Lack Of Aggregation Research Articles

Lack of platelet response to stimulation in the Wiskott-Aldrich syndrome.

Two striking abnormalities were found in the platelets from three boys with the Wiskott-Aldrich syndrome and their mother: lack of aggregation with epinephrine, and lack of metabolic response to stimulation with polystyrene-latex particles and with epinephrine. Whereas normal platelets reacted with an increase of eight to 12 times in citric acid cycle activity to the addition of polystyrene-latex particles, and with an increase of two to three times to epinephrine stimulation, these metabolic reactions were practically absent in the platelets from the affected children and severely depressed also in the platelets of the mother.