INTRODUCTION AND OBJECTIVES: Compared to open prostatectomy, both pure laparoscopic radical prostatectomy (LRP) and robot assisted laparoscopic prostatectomy (RALP) remarkably reduce the postoperation pain. However, differences between LRP and RALP techniques in terms of postoperative pain have not been yet explored. METHODS: A total of 100 patients requiring prostatectomy were randomized in 2 groups. One group was treated with LRP technique (LRPg), while the other group was treated with RALP (RALPg). In both groups intraoperative anesthesia and postoperative analgesia were managed according to the same protocols. The degrees of postoperative pain were evaluated on each patient by the Visual Analogue Scale diffused (VAS D), incident (the pain on light compression of surgical wound) (VAS I) and “referred” (the shoulder-pain) (VAS R) pain scores. The 3 VAS pain scores, the consumption of analgesic opiods (buprenorphine), and the amount of rescue drugs (acetaminophen) at 1, 3, 6 and 24 h after surgery in the 2 groups were compared respectively. RESULTS: Althought both group have low VAS D and VAS I, RALPg has lower VAS than LRPg. Change in post operative pain VAS I (Fig 1) and VAS D (Fig 2). VAS 0 no pain, VAS 10 maximum pain. Measurements were recorded at 1, 3, 6, 24 h after operation. Vertical bars denote 0.95 confidence intervals. Otherwise VAS R in all the evaluation, at 1, 3, 6 and 24 h after surgery, were not statistically significative. Compared to the LRPg, the RALPg required less analgesic opioids (345 53 mg vs. 451 103 mg, p 0.001). The cases requiring rescue drugs were lower in RALP group than in LRPg both at 24 h (24.32% versus 46,87%, p 0.05), and at 48 h after surgery (12.12% versus 18.51%, p 0.05). CONCLUSIONS: Our study suggests that RALP causes less postoperative pain than LRP with lower required of analgesic drugs in post operative period. Further studies are required to confirm and explain these data. Source of Funding: None