Reduced water quality due to the eutrophication process causes large economic losses worldwide. Multi-source remotely-sensed water quality monitoring can help provide effective water resource management. The research evaluates the retrieval of the water quality parameters: chlorophyll-a (Chl-a), total suspended matter (TSM), and chromophoric dissolved organic matter (CDOM), over optically different water types. Cross-sensor performance analysis of three satellite data sources: Sentinel-3 Ocean Land Color Imager (OLCI), Sentinel-2A Multi-Spectral Instrument (MSI), and Landsat-8 Operational Land Imager (OLI), acquired during a 45 min overpass on the Nile Delta coast on 22 March 2020 was performed. Atmospheric correction using the case 2 Regional Coast Color (C2RCC) was applied using local water temperature and salinity averages. Owing to the lack of ground-truth measurements in the coastal water, results were inter-compared with standard simultaneous color products of the Copernicus Marine Environment Monitoring Service (CMEMS), OLCI water full resolution (WFR), and the MODIS Aqua, in order to highlight the sensor data relative performance in the Nile Delta’s coastal and inland waters. Validation of estimates was carried out for the only cloud-free MSI data available in the 18–20 September 2020 period for the Burullus Lake nearly contemporaneous with in situ measurements in the 22–25 September 2020. Inter-comparison of the retrieved parameters showed good congruence and correlation among all data in the coastal water, while this comparison returned low positive or negative correlation in the inland lake waters. In the coastal water, all investigated sensors and reference data showed Chl-a content average of 3.14 mg m−3 with a range level of 0.39–4.81 mg m−3. TSM averaged 7.66 g m−3 in the range of 6.32–10.18 g m−3. CDOM clarified mean of 0.18 m−1 in the range level of 0.13–0.30 m−1. Analysis of the Mean Absolute Error (MAE) and the Root Mean Squared Error (RMSE) clarified that the MSI sensor was ranked first achieving the smallest MAE and RMSE for the Chl-a contents, while the EFR proved superior for TSM and CDOM estimates. Validation of results in Burullus Lake indicated a clear underestimation on average of 35.35% for the Chl-a induced by the land adjacency effect, shallow bottom depths, and the optical dominance of the TSM and the CDOM absorption intermixed in turbid water loaded with abundant green algae species and counts. The underestimation error increased at larger estimates of the algal composition/abundance (total counts, Chlorophyacea, Euglenophycaea, and Bacillariophycaea) and the biological contents (carbohydrates, lipids, and proteins), arranged in decreasing order. The largest normalized RMSE estimates marked the downstream areas where the inflow of polluted water persistently brings nutrient loads of nitrogen and phosphorous compounds as well as substantial amounts of detrital particles and sediments discharged from the agricultural and industrial drains and the land use changes related to agricultural practices, resulting in the increase of water turbidity giving rise to inaccurate Chl-a estimates.
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