Endonasal dacrocystohinostomy (DCR) is the surgery used for chronic dacrocystitis, where the patient has epiphora caused by blocking of nasolacrimal duct, leading to collection of lacrimal fluid in the sac which ends in inflammation of the lacrimal sac. As the success rate of endonasal DCR varies from 50---97%, various different methods are used to have high success rate. It is very important to make the ostium at the level of the common canaliculus. If the exposure of lacrimal sac is not sufficient then even though Mitomycin is applied the rate of failure remains high. INTRODUCTION: Epiphora is the most bothersome complication of lacrimal system obstruction. Other than it relapsing dacrocystitis, dacryocele and dacryolithiasis, latter being quite rare, are the other indications of dacrocystorhinostomy. DCR is a surgical procedure in management of obstructive epiphora. Obstructive epiphora finds today his best solution with a surgical procedure Dacrocystorhinostomy by nasal endoscope. The lacrimal flow is diverted into nasal cavity through an artificial opening made at the level of lacrimal sac. DCR can also be performed by an external approach. It is called external DCR. In comparison of both, endonasal DCR has certainly many advantages; minimally invasive procedure, better aesthetic results with no cutaneous scar, preserves lacrimal pump system, faster resumption to daily activities, any intranasal pathology that might have caused obstruction can be addressed at the same time, active infection of the lacrimal system is not a contraindication to the surgery, it is much less bloody than the external approach, the per-operative time is shorter. If the obstruction is in puncta or canaliculus, endonasal; DCR will not help. Mitomycin—C is an alkaline agent used as anticancer, isolated from streptomyces Caespitosus. It inhibits the synthesis of DNA, cellular RNA and proteins in the rapidly growing cells. It has the ability to suppress fibrosis and vascular growth hence can reduce possibility of stenosis of the newly created ostium. We used Mitomycin –C (0.5 mg/ml) for 5 minutes over osteotomy site. MATERIAL AND METHODS: Three hundred patients (300), who presented with epiphora, were selected and operated for Endonasal DCR. The patients ranged from 5 years to 85 years of age. One hundred and thirty nine (139) were males and one hundred and sixty one (161) were females. All of them had epiphora which was not responding to medical line of treatment. Some of them had relapsing dacrocystitis, some had persistent purulent, sticky discharge from eye, and some had lacrimal abscess or fistula. All the patients were examined by ophthalmologist prior to surgery. The clinical evaluation included probing of nasolacrimal system and lacrimal irrigation. The nasal cavity had an adequate examination using 0 degree Endoscope and intranasal pathology that might have caused the obstruction was determined preoperatively. The indication for endonasal approach included distal nasolacrimal duct obstruction. All the patients were examined by an ophthalmologist prior to the surgery. DOI: 10.14260/jemds/2014/2641