The removal of dissolved volatile organic compounds (VOCs) from low-permeability lenses is important to limit back diffusion at sites impacted by dense non-aqueous phase liquids (DNAPLs). In situ thermal treatment (ISTT) technologies have the potential to treat DNAPL-impacted sites by enhancing diffusion from low-permeability lenses during heating. A series of two-dimensional laboratory tank experiments was conducted to investigate heating, gas formation, and trichloroethene (TCE) removal from a clay lens surrounded by sand. Results showed preferential heating of the clay and substantial TCE removal, with post-heating relative concentrations less than 0.06. The extent of TCE removal was not explained by only an increase in the aqueous TCE diffusion coefficient with increased temperature. Modelling estimates based on 1D diffusion from the lens showed that diffusion through both gas and water phases was required to match observations. Gas formation in the interior of the lens was also indicated by measured changes in bulk electrical conductivity of the clay during cool down, with gas saturations estimated to be greater than 0.21 at the end of heating. These estimates were larger than those needed to match the observed removal by diffusion, and suggest that connected gas pathways were created in the lens during heating, but that not all of the gas produced was part of those pathways. These results suggest that ISTT technologies may be effective in removing dissolved VOCs from thin clay lenses, and that gas formation within the clay should be considered when predicting the extent and rate of removal.