In order to explore the effect of combining straw and desulphurized gypsum on improving coastal saline-alkali soil, taking the alkaline saline soil in the Yellow River Delta as the research object, six treatments including the control (CK), desulphurized gypsum (DG), medium straw amount (MS), desulphurized gypsum+low straw amount (DGLS), desulphurized gypsum+medium straw amount (DGMS), and desulphurized gypsum+high straw amount (DGHS) were set up through a field location experiment. Combined with the aggregate classification method, the changes in bulk density, total porosity, pH, soluble salt content, microbial biomass carbon, dissolved organic carbon, new carbon, and aggregate organic carbon of coastal saline alkali soil under different treatments were compared. The results showed that the MS and DGHS treatments significantly reduced soil bulk density and increased soil total porosity, water content, and average weight diameter. The pH and exchange sodium percentage decreased significantly under all treatments, and there was no significant difference. DG treatment significantly reduced the soil sodium adsorption ratio. Compared with that in the MS treatment, the soil sodium adsorption ratio of DGLS, DGMS, and DGHS showed a further decreasing trend, with a decrease range of 57%-66%. Compared with MS, soil soluble Na+ decreased by 27.92%, 32.23%, and 20.15% under the DGLS, DGMS, and DGHS treatments, whereas the soil soluble Ca2+ and SO42- contents increased significantly. Compared with that in CK, all treatments could significantly reduce Cl- content, and there was no significant difference among all treatments. Compared with that in MS, microbial biomass carbon and dissolved organic carbon were significantly increased by 113% and 147% by DGMS and 22.81% and 28.24% by DGHS, respectively. The new carbon formation of DGLS, DGMS, and DGHS was 67%, 114%, and 175% higher than that of MS, respectively. The average size proportion of fine aggregates treated by DGLS, DGMS, and DGHS was 29.12% higher than that treated by MS. Straw returning and application of desulfurized gypsum increased the organic carbon content of coarse aggregates and fine aggregates in salinized soil. The average value of new carbon formation in coarse aggregates and fine aggregates treated by DGMS and DGHS was 233% and 142% higher than that treated by MS, respectively. Desulphurized gypsum applied to soil did not lead to soil heavy metal pollution, and the soil heavy metal content of different treatments was lower than the secondary standard of the soil environmental quality standard. These results can provide scientific basis for the improvement and utilization of coastal saline-alkali soil and the comprehensive utilization of industrial and agricultural wastes in the Yellow River Delta.