Problem setting. The transition to an innovative model of economic development of the country is impossible without creating conditions for safe, high-quality, efficient work with decent pay in various sectors of the economy, which contributes to the realization of human potential. The development of the latter is decisive for the further fate of the economic, political, social, spiritual spheres of life in Ukraine and the creation of conditions for its transition to an innovative model of the state system. The implementation of the Concept of Decent Work at all levels is a complex mechanism for solving the accumulated problems in the social and labor sphere of the country. Today, this is especially true of the scientific field related to intellectual activity. Target of research. Research of problematic issues of legal regulation of relations in the scientific sphere on decent working conditions for scientists and identification of ways to solve them. Analysis of recent researches and publications. The issue of decent work in Ukraine is to some extent covered in the scientific works of such scientists as LP Amelicheva, AV Vasylyk, L. Yu. Velychko, OO Gerasimenko, OD Gostyuk, O V. Zhadan, VV Zhernakov, Yu. Ivchuk, AM Kolot, TA Kolyada, SG Rudakova and others. At the same time, to date, there are no relevant comprehensive studies in the available scientific literature to ensure decent work of such subjects of labor law as scientists, as well as the legal mechanism for appropriate provision. Article’s main body. According to the Concept of the State Target Program for the Development of Research Infrastructures in Ukraine for the period up to 2026, approved by the order of the Cabinet of Ministers of Ukraine of April 14, 2021 № 322-r. One of the problems that needs to be solved is the unsatisfactory condition of the material and technical base of research infrastructures, the lack of decent working conditions for scientists and comfortable premises for their work. The scientific potential of human resources in Ukraine is high enough for research. At the same time, with the low level of material and technical base of scientific institutions and higher education institutions, the number of researchers in Ukraine has almost halved in recent years. The most active, creative scientists continue to leave the scientific sphere. Although scientific personnel and knowledge are fundamental factors in the sustainable development of scientific and technical potential of the state. Conclusions and prospects for the development. It is noted that the existence of the problems considered in the article is due not only to insufficient funding for science, although, of course, the economic factor is one of the main, but also imperfect legislation, lack of research infrastructure, lack of career opportunities, weak interaction with business, lack of government policies aimed at supporting the promotion of science and a number of other factors, which leads to the fact that scientists are forced to either go abroad to work or leave science altogether. The expediency of developing a strategy and program to overcome the problems of decent work in the scientific field is indicated. In particular, it is proposed to develop and approve the Concept of implementation of criteria of decent work in the scientific sphere, which will promote the formation of an ideological “human-centric prism”, through which all processes to improve what is happening today. Its main tasks should be: to determine the most important principles and strategic directions of the legal mechanism for ensuring decent work of Ukrainian scientists; improving the legislation in terms of creating and ensuring the functioning of the legal mechanism to ensure decent work of scientists in Ukraine; prevention of negative socioeconomic consequences related to the functioning of the legal mechanism for ensuring decent work of Ukrainian scientists.