Objective: To investigate the feasibility and safety of laparoscopic jejunostomy with ENDO STITCH™ automatic suturing device for patients with esophageal cancer. Methods: From November 2010 to January 2011, four patients with esophageal cancer underwent laparoscopic jejunostomy with ENDO STITCH™ automatic suturing device. Three patients presented with metastatic esophageal cancer and dysphagia. One patient underwent total laparoscopic and thoracoscopic esophagectomy for early esophageal cancer, with laparoscopic jejunostomy for post-operative nutrition support. Results: The laparoscopic jejunostomy was successfully performed with ENDO STITCH™ automatic suturing device in 4 patients. No major complications were observed during and after operation. ALL patients resumed anal exsufflation and could be out of bed on the first day after operation. The enteral nutrition was administered 24 h after operation. During follow-up, patients with metastatic esophageal cancer all used jejunal feeding tube to receive enteral nutrition during chemotherapy, and the weight was maintained. Conclusion: Laparoscopic jejunostomy with ENDO STITCH™ automatic suturing device is a safe and feasible technique. It is potentially accepted in patients with advanced esophageal cancer for nutrition support. DOI: 10.3781/j.issn.1000-7431.2011.09.015