This study examines knowledge management (KM) practices and public healthcare workers’ performance in selected public hospitals, in Lagos State, Nigeria. The study adopted a cross-sectional research design; 641 public healthcare practitioners in Lagos State constituted the population of the study and a sample size of 241 was derived using the Rasoft table. The study employed a purposive sampling technique. Primary data were gathered through a self-administered questionnaire, and 197 copies were retrieved representing 81.7 % and later used for analysis. The study employed descriptive statistics and simple regression analysis to derive meaning from the data. The findings showed that knowledge acquisition has a significant effect on public health workers’ effectiveness (β= 0.773, t = 11.221, p-value= .000) and knowledge sharing has a significant effect on public health workers’ effectiveness i.e. public hospitals (β= 0.698, t = 11.894, p-value= .000). The study concludes that knowledge management (KM) significantly affects public health workers’ performance in Lagos public hospitals. The findings equally demonstrate KM as a strategic resource for effectiveness in public healthcare delivery. This study suggests that the Lagos State Government should continue to employ strategies and policies that encourage the acquisition of knowledge among health workers. In addition, health workers in public hospitals should continue to share their professional experience, skills, and ideas among themselves to offer more effective public medical service delivery.
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