In the United States and globally, it is well documented that human milk and breastfeeding rates at discharge from the NICU are suboptimal. This presentation describes an innovation prenatal lactation intervention to improve human milk and breastfeeding outcomes. As part of standard prenatal care, families will have the opportunity to participate in group prenatal care (centering model). In addition, all families will receive a personalized 1:1 prenatal lactation intervention tailored to their newborn’s diagnosis. The concept is that all families (regardless of their prenatal preference for newborn feeding) receive the same evidence-based human milk and breastfeeding information. The content is tailored to how human milk is a life-saving medical intervention based on their newborn’s diagnosis. Through the Center for Fetal Diagnosis and Treatment, families are scheduled for a 1:1 personalized prenatal lactation consultation as part of their routine prenatal care. There is no charge to the family for this service. The consultation last on average 60 minutes or more, dependent on the families’ learning needs. Families have the opportunity to practice with pump assembly and operation, and a personalized plan is developed based on any lactation risk factors and the newborn’s diagnosis. Implementation of an innovative prenatal lactation intervention has resulted in pumping initiation rates of 99% in our institution. In addition, our human milk rates at discharge are well over 75%. We will also share newly published, diagnosis-specific outcomes for infants with congenital diaphragmatic hernia as well as spina bifida. This model is replicable in other institutions. This can lead to improved human milk and breastfeeding outcomes during the NICU stay and beyond.