The aim of this study was to assess the LULC changes over 26 years from 1995 to 2021 to find the most changed land use conditions within the 25 km territory of the main river systems of Bangladesh. In addition, the prediction of vulnerable areas for agricultural land use in terms of inundation by river water was also analyzed. The study area includes river networks distributed through eight administrative divisions (Rangpur, Rajshahi, Mymensingh, Sylhet, Dhaka, Khulna, Barishal and Chittagong) of Bangladesh, covering an area of 64,556 km2. The study was conducted by identifying permanent water bodies from NDWI indices and preparing LULC maps that include the five main land use classes (water body, bare land, vegetation, agricultural land, and urban area) in the Google Earth Engine platform using supervised classification. The LULC maps were then analyzed in the ArcGIS® environment. A vulnerability map for agricultural land use was also prepared using a fuzzy expert-based system applying multicriteria analysis. From the land use land cover map of the study area, it was found that among the five land use classes, water bodies, bare land, vegetation, and urban areas increased in size by 3.65%, 2.18%, 3.31% and 2.55%, respectively, whereas agricultural land use significantly decreased by 11.68%. This decrease in agricultural land use was common for the analyzed area of all administrative divisions. According to the vulnerable area map of the eight divisions, more than 50% of the analyzed area of the Khulna and Dhaka divisions and more than 40% of the analyzed area of the Rajshahi, Mymensingh, Sylhet, Barishal and Chittagong divisions were highly vulnerable to agricultural land use due to the possibility of inundation by water. However, approximately 44% of the analyzed area of the Rangpur division was not vulnerable for agricultural land use. The prepared LULC and vulnerability maps can be helpful for the future land use planning of Bangladesh to meet the increasing demand for food production and livelihoods for increasing populations.