of the extinguished surface layer were observed. In addition, distribution of Al particles was calculated. It was found that using small Al particles or lowering the Al content will reduce the burning rate. This result was mainly cause by the “thermal sink” effect of Al. The Al agglomeration and ignition behaviors in the dark zone and the flame zone were observed at 1 and 3 MPa. It was found that propellants containing more than 10 wt.% Al or using Al particles smaller than 5 µm tended to generate large Al agglomerates. The extinguished burning surface presented “metal skeleton” structure under low pressures. The Al particles smaller than the HMX would be locally concentrated, so that it was easier for them to form large agglomerates.

Pomegranate-Structured ZnMn2O4 Microspheres for Long Cycle Life Lithium Ion Anode and Elucidation of Its Conversion Mechanism

Pomegranate-structured ZnMn2O4 microspheres with high capacity and a long cycle life for lithium ion anode are prepared via a carbonate coprecipitation method followed by a thermal annealing process. The microspheres are consisted of a nano-thick dense shell and a large agglomerate porous core, thus the term “pomegranate-structured.” The ZnMn2O4 microspheres deliver a high capacity of 810 mAh g−1 at a current density of 100 mA g−1, and significant cycling stability with little capacity loss over 560 cycles at 500 mA g−1 and 1600 cycles at 1000 mA g−1. Scanning electron microscopy reveals the well preservation of the microspherical architecture for the long-cycled electrode material, which could account for the long cycle life and excellent cycling stability of the ZnMn2O4 microspheres. Transmission electron microscopy demonstrates ZnMn2O4 nanoscrytallites are formed in the cycled electrode after charging to 3 V, indicating the further reaction of ZnO and MnO during the charging process, which is first found for the ZnMn2O4 electrode. Moreover, the CV characterizations of the ZnMn2O4 anode with discharge/charge cycling reveals a new oxidation peak occurs at 2.3 V after dozens of discharge/charge cycles, which can be assigned to the oxidation conversion of Mn2+ → Mn3+. Our study investigates and clarifies the conversion mechanism of the ZnMn2O4 anode.

Investigation of short-term stability of parenteral nutrition nanoemulsions prepared under laboratory conditions

Background/Aim. The application of nanoemulsions (NE) in parenteral nutrition represents a very important advancement that marked the medicine and pharmacy of the twentieth century. Over the years, the technology of the production of NE and total parenteral nutrition (TPN) nanoemulsions or admixtures has undergone constant improvement. Representing the continuation of the previous research, this paper deals with nanoemulsions in a concentration of 20% that were prepared under laboratory conditions. The main emphasis was put on the possibility of detecting the potential presence of large droplets or agglomerates of droplets that could cause fatal effects. In addition, the quality assessment of the TPN admixture containing these nanoemulsions was performed. These results were compared with the results obtained from the TPN admixture prepared from the industrial emulsion (Lipofundin MCT/LCT 20%?). Methods. During the 30-day period of monitoring nanoemulsion physical-chemical characteristics, the volume diameters that define the width of the lipid droplet size distribution were determined using the laser diffraction method. In addition, TPN physical and chemical characteristics were monitored for 72 hours and included: measurements of the mean droplet diameter, the volume diameter, distribution of the droplet size, ie. polydispersity index (PDI), ?-potential, and pH values. Results. Obtained results were in accordance with the literature data related to the quality of parenteral nanoemulsions (values of volume diameters ranged between 50 and 490 nm). TPN admixtures remained stable during the testing period, even in cases when TPN admixtures containing either a newly formed or an industrial nanoemulsion were tested. Conclusion. Characteristics of investigated nanoemulsions do not significantly alter under the ambient temperature storage. If the preparation principles and the component mixing order are followed, TPN admixture possessing satisfactory physical and chemical quality and stability can be obtained.