This study examines spatiotemporal changes in Land Use Land Cover (LULC) patterns within Habru District, Amhara Region, Ethiopia, between 1985 and 2021. Employing Landsat imagery and a supervised classification approach, we mapped six LULC classes: water body, settlement area, cultivated land, bare land, shrub land, and forest land. Ground control points (GCP) were obtained through field observations to ensured image accuracy. Complementing the remote sensing analysis, focus group discussions (FGDs) and key informant interviews were conducted to understand local perspectives on LULC changes. The analysis revealed significant LULC transformations over the study period. Between 1985 and 2021, there was a significant increase in cultivated land and settlement areas, which expanded from 12.27 % to 0.23 %–42.12 % and 2.58 % of the total area, respectively. Conversely, shrub and forest lands saw a marked reduction during the same period, declining from 71.52 % to 12.88 %–45.35 % and 7.06 % of the total area, respectively. Water body area showed a minor increase, while bare land exhibited negligible change. Agricultural land and settlement area expansion, population growth, land tenure insecurity, economic challenge, and climatic change were identified as key drivers of observed LULC changes. Our findings underscore the urgency of implementing multifaceted interventions to address these drivers and promote sustainable resource use practices. Such actions are critical for safeguarding Habru District's natural resources and ensuring the long-term viability of ecosystem services.