We may associate Olympic gymnasts with extreme precision and coordination, but in nature, precise movements are performed without much notice every day. Complex environments pose as an obstacle to steady locomotion, and yet animals appear to cope with these obstacles effortlessly. This accurate locomotion requires serious neural coordination. How the brain coordinates accuracy during movement is still unclear, but new research suggests the different neurons of the pyramidal tract may be involved.The pyramidal tract consists of nerve fibers connecting the primary motor cortex of the brain with motor neurons in the brain stem and anterior spinal cord. These connections are extremely important, as pyramidal tract neurons control all voluntary motions and damage to the region results in severe motor disability.Scientists have long known two different types of neuron exist in the pyramidal tract: large, fast-conducting neurons and smaller, slow-conducting neurons. Erik Stout and Irina Beloozerova of St Joseph's Hospital and Medical Center, AZ, USA, looked how these two types of neuron might control accurate locomotion. The two researchers trained cats to run on a flat track and on a horizontal ladder track, where the cats had to step precisely on the rungs of a horizontal ladder, and never in the gaps between rungs. Stout and Beloozerova then recorded the activity from slow-conducting and fast-conducting pyramidal tract neurons, to see whether there were differences in their activity patterns between different motions.Both slow and fast pyramidal tract neurons had different activity patterns during flat versus ladder running. Slow-conducting neurons, however, changed their activity in a much more concerted way than fast-conducting neurons. During the late stance and early swing phase of each stride on the ladder, slow-conducting neurons increased their average rate of discharge and decreased their discharge variability. Slow-conducting neurons also increased the magnitude of stride-related frequency modulation during ladder running. While fast-conducting neurons displayed some similar trends in their modulation between different locomotor tasks, the differences were small in magnitude and often insignificant.Because there were very few kinematic differences between flat and ladder running, the changes in slow-conducting neuron activity are probably related to the high accuracy demands of ladder running. This suggests that slow-conducting neurons are more important than fast-conducting neurons for the control of precise movement. The proximate mechanisms by which slow-conducting neurons control precise limb placement are still elusive. Stout and Beloozerova note that while fast-conducting neurons chiefly influence distal musculature, slow-conducting neurons can influence both proximal and distal musculature. They propose that maybe proximal limb musculature plays a greater role in accurate paw placement than previously thought.As technology for instrumenting small slow-conducting neurons improves, perhaps neuroscientists can narrow in on the fine controls of accurate locomotion. Eventually, we may know exactly how slow neurons help us tread carefully.
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