Prevalence Of Lactose Intolerance Research Articles

Lactose Intolerance in Jazan: Awareness and Impact

Background: Lactose intolerance is a frequent disorder characterized by gastrointestinal symptoms (such as nausea, bloating, and discomfort) following dairy product consumption. LI can be considerably decreased with simple understanding of symptoms and the use of milk substitutes. Aim: The goal of this study was to look into the prevalence of lactose intolerance and its relationship to nutrition and dietary habits in Jazan, Saudi Arabia. Methods: This study used a cross-sectional descriptive design with a sample of 283 participants who met the qualifying requirements. A questionnaire was used to collect the data, which was then analyzed using statistical tools for social sciences (SPSS) and Microsoft Excel. Results: Dairy/dairy products were highly consumed on daily basis (64.7%) accompanied by abdominal distention and gases (18%), yet, only 13.8% had been diagnosed with lactose intolerance. The magnitude of lactose intolerance was mainly in late childhood (11-20 years) and emerging adulthood (21-30 years) (56.4%). only 36% had good knowledge about the disorder, with females had significantly higher levels of awareness compared to males (p<0.05). Conclusion: Almost one-third of the population in Jazan had good knowledge on lactose intolerance with females having significantly higher levels.

Carbohydrate composition of cow's milk and plant-based milk alternatives

The prevalence of lactose intolerance is one of the factors driving consumers toward plant-based milk alternatives (PBMA). This study aimed to analyze the carbohydrate profile of cows' milk (regular and lactose-free from both pasteurized and UHT milks; n = 80) and PBMA (n = 60) by HPLC. The study revealed that there was no significant difference in the energy content and total carbohydrate content between regular milk and lactose-free milk. Although milk and PBMA are entirely different food matrices, some PBMA types, as soya and coconut, may have energy contents and total carbohydrate contents comparable to those of milk. Furthermore, the variability observed in total carbohydrate content, as well as in carbohydrate profile, both between PBMA types and within samples of the same type, arises not only from variations in raw materials but also from the number of dilutions of the vegetable extract and the addition of different types and levels of carbohydrates, such as sucrose, fructose, or sorbitol, during PBMA manufacture. Although, milk presents a regular carbohydrate composition, differing solely between presentations (regular/lactose-free), the PBMA differs significantly between types and among the same type, not being for that reason regarded as a milk substitute.

Fortification of Pea and Potato Protein Isolates in Oat-Based Milk Alternatives; Effects on the Sensory and Volatile Profile.

Oat-based milk alternatives (OMAs) are an important alternative to bovine milk, with prevalence of lactose intolerance, as well as soy and nut allergies limiting consumers options. However, OMAs are typically lower in protein content than both bovine milk and soy-based alternatives, with protein quality limited by low lysine levels, which can reduce protein digestibility. Addition of alternative plant proteins may increase the quantity of protein, as well as balancing the amino acid profile. However, plant-based proteins have additional sensory qualities and off-flavours, which may lead to undesirable characteristics when introduced to OMAs. This study aimed to assess the effect of pea and potato protein addition on the sensory profile, volatile profile, colour, and particle size in an OMA control product. Results demonstrated that pea protein contributed to a bitter and metallic taste, astringent aftertaste, and a significantly increased overall aroma correlated with higher levels of key volatiles. Whilst potato protein resulted in less flavour changes, it did lead to increased powdery mouthfeel and mouthcoating supported by a substantially increased particle size. Both protein fortifications led to detectable colour changes and a staler flavour. Fortification of OMA product with the pea protein led to significant sensory, volatile and physical changes, whilst the potato protein led to predominantly physical changes. Further investigation into alternative plant-based proteins is necessary to optimise sensory qualities whilst increasing protein content and the amino acid profile.

Prevalence of lactose intolerance among natives and expats in Kuwait

Prevalence of lactose intolerance among natives and expats in Kuwait

Prevalence of cow´s milk allergy and lactose intolerance among Mexican late adolescents

To determine the prevalence of cow´s milk allergy and lactose intolerance in a sample of late adolescents. Through a population-based study, data corresponding to students with aged 15 to 18 years were analyzed. A total of 1992 adolescents was analized. The prevalence of cow´s milk allergy was 1.4% (95% CI: 0.2% to 0.8%) and the prevalence of lactose intolerance was 0.5% (95% CI: 0.2% to 0.8%). Adolescents with cow´s milk allergy had fewer gastrointestinal symptoms (p = 0.036), but more skin (p < 0.001) and respiratory (p = 0.028) ailments than adolescents with lactose intolerance. The manifestations associated with cow's milk consumption in late adolescents seem to correspond mainly to cow´s milk allergy than to lactose intolerance.

Lactose intolerance prevalence in Saudi Arabia: A cross-sectional analytic study

Background: Lactose intolerance is a common worldwide medical condition that affects around two-thirds of the global population, with variations across regions. South American, Asian, and African individuals tend to develop lactase deficiency, while northern Europe and northern Indians may maintain lactose digestion into adulthood. West African and Arab individuals also suffer from lactose intolerance. Research on lactose intolerance prevalence in Saudi Arabia can provide valuable data for the medical field and general population. Methodology: A cross-sectional descriptive study was conducted in the Riyadh region, the capital of Saudi Arabia. The study population consisted of 274 patients, with an age range from 18 years old to 70 years old. Results: Out of 274 patients, 45.3% tested positive for lactose intolerance. Males constituted 58% of the sample, and 30.3% of positive results were from male patients, while 15% were from females. A significant association was found between positive lactose tests and male gender (p &amp;lt; 0.05). Chronic conditions were present in 53.4% of patients, and 23.9% of them had positive lactose tests. A significant association was observed between positive lactose tests and medication use (p &amp;lt; 0.05). Regarding weight loss, 47.6% of patients with positive lactose tests experienced no weight loss, 19.2% reported weight loss, and 2% had stable weight. An association was found between positive lactose tests and weight loss (p &amp;lt; 0.05). Conclusion: The study found significant associations between positive lactose test results and gender, medication use, weight loss, and abdominal pain, indicating lactose intolerance is a multifaceted condition influenced by multiple factors. Further research is needed to understand the complex interplay and establish causality using longitudinal study designs.

Prevalence of Lactose Intolerance in Patients with Hashimoto Thyroiditis and Impact on LT4 Replacement Dose.

Purpose: to determine lactose intolerance (LI) prevalence in women with Hashimoto’s thyroiditis (HT) and assess the impact of LI on LT4 replacement dose. Methods. consecutive patients with HT underwent Lactose Breath Test and clinical/laboratory data collection. Unrelated gastrointestinal disorders were carefully ruled out. Lactose-free diet and shift to lactose-free LT4 were proposed to patients with LI. Results: we enrolled 58 females (age range, 23–72 years) with diagnosis of HT. In total, 15 patients were euthyroid without treatment, and 43 (74%) euthyroid under LT4 (30 of them with a LT4 formulation containing lactose). Gastrointestinal symptoms were present in 84.5% of patients, with a greater prevalence in change in bowel habits in lactose-intolerant patients (p < 0.0001). The cumulative LT4 dose required did not differ in patients with or without LI. No significant difference in both TSH values and LT4 dose were observed in patients shifted to lactose-free LT4 and diet at 3 and 6 months compared to baseline. Conclusion: the prevalence of LI in patients with HT was 58.6%, not different from global prevalence of LI. In the absence of other gastrointestinal disorders, LI seems not to be a major cause of LT4 malabsorption and does not affect the LT4 required dose in HT patients.

Sugarcane juice Kheer: A sweet meal for lactose intolerant people

With the prevalence of lactose-intolerance, people are looking for non-dairy options. An attempt was made to prepare shelf stable sugarcane kheer without milk. Sugarcane kheer was prepared by cooking the juice with boiled rice in different ratios i.e. 2:1, 4:1 and 6:1. Based on preliminary sensory trials, sugarcane juice to rice ratio 4:1 obtained highest overall acceptability and was selected for product development and shelf life studies. Storage studies at refrigerated (4–7oC) temperature revealed that TSS, pH and acidity remained unaffected whereas total sugars, reducing sugars and bioactive constituents (Ascorbic acid, total phenolics and antioxidant activity) decreased significantly (p<0.050) during progression of storage. Prepared kheer was shelf stable for two months under refrigerated conditions with high overall acceptability.

Prevalence of lactose intolerance and malabsorption among children of two ethnic groups from the urban areas of Malaysia and its relation to calcium intake and bone health status.

This study aimed to determine the prevalence of LI and lactose malabsorption (LM) in Malay and Chinese children and examine its relationship with calcium intake (CI) and BHS. A total of 400 children participated in this study. The prevalence of lactose tolerance (LT) was assessed using hydrogen breath test, LT test, and visual analogue scales. Assessment of CI was performed using a 24-h dietary recall interview (24-h DR) and food frequency questionnaire (FFQ). Calcaneal broadband ultrasound attenuation (BUA) was measured using a quantitative ultrasonometer. The prevalence of LI among Chinese children (37%) was significantly higher (p = 0.002) than among Malay children (22.5%). However, 61.5% of Malay and 54.5% of Chinese children were found to have LM. CI of the children fulfilled 30.5% and 33.9% of the Malaysian recommended CI (1300mg/day) for 24-h DR and FFQ, respectively. The BUA score of Malay children was significantly higher (p < 0.001) than that of Chinese children. However, LT and CI were not correlated with BHS (p > 0.05, respectively). LI was diagnosed among Malay and Chinese children. However, the higher prevalence of LM is rather worrying as it could develop to LI. The prevalence possibly has been worsened by insufficient CI. Thus, effective approaches to increase CI are highly needed as bone development occurs rapidly at this age and is important for the attainment of the optimum peak bone mass during late adolescence.

Chemical and Physical Characteristics of Fermented Beverages from Plant-Based Milk with the Addition of Butterfly Pea Flower (Clitoria ternatea L.) Extracts

The prevalence of lactose intolerance in Indonesia is increasing now. Almond milk (A), soymilk (S), and almond-soy milk (A-S) are plant-based milks that can be used to prevent lactose intolerance. Besides that, in Indonesia, about 45% of an estimated 25.300 child deaths is attributable to air pollution. Air pollution is a source of free radicals that are hazardous to the body. The butterfly pea extract has high antioxidant activity. Antioxidant can counteract free radicals. The aim of this research is to know the chemical and physical characteristics of fermented beverages from A, S, and A-S with the addition of (10%) butterfly pea flower extracts. These beverages were produced by fermentation with Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus salivarius, and Bifidobacterium breve. The research method is Completely Randomized Design (CRD). The research revealed that fermented beverage from A has the highest antioxidant activity and protein content. Hedonic test revealed that panellists prefer aroma, taste, and texture of fermented beverage from A-S; however, the colour of fermented beverage from A is more preferred.

Prevalence of lactose intolerance and nutrients intake in an older population regarded as lactase non-persistent.

Energy and nutrient intakes of community-dwelling older adults in Indonesia are inadequate whereby milk consumption is among the lowest in the world. Lactose intolerance is probably one of the reasons for such low milk consumption, but information on the burden of this problem and its consequences for dietary intake is lacking. We obtained data on the prevalence of lactose intolerance and dietary intakes in Indonesian older outpatients, thereby comparing dairy users and non-dairy users. A cross-sectional study was conducted in 2019 involving 103 community-dwelling older adults in the outpatient geriatric clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta. A structured questionnaire was used to categorize participants as dairy- or non-dairy users. Food records were collected to assess nutrients intake from the diet. The prevalence of lactose intolerance (LI) was estimated based on the results of the hydrogen breath test (HBT) and on symptoms of lactose malabsorption. The difference in LI prevalence between dairy- and non-dairy user group was presented as a prevalence ratio (with 95% confidence interval). Chi-square tests, t-test, and Mann-Whitney tests were used to evaluate differences in demographic and clinical characteristics, as well as in nutrient intake profiles between dairy and non-dairy users. The prevalence of lactose intolerance amounted to 66% (57-75%), 54% (37-70%), and 73% (61-84%) in the total population, dairy- and non-dairy users, respectively. Lactose intolerance tended to be higher among non-dairy users (PR 1.36 95% CI 0.99-1.89). On the other hand, we found no pronounced differences in symptoms of lactose intolerance between dairy and non-dairy users. The overall mean protein, calcium, vitamin D, and vitamin B12 intakes of the older adults were low. Intakes of protein, calcium, vitamin D and vitamin B12 were higher among dairy than among non-dairy users. This study uncovered the large size of the lactose intolerance problem in Indonesian older adults. Especially in non-dairy users, the intakes of proteins and some micronutrients are a concern. Strategies to tackle lactose intolerance are most relevant as to open the door for more nutrient-dense foods in the diet of Indonesian older adults.

Ready-to-eat blueberries as fruit-based alternative to deliver probiotic microorganisms and prebiotic compounds

The prevalence of lactose intolerance, milk protein allergies, and the increasing vegan population have led to a growing demand for probiotic products based on non-conventional food matrices. In this study, the potential use of fresh blueberries as carriers of Lacticaseibacillus casei CECT 9104 and Bifidobacterium animalis subsp. lactis CECT 8145 incorporated into alginate-based prebiotic coatings was evaluated. Protective effect of inulin + oligofructose on probiotic viability, microbiological and sensory quality of fruits, and also, antagonistic effects of probiotics on co-inoculated E. coli O157:H7 and L. innocua were the main parameters studied along 14 days of refrigerated storage. A protective effect was observed since prebiotic enrichment allowed maintaining both L. casei and B. lactis viability above the minimum recommended levels (106 CFU/g) up to the end of storage, and therefore, ensuring their beneficial health action. Regarding safety issues, both probiotics exerted a biocontrol effect on inoculated L. innocua with reductions up to 2.31 log. Moreover, enrichment of blueberries with B. lactis through the application of prebiotic coatings maintained quality and sensory characteristics for 14 days at 5 °C. Thus, the development of functional blueberries coated with prebiotic-probiotic mixtures was achieved. These ready-to-eat fruits constitute novel, healthy and multifunctional alternatives of non-dairy probiotic foods that would allow meeting the current consumer demand.

Response to a Research Article Entitled: Prevalence of Lactose Intolerance and its Association with Malnutrition in Children

With clearly outlined prospects for research, I congratulate Dr. Neel Kanth and colleagues for their interesting study on the “Prevalence of lactose intolerance and its association with malnutrition in children”, published in a recent issue of the National Journal of Health Sciences (NJHS, Volume 4, Issue 3, 2019) [1]. The high prevalence of lactose intolerance documented by the authors is confirmed by a recent meta-analysis, which found a lactose malabsorption among adults and children aged 10 years or older of 58% in Pakistan [2]. The 2018 Pakistan National Nutrition Survey also showed that 40.2% children were stunned, 28.9% were underweight, and 17.7% were wasted [3]. The authors rightly pointed out that further research is urgently needed to better understand the association of lactose intolerance and malnutrition in children [1]. However, in my opinion, here are two aspectsworth mentioning.

The role of small intestinal bacterial overgrowth and false positive diagnosis of lactose intolerance in southwest Hungary-A retrospective observational study.

BackgroundLactose intolerance is a frequent gastrointestinal disease affecting 47% of the Eastern European population. Small intestinal bacterial overgrowth (SIBO) leads to carbohydrate malabsorption and therefore to false results during lactose breath and tolerance tests.ObjectivesWe aimed to assess the prevalence of lactose maldigestion and intolerance in Hungary and to investigate the role of combined diagnostic method and testing for SIBO in reducing false results.MethodsWe retrospectively analyzed data from 264 adult symptomatic patients who underwent 50g lactose breath and tolerance tests in parallel over a one-year period at our center. A ≥20 ppm elevation of H2 or less than 1.1 mmol/l rise of blood glucose was diagnostic for lactose maldigestion. Patients with maldigestion who had symptoms during the test were defined as lactose intolerant. Patients with an early (≤90 min) significant (≥20 ppm) rise of H2 during lactose and/or lactulose breath tests were determined to have SIBO. Patients with slow/rapid oro-cecal transit and inappropriate preparation before the test were excluded.Results49.6% of the 264 patients had lactose maldigestion, and 29.5% had lactose intolerance. The most frequent symptom was bloating (22.7%), while 34.8% of the study population and 60% of the symptomatic patients had SIBO. In 9.1% and 9.8% of the patients, the lactose breath and tolerance test alone gave false positive result compared with the combined method. SIBO was present in 75% of the false positives diagnosed with breath test only.ConclusionsThe prevalence of lactose intolerance is lower in Hungary compared to the Eastern European value (29.5% vs 47%), so it is worth performing a population-based prospective analysis in this area. A combination of lactose breath and tolerance tests and the careful monitoring of results (with early H2 rise, lactulose breath test, etc.) can decrease the false cases caused by e.g. SIBO.

Prevalence of Lactose Intolerance in Healthy Medical Students

Prevalence of Lactose Intolerance in Healthy Medical Students

Prevalence of lactose intolerance and its association with breakfast consumption in Iranian adolescents

PurposeLactose intolerance (LI) is a disturbing gastrointestinal disorder with a high prevalence in all parts of the world, especially in Asian countries. The purpose of this study is to investigate the prevalence of LI in students from Zabol, Iran.Design/methodology/approachBased on cluster random sampling method, 887 subjects were selected for the study. Of all, 54.7 per cent of the students were boys. The mean (±SD) of age, weight and body mass index (BMI) for participants were 13.27 ± 1.14 years, 42.12 ± 10.25 kg and 18.7 ± 3.9 kg/m2, respectively. LI was assessed using a validated self-administered questionnaire. After measuring the anthropometric indices, students were asked to ingest 200cc of milk. The questionnaires were completed 2 h after the ingestion of milk.FindingsIn total, 25.8 per cent of the adolescents had LI. Of all, 1, 4.6, 11, 30.2 and 53.2 per cent of affected students had severe, relatively severe, moderate, relatively mild and mild LI, respectively. The association between LI and gender, and BMI was not significant (p&gt; 0.05 for both); however, the association between LI and the history of LI in parents (OR = 2.06; 95 per cent CI: 1.47-2.88;p&lt; 0.001), and breakfast consumption was significant (OR = 1.49; 95 per cent CI: 1.04-2.14;p= 0.028).Originality/valueAlthough the prevalence of LI is noticeable, majority of adolescents had mild and relatively mild LI. Parents’ history and breakfast consumption are related to the rate of LI prevalence. Appropriate strategies should be considered to prevent breakfast skipping.

LAKTOZ İNTOLERANSIN PREVALANSI, TEŞHİSİ VE LAKTOZSUZ BESLENME TAVSİYELERİ

Lactose is a disaccharide found only in milk, and after weaning, the synthesis of lactase, which breaks down lactose, stops or decreases in most individuals. This condition, known as lactose intolerance, results in the inability of the digestion of milk and is very common in the world. Because of the single nucleotide polymorphisms occurring on the lactase gene, the lactase enzyme can be synthesized for life in some individuals. The prevalence of this condition called lactase persistence varies according to ethnic groups. Although there are various methods for the diagnosis of lactose intolerance, observation of symptoms is often sufficient for the diagnosis of the disease. Those who have lactose intolerance should apply a life-long lactose-free diet. Since milk is a rich source of some important nutrients such as calcium, it is important for lactose intolerance patients to meet their needs like calcium from foods with low lactose content such as cheese and yogurt. In this study, information about lactose intolerance was given and lactose intolerance prevalence, diagnosis methods, and lactose-free diet were examined. This study aims to increase the lactose intolerance awareness of both patients and food industry stakeholders.

Fatty acid specific δ13C values reveal earliest Mediterranean cheese production 7,200 years ago.

The earliest evidence for cheese production in the Mediterranean is revealed by stable carbon isotope analyses of individual fatty acids in pottery residues from the Dalmatian coast of Croatia. Lipid residue data indicate the presence of milk in the earliest pottery, Impressed Ware, by 5700 cal. BCE (7700 BP). In contrast, by 5200 cal BCE (7200 BP), milk was common in refined Figulina pottery, meat was mostly associated with Danilo ware, cheese occurred in Rhyta, and sieves contained fermented dairy, representing strong links between specific function and stylistically distinctive pottery vessels. Genetic data indicate the prevalence of lactose intolerance among early farming populations. However, young children are lactase persistent until after weaning and could consume milk as a relatively pathogen-free and nutrient rich food source, enhancing their chances of survival into adulthood. Fermentation of milk into yogurt and cheese decreases lactose content. The evidence for fermented dairy products by 5200 cal BCE indicates a larger proportion of the population was able to consume dairy products and benefit from their significant nutritional advantages. We suggest that milk and cheese production among Europe’s early farmers reduced infant mortality and helped stimulate demographic shifts that propelled farming communities to expand to northern latitudes.

Prevalence of lactose intolerance in patients with diarrhea-predominant irritable bowel syndrome: data from a tertiary center in southern China

BackgroundSymptoms associated with lactose intolerance (LI) and diarrhea-predominant irritable bowel syndrome (IBS-D) are almost the same. These disease entities are difficult to differentiate clinically. In practice, differential diagnosis depends on self-reported patient milk intolerance. However, there is limited data on the prevalence of LI in China. The aim of this study was to investigate the prevalence of LI in IBS-D patients and asymptomatic healthy controls.MethodsLactose malabsorption (LM) was diagnosed by a lactose hydrogen breath test (HBT) and was defined by peak breath H2 excretion over the baseline level of ≥ 20 ppm. LI-related symptoms were monitored for 8 h following lactose administration. LI was defined in LM patients with positive symptoms during the observation time. Patients with IBS-D were additionally asked if they were intolerant to milk.ResultsA total of 109 eligible IBS-D patients (Rome III criteria) and 50 healthy controls were enrolled in this study. Except for hydrogen non-producers, the prevalence of LM did not differ between IBS-D patients and the control group (85%, 82/96 vs 72%, 34/47; P = 0.061). There was, however, a higher LI prevalence in IBS patients than in healthy subjects (45%, 43/96 vs 17%, 8/47; P = 0.002). Sensitivity, specificity, and positive and negative predictive values of self-reported milk intolerance for detecting LI were 58, 58, 53, and 63%, respectively.ConclusionsPrevalence of LI is significantly higher in IBS-D patients than in healthy subjects. Self-reported milk intolerance is a poor diagnostic predictor of LI.

Lactose Intolerance and Symptom Pattern of Lactose Intolerance among Healthy Volunteers.

ABSTRACTAimsTo see the prevalence of lactose intolerance (LI) and related symptoms following oral lactose challenge in healthy volunteers.Materials and methodsSymptoms of abdominal pain, nausea, borborygmi, flatulence, and diarrhea were noted for 24 hours and blood glucose was estimated at 0 hour and 30 minutes after 25 gm oral lactose load to healthy volunteers. Failure to rise blood glucose level ≥ 1.1 mmol/l at 30 minutes after lactose intake from fasting level was taken as lactose malabsorption (LM), i.e., LI.ResultsA total of 166 volunteers (123 males, 43 females) with a mean age 34.78 ± 11.45 years participated in this study. Lactose intolerance was found among 85.54% (n = 142, M = 104, F = 38). The main symptoms of LI were diarrhea (n = 83, 58.4.0%), borborygmi (n = 81, 57.04%), abdominal pain (n = 35, 24.65%), and flatulence (n = 27, 19.0%).ConclusionLactose intolerance among healthy adults may be common in Bangladesh. Diarrhea and borborygmi were mostly associated symptoms of LI.How to cite this articleSaha M, Parveen I, Shil BC, Saha SK, Banik RK, Majumder M, Salam MU, Nazmul Islam ASM. Lactose Intolerance and Symptom Pattern of Lactose Intolerance among Healthy Volunteers. Euroasian J Hepato-Gastroenterol 2016;6(1):5-7.