The evolution of large-scale paleo-uplifts within sedimentary basins controls the sedimentary provenance, depositional systems and hydrocarbon distributions. This study aims to unravel changes in paleo-geomorphology, interpret sedimentary sequence evolution, and investigate favourable reservoir types and the hydrocarbon distribution during the buried stage of a long-term eroded paleo-uplift, taking the Lower Cretaceous Qingshuihe Formation (K1q) in the Junggar Basin as an example. These research topics have rarely been studied or are poorly understood. This study integrates current drilling production data with outcrop and core analyses, drilling well logs, 3D seismic data interpretations, grading data, physical property comparisons and identified hydrocarbon distributions.After more than 20 million years of differential river erosion and weathering in arid conditions, the large-scale Chemo paleo-uplift within the hinterland area of the basin formed a distinctive valley–monadnock paleo-geomorphology prior to the deposition of K1q. Since the Early Cretaceous, tectonic subsidence and humid conditions have caused the base level (lake level) to rise, leading to backfilling of valleys and burial processes. Two systems tracts in the target strata of K1q, consisting of distinctive depositional systems, can be identified: (1) a lowstand systems tract (LST), which is confined within incised valleys and is mainly composed of gravelly braided rivers and rarely occurring debris flows and (2) an extensive transgressive systems tract (TST), which developed into an almost flat landform and consists of braided river delta to lacustrine depositional systems. Overall, the physical properties of braided river reservoirs in the LST are better than those of the braided river delta reservoirs in the TST. However, the inhomogeneous distributions of carbonate cements cause differences in the physical properties of conglomerate reservoirs in the LST. However, for sandstones in both the LST and TST, coarser grain sizes and better sorting result in better physical properties. Altogether, four types of reservoir can be identified in the study area: Jurassic inner monadnock reservoirs, K1q LST stratigraphic onlap reservoirs, LST structural reservoirs and TST structural reservoirs.