Lack Of Previous Data Research Articles

Gender differences in correlation of biochemical parameters with the severity of COVID pneumonia and the need for oxygen/mechanical support

Background:COVID-19 pandemic had caused a global medical, economic and social problems. High infection rate, heterogenous presentation, lack of previous data and no standardized treatment had led to a need for further analysis, in order to be prepared for any potential new pandemics. We analyzed any possible correlation between gender, laboratory findings and severity of disease with need for oxygen or mechanical ventilation support. Methods: 100 patients with confirmed SARS-CoV-2 virus infection enrolled. Baseline characteristics that included age, sex, smoking history, BMI, oxygen therapy or mechanical ventilation support need were recorded. Type and severity of radiological finding determined by chest CT scan. Results: Majority of our patients were over 61 years old (58.6%), male (57.6%), and had severe radiological finding (bilateral pneumonia 29.3%, ARDS 35.4%), with only 20.2% had not required any oxygen supplementation. Regarding gender and laboratory findings, men have shown statistically significant higher values of CRP, lymphocytes, LDH and ferritin (96.4 vs 87.1, p=0.014; 1.17 vs 0.84, p=0.048; 674.8 vs 609.1, p=0.031; 1263 vs 578.4, p=0.001, respectfully). Severe radiological finding had shown positive correlation with the need for HFNC and/or (N)IMV (p=0.021 and p=0.032. respectfully), as well as with higher values of WBC, LDH and ferritin (p=0.042, p=0.035 and p=0.017. respectfully). Conclusions: There is a difference between presentation of the disease, as well as analyzed laboratory markers between sexes. The difference is most likely multifactorial and should require further research in order to discover other risk and prognostic factors.

Domain-Hallucinated Updating for Multi-Domain Face Anti-spoofing

Multi-Domain Face Anti-Spoofing (MD-FAS) is a practical setting that aims to update models on new domains using only novel data while ensuring that the knowledge acquired from previous domains is not forgotten. Prior methods utilize the responses from models to represent the previous domain knowledge or map the different domains into separated feature spaces to prevent forgetting. However, due to domain gaps, the responses of new data are not as accurate as those of previous data. Also, without the supervision of previous data, separated feature spaces might be destroyed by new domains while updating, leading to catastrophic forgetting. Inspired by the challenges posed by the lack of previous data, we solve this issue from a new standpoint that generates hallucinated previous data for updating FAS model. To this end, we propose a novel Domain-Hallucinated Updating (DHU) framework to facilitate the hallucination of data. Specifically, Domain Information Explorer learns representative domain information of the previous domains. Then, Domain Information Hallucination module transfers the new domain data to pseudo-previous domain ones. Moreover, Hallucinated Features Joint Learning module is proposed to asymmetrically align the new and pseudo-previous data for real samples via dual levels to learn more generalized features, promoting the results on all domains. Our experimental results and visualizations demonstrate that the proposed method outperforms state-of-the-art competitors in terms of effectiveness.

The Level of utilization and Satisfaction of Complete Denture Treatment Provided in Fiji from 2010-2016

BACKGROUND: Wearing dentures helps rehabilitate the oral health status for the older people. Due to lack of previous data, this objective of this study was to determine the level of utilization and satisfaction of complete denture treatment at dental clinics in Fiji. 
 
 MATERIALS & METHODS: A cross sectional descriptive study was conducted on 85 edentulous patients and dentures at the Fiji National University (FNU) teaching dental clinic from 2010-2016.Patients who utilized the dentures fabricated at FNU and identified as complete denture patients from 2010-2016 were included in this study. Data was collected using the denture assessment form and Oral Health Impact Profile for Edentulous Patients (OHIP-EDENT) questionnaire. Correlation test was done and p less than 0.05 was considered as level of significance. 
 
 RESULTS: Participants were between the age range of 40-79 years with majority being male (54%). Greater level of satisfaction noted among 60-69 years male participants and those wearing the dentures for 3-4 years than other groups. Difficulty in chewing (40%) and food catching underneath the denture (33%) were common denture related complains. One thirds of participants reported of uncomfortable dentures while 24% had sore spots due to their dentures. More than two thirds of them, (71%) were unable to eat and enjoy food and for most patients, the vertical dimension (94%), esthetics assessment (94%), tooth selection (91%), boarder extension (78%), posterior seal (99%) and centric relation (99%) were acceptable. Patients with acceptable vertical dimension (46.1±7.6), acceptable esthetics (45.8±7.9) and boarder extension (48.0±7.2) showed greater satisfaction level compared to those with unacceptable denture characteristics. 
 
 CONCLUSION: This study highlighted that satisfaction among recent denture wearers was low and majority participants portrayed poor understanding regarding denture aftercare and hygiene. It can be recommended for the teaching institutes and dental clinics to evaluate the quality of treatments and help to improve the quality of services being provided to the patients. Further study is needed to determine the in- depth perceptions of denture wearers. It also can be recommended for the patients to take heed of the post operative denture hygiene instructions being given.

Use of a species-rich and highly eutrophic tropical estuary in the South Atlantic by Pleuronectiformes (Teleostei: Acanthopterygii)

Abstract: A total of 1,471 specimens of 16 species of flatfishes (Pleuronectiformes) were caught during 48 sampling campaigns between July 2005 and June 2007 at ten stations in Guanabara Bay, Rio de Janeiro, Brazil. Paralichthyidae was the dominant family, with Etropus crossotus as the dominant species. The outer stations, especially those on the western side of the lower estuary, were distinguished as a result of their higher abundance of flatfishes and number of species. The spatial distribution of E. crossotus and its population structure indicate that this species is an estuarine resident despite the apparent reduction in its area of occupation within the estuarine complex. Among the other species, nine were classified as marine stragglers (Achirus declivis, Bothus ocellatus, Cyclopsetta chittendeni, Etropus longimanus, Paralichthys orbignyanus, P. patagonicus, Syacium micrurum, Symphurus diomedeanus and Trinectes paulistanus) and three as estuarine opportunists (Bothus robinsi, Citharichthys macrops and Syacium papillosum); another three could not be classified due to the small number of captures or lack of previous data (S. tessellatus, A. lineatus and C. spilopterus).

P119] Dosimetric measurements of the personnel in children’s nuclear medicine unit

Purpose Our study involves the dosimetric measurements of the personnel working at Children’s hospital nuclear medical unit. The daily work of the unit involves SPECT/CT as well as PET/CT examinations. The personnel of the unit consist of three medical doctors, six technologists, one nurse and two medical physicists. Lack of previous data regarding dosimetric measurements of the personnel involved in pediatric examinations illustrated the necessity for such data. Methods All staff was carrying chest as well as finger’s (TLD) dosimeters during daily practices. Dosimeters’ reading were analyzed by the National Committee of Atomic Energy and the values of personal depth dose equivalent H p (10) for chest dosimeters and H p (0.07) for finger dosimeters were reported in a monthly basis. The handling of children during the injection of the dose and the imaging process can be long time processes that can affect the involved personnel regarding dosimetry levels. Results In SPECT/CT examinations the administrated doses range between 0.1 – 20 mCi and in PET/CT 0.9–12 mCi. The exposure of personnel to radiation is increased due to the handling of examined children during: the administration of the dose, where children proved to be ‘difficult’ to handle patients and during the actual imaging process, where children react due to claustrophobia, pain, clinical condition, psychological status, etc. risking to jeopardize imaging data. During the procedure, each staff member is involved in different – specific stages: physicists and some technologists measuring and preparing doses, medical doctors as well as nurse to locate vein and administer the prescribed dose and finally, technologists, nurse and medical doctors handling children during the imaging stage. Therefore, personal depth dose equivalent H p was varied. Although, all measured annual doses are well within national limits, recorded relatively high doses of personnel involved in a specific step of the chain procedure would flag the need for consideration of further radioprotection measures. Conclusions Nuclear medicine examinations in children population require longer exposure time periods to radiation either during the dose injection or during the imaging process. Relatively high doses that correspond to specific procedures indicate that further radioprotection measures need to be considered and applied.

Cyanocyclas brasiliana (Bivalvia: Cyrenidae) rediscovered in the limnic part of Parnaíba River delta, Northeast Brazil

Cyanocyclas brasiliana (Deshayes, 1854) known only from the original very short description and reported from Pará state was recently rediscovered. This is the first occurrence of a native species of Cyrenidae (formerly Corbiculidae) in the Northeast Region of Brazil. Due to a lack of previous data C. brasiliana was initially confused with Corbicula largillierti (Philippi, 1844), an invasive species of Asian origin, which was introduced in South America in the 1970s and already recorded from the North and Northeast regions of Brazil. Ecological aspects are described. To aid identification, type material was studied.

The significance of northern-central Bass Strait in south-eastern Australia as habitat for burrowing seabirds

The present study provides the first complete estimate of the abundance and distribution of burrowing seabirds in northern-central Bass Strait, a key region for breeding seabirds in south-eastern Australia. The estimated total number of breeding burrows in the region in 2008–11 were 755 300 ± 32 400 (s.e.) burrows of Short-tailed Shearwaters (Ardenna tenuirostris), 26 700 ± 3500 of Little Penguins (Eudyptula minor), 19 100 ± 2200 of Common Diving-Petrels (Pelecanoides urinatrix) and 4200 ± 2700 of Fairy Prions (Pachyptila turtur). These represent substantial proportions of the total estimated Australian breeding populations of these species: 6% of the total population of Short-tailed Shearwaters, 14% of Little Penguins, 0.4% of Fairy Prions and 13% of Common Diving-Petrels. Based on the number of active burrows, the number of breeding Short-tailed Shearwaters in the region is estimated to have decreased 35% between 1978–80 and 2008–11, equivalent to a decrease of 1.4% per annum between 1980 and 2011. The regional population of Little Penguins, however, appears to have increased substantially over the same period. Identification of population trends of the other species is limited by a lack of previous data. The importance of this area for burrowing seabirds and the substantial decline in numbers of Short-tailed Shearwaters warrants more frequent monitoring of the abundance of seabirds in the region to allow a robust comparison of changes in populations over time as well as the identification of possible causative factors.

Particle sources over the Danube River delta, Black Sea based on distribution, composition and size using optics, imaging and bulk analyses

Optical measurements provide substantial information on the dynamics and composition of particulate matter in the open ocean and coastal waters. When calibrated with the analysis of simultaneously collected discrete bottle samples, (particulate matter concentration: PMC, particulate organic carbon concentration: POC, chlorophyll α concentration: chl α, particle volume concentration and particle size distribution measured in situ), optical proxies increase the vertical resolution of changes in particle properties in the water column. We report relationships of inherent optical properties (beam attenuation at 2 wavelengths, fluorescence) and bulk particle properties obtained in the NW Black Sea during October 2007. The Danube River delta area was heavily stratified at that time, mainly due to a sharp thermocline at 17–27m. Beam cp and fluorescence were significantly correlated and showed highest values near the coast, with a decreasing trend offshore. In situ measured particle size distributions were characterized by modes at ~40μm, 20μm and 5μm. PMC, POC, and chl α exhibited wide ranges of spatial variation, a common feature being the gradual decrease in concentrations from the coast to offshore. The POC:PMC and POC:chl α ratios suggested a general predominance of biogenic material over terrigenous particles throughout the study area. The commonly accepted sequence of large phytoplanktonic species transitioning to smaller ones during summer–autumn was confirmed by light microscopy and SEM observations. Detritus of Chaetoceros sp. and other diatoms was the dominant component of particulate matter. The small percentage of terrigenous particles was surprising given the high riverine sediment loads suggesting that most of the sediment load flocculated and was deposited before reaching the delta. Given the lack of previous data in this area, our study may serve as a baseline or background to look for changes in future bio-optical and/or biogeochemical measurements.

Effects of lisuride hydrogen maleate on pericontusional tissue metabolism, brain edema formation, and contusion volume development after experimental traumatic brain injury in rats

After traumatic brain injury (TBI), the primary insult is followed by a cascade of secondary events which lead to enlargement of the primary lesion and are potentially amenable to therapeutic intervention. Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic properties. In lack of previous data on lisuride in TBI, and based on well documented changes of dopamine metabolism after TBI, we speculated that lisuride could provide neuroprotection in the acute and post-acute stage of controlled cortical impact (CCI) injury in rats. The effect of varying dosages of lisuride on physiological parameter was investigated. Cerebral microdialysis (CMD) was employed to provide a temporal profile of lactate, pyruvate, glucose and glutamate in the pericontusional brain tissue. Additionally, brain edema formation and the development of contusion volume were assessed. In this study, no effect of treatment was seen on physiological parameters or microdialysis profiling of tissue metabolites. Whereas posttraumatic increase in brain water content and an increase in contusion volume could be observed, there was no significant effect of treatment. Taken together, our results suggest that lisuride does not provide neuroprotection in the CCI model at the acute and subacute stages. Based on the available literature, however, it might be possible that dopamine agonists such as lisuride, respectively, improve outcome in terms of cognitive function in a chronic setting.

Widely Used Pesticides with Previously Unknown Endocrine Activity Revealed as in Vitro Antiandrogens

BackgroundEvidence suggests that there is widespread decline in male reproductive health and that antiandrogenic pollutants may play a significant role. There is also a clear disparity between pesticide exposure and data on endocrine disruption, with most of the published literature focused on pesticides that are no longer registered for use in developed countries.ObjectiveWe used estimated human exposure data to select pesticides to test for antiandrogenic activity, focusing on highest use pesticides.MethodsWe used European databases to select 134 candidate pesticides based on highest exposure, followed by a filtering step according to known or predicted receptor-mediated antiandrogenic potency, based on a previously published quantitative structure–activity relationship (QSAR) model. In total, 37 pesticides were tested for in vitro androgen receptor (AR) antagonism. Of these, 14 were previously reported to be AR antagonists (“active”), 4 were predicted AR antagonists using the QSAR, 6 were predicted to not be AR antagonists (“inactive”), and 13 had unknown activity, which were “out of domain” and therefore could not be classified with the QSAR (“unknown”).ResultsAll 14 pesticides with previous evidence of AR antagonism were confirmed as antiandrogenic in our assay, and 9 previously untested pesticides were identified as antiandrogenic (dimethomorph, fenhexamid, quinoxyfen, cyprodinil, λ-cyhalothrin, pyrimethanil, fludioxonil, azinphos-methyl, pirimiphos-methyl). In addition, we classified 7 compounds as androgenic.ConclusionsDue to estimated antiandrogenic potency, current use, estimated exposure, and lack of previous data, we strongly recommend that dimethomorph, fludioxonil, fenhexamid, imazalil, ortho-phenylphenol, and pirimiphos-methyl be tested for antiandrogenic effects in vivo. The lack of human biomonitoring data for environmentally relevant pesticides presents a barrier to current risk assessment of pesticides on humans.

Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: initial studies and future directions.

Elevated whole blood serotonin 5-HT, or hyperserotonemia, is a common biomarker in autism spectrum disorder (ASD). The integrin β3 receptor subunit gene (ITGB3) is a quantitative trait locus for whole blood 5-HT levels. Recent work shows that integrin β3 interacts with the serotonin transporter (SERT) in both platelets and in the midbrain. Furthermore, multiple studies have now reported gene-gene interaction between the integrin β3 and SERT genes in association with ASD. Given the lack of previous data on the impact of integrin β3 on brain or behavioral phenotypes, we sought to compare mice with decreased or absent expression of the integrin β3 receptor subunit (Itgb3 +/- and -/-) with wildtype littermate controls in behavioral tasks relevant to ASD. These mice did not show deficits in activity level in the open field or anxiety-like behavior on the elevated plus maze, two potential confounds in the evaluation of mouse social behavior. In the three-chamber social test, mice lacking integrin β3 were shown to have normal sociability but did not show a preference for social novelty. Importantly, the absence of integrin β3 did not impair olfaction or the ability to recall familiar social odors. Additionally, mice lacking integrin β3 showed increased grooming behavior in novel environments. These preliminary studies reveal altered social and repetitive behavior in these mice, which suggests that the integrin β3 subunit may be involved in brain systems relevant to ASD. Further work is needed to fully characterize these behavioral changes and the underlying brain mechanisms.

Monitoring biomarkers in fish ( Lepidorhombus boscii and Callionymus lyra) from the northern Iberian shelf after the Prestige oil spill

Hepatic biomarker responses were measured in two demersal fish species ( Lepidorhombus boscii and Callionymus lyra) from the northern Iberian shelf associated with the massive Prestige oil spill (POS), five months after the accident. The biomarkers selected were 7-ethoxyresorufin- O-deethylase (EROD), glutathione- S-transferase (GST), glutathione reductase (GR), catalase (CAT), and DNA integrity. Interspecies differences and spatial variations in biomarker responses were observed along the shelf. GST, GR and CAT activities were significantly elevated in L. boscii in the most oil impacted area (Finisterre) and positively correlated ( p < 0.05) with POS tar aggregate densities. The lack of previous data from the area together with the existence of chronic background pollution of the shelf implies that the observed biomarker responses cannot be solely attributed to the petroleum hydrocarbon components of the spilled oil. This first biological effect assessment showed that L. boscii is a potentially suitable target species to be used in future biomonitoring programmes along the northern Iberian shelf.

Systematic designs for field experimentation with multipurpose trees

Systematic field layouts are especially useful with MPT species for examining plant responses e.g. to density stress, and where a wide range of treatment levels are needed because of lack of previous data. Examples of a ‘fan’ and a ‘parallel-row’ layout are given (with suitable sets of dimensions) and the development of parallel-row designs for management trials and mixed cropping is illustrated.