Introduction. The development of land relations in Ukraine has led to changes in land management. The redistribution of land as the main national wealth of our state have exacerbated the economic and environmental problems of agricultural land use. Ukrainian agricultural producers must to ensure effective competition, production of environmentally friendly products, focus on the world market and determine the need to improve environmental and economic management of land resources. The purpose of article. The purpose of the study is the theoretical and methodological justification of ecological and economic management of land resources in the structure of zonal approaches to the formation and development of agricultural enterprises and the development of practical recommendations for improving the efficiency of land use by agricultural producers. Methods. The research used scientific and methodological foundations of natural-agricultural zoning of the territory of Ukraine, the allocation of taxonomic units of zoning and their main characteristics. Results of work. The scientific novelty of the obtained results concerns the improvement of ecological and economic management of land resources of agricultural enterprises in the conditions of zoning, taking into account the potential of agricultural areas. Economic and ecological management of land resources of agricultural enterprises should be considered as an activity in agricultural production aimed at providing the population with food and other sectors of the national economy with raw materials at the optimal level of investment in resources and their maximum return in compliance with environmental goals and programs. Agricultural zoning as a branch in the agricultural sector of the economy is highlighted, its component structure is revealed. The agrarian zone includes homogeneous land massifs with the corresponding production potential and level of ecological and anthropogenic loading and allows public administration bodies to be defined with potential possibilities of production activity of the agrarian enterprises. Within the Sumy region, four agricultural zones were identified, and in the Kharkiv region, three. Depending on the affiliation of land use to the agrarian zone, the agricultural enterprise receives information on zoning crops most suitable for cultivation on its territory, types of crop rotations, technological measures for land use and protection, restrictions on growing certain crops. Economic indicators of enterprise development, such as specialization, concentration and integration of production, with skillful application will help increase the efficiency of land use. Socio-economic classification features of agricultural zoning will determine the level of labor efficiency and the integration of labor. To economically justify the coefficients of the optimal ratio of land using a zonal approach and to take into account the area of eroded, unproductive and contaminated land located in the administrative-territorial units, the optimal ratio of land was determined (arable land: natural forage lands: forests and other forests): in the Sumy region: 1.00: 0.43: 0.39; in the Kharkiv region: 1.00: 0.23: 0.25. When introducing research into production, we take into account that ecological zoning restricts the cultivation of certain crops, taking into account local characteristics.