In recent years, traditional medicine has been used to treat various diseases such as anemia. One of these plants is Saussurea lappa .The objective of the study is to investigate the impact of an aqueous extract of Saussurea lappa root (AESL) on Tamoxifen-induced anemia in female albino rats. A total of twenty-four rats (180-190 g) were separated into 4 groups (n= 6 for each group).Group (1), normal control was received only normal saline solution. Group (2), administered orally AESL (200 mg/kg body weight. Group (3), received orally tamoxifen (TAM, 40 mg/kg body weight). Group (4), givenTAM concurrently with AESL.TAM was administered concurrently with AESL for 28 successive days.The results showed that TAM intoxication had led to significant depletion in, red blood cells count (RBCs), hemoglobin (Hb),mean corpuscularhemoglobin (MCH), hematocrit (HCT), white blood cells count (WBCs) and platelets in TAM intoxicated ratsversus control counterparts.No significant changes in mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were observed in TAM intoxicated rats versus control ones .Oral intake of AESL concurrently with TAM markedly ameliorated the depletion in WBC, RBC, Hb, MCH, HCT and platelets when compared with TAM intoxicated rats.This investigation revealed that oral intake of AESL in parallel with TAM can protect against hematotoxicityrelated to TAMThis result may candidate the useof AESL in the treatment of blood cell disorder. Keyword: Anemia, Saussurea lappa,Tamoxifen,Hb