This current study provides a comprehensive examination of a novel method for studying the dynamics of a fractionalized Maxwell flow near an inclined plate, considering non-uniform mass transfer through a permeable media. Through the use of partial differential equations, incorporating heat and mass movement effects, the study employs a combination of generalized Fick’s and Fourier’s law with the Caputo operator. Transforming the fractionalized model into dimensionless form using appropriate dimensionless values, semi-analytical solutions for the non-dimensional transmitted fractional model are obtained via the Laplace transformation method. Through graphical analysis, the precise contributions of key parameters such as heat generation, radiation, and chemical reactions are elucidated, including their impacts on the calculated heat generation parameter (Qo), radiation parameter (Nr), and others. The study’s significance lies in its implications for the design of efficient heat exchangers, fluid flow systems, and cooling components in complex engineering systems, including nuclear reactors and power generation plants. Furthermore, the fractional derivative approach offers a more accurate representation of the viscoelastic behavior of materials like polymers, crucial for optimizing fabrication processes such as extrusion and molding. The insights gained from this study extend to the realm of miniaturized fluidic devices, including bio-analysis tools, lab-on-a-chip technology, and microfluidic drug delivery systems, where improved performance and control need a grasp of Maxwell fluid dynamics. The physical outcome of this research lays the groundwork for future investigations that will maximize heat transfer efficiency in real-world systems and give insightful information on the behavior of complicated fluids. We compute and display the skin friction, mass and heat transfer rate in tabular form.