The industrial safety of health and medical workers who struggling on the front lines of diseases and disasters to protect public health and life, is threatened by working environment hazard factors that damage health. Despite they are exposing to hazard factors and accumulating mental well-being risks frequently, the social discussions and national efforts for their health were insufficient due to complacent perceptions that “They would be safe from occupational diseases and industrial accidents because of the working environment characteristic that set as medical work”. Korean society needs to enhance the importance of industrial safety because if the mental well-being risk of health and medical workers is not healed in proper time, the deterioration of work engagement can harm personal health and patient life and threat public health and cause a national crisis. Therefore, this study analyzed occupational safety hazard factors that hinder health and medical worker's mental well-being focusing on doctor, nurse, medical technician based on Rutter's ‘Cumulated Risk Model’ that explaining the more accumulate of exposure to simultaneous risk factors, the greater ripple effect of human's internalization and externalization problem. The multiple regression analysis were performed with SPSS Statistics 29.0 for 749 health and medical workers who attended the 6th Korean Working Conditions Survey published by the Korea Occupational Safety and Health Research. As a result, the health and medical worker's mental well-being were hindered whey they exposure to occupational safety hazard factors, emotional labor and quantitative labor intensity were finally verified as occupational safety hazard factors that threatened the mental well-being of them. Based on the results, this study suggested ① services and policies to effectively counter occupational safety hazard factors that hinder the health and medical worker's mental well-being, ② prevention and solution plan about exposure problem to occupational safety hazard factors, ③ customized strategies to promote health and medical workers' mental well-being.