As a result of adaptation to the environment, the great environmental spatial heterogeneity leads to the high spatial heterogeneity of vegetation status. This coupling may be more apparent in water-limited drylands, where topography is the main determinant of small-scale variation in water availability and energy. Metrics describing this coupling may contribute to the detection of the extension of vegetation reshaped by human intervention and other driven forces. In this study, the heterogeneity index of coupling (HIC) was developed to indicate the coupling between spatial heterogeneity of vegetation status (Hv) and the spatial heterogeneity of topography (HT) in the Loess Plateau in northern China. The 16-day composed MODIS normalized vegetation index (NDVI) with a resolution of 250 m and SRTM DEM were employed to quantify the heterogeneity of vegetation status and the topographical heterogeneity. The results show that HIC varies among geomorphic zones, land cover types, and land cover change categories. Among all land cover types, HIC of sandy areas was the largest, followed by the HIC of the forest, shrub, farmland, and grassland. Among geomorphic zones, the highest HIC value appeared in plains with dense residential areas, followed by sandy land that is frequently reshaped by wind, rocky mountainous areas, hilly and gully loess plateaus, and loess tableland. It was revealed that the alternation of vegetation by human activities and natural disturbances shaped greater HIC. Results of this study approved the effectiveness of the HIC in reflecting the coupling of the vegetation status with topography at regional scale.