replacement of the myometrium by adenomyosis. Th e fallopian tubes appeared macroscopically normal. Haematoxylin and eosin (H & E) staining showed classical features of adenomyosis with endometrial glands and myometrial hyperplasia throughout the uterus. Routine histology of the fallopian tubes was normal. Immunohistochemical staining of the uterus of full thickness samples from the endometrium to the serosa with anti-S100 confi rmed widespread absence of nerves at the endometrial – myometrial interface, and, throughout the adenomyosis. Th e isthmus of both fallopian tubes showed complete loss of nerves in the inner layer of longitudinal smooth muscle (Figure 1). Case report 2 A 48-year-old, Chinese woman presented with a 5-year history of painful, irregular periods. Ten years previously, she had a left ovarian cystectomy, myomectomy and sterilisation. Five years previously, she underwent hysteroscopy and curettage for simple endometrial hyperplasia. She had two previous vaginal deliveries and a mid-trimester miscarriage requiring surgical evacuation of the uterus. CA125 was normal; ultrasound examination demonstrated adenomyosis and a small right, ovarian cyst. She underwent laparoscopic subtotal hysterectomy with bilateral salpingectomy and right ovarian cystectomy. Th e postoperative course was uncomplicated. Histology confi rmed a uterus weighing 160 g and extensive adenomyosis. Th ere was evidence of collateral sprouting of nerve bundles and abnormal nerves in the subserosal and subendometrial layers of the uterus. Th e fallopian tubes showed loss of nerves in the inner longitudinal muscle layer (Figure 1). Th e Ethics Committee of the Women ’ s Hospital, University of Zhejiang gave permission for these studies. Discussion Th ese reports confi rm previous observations of absence of nerves at the endometrial – myometrial interface and throughout the proliferating columns of adenomyosis in diff erent clinical presenta