Objective — to establish the role of the nervous system disorders in the formation of irritable bowel syndrome (IBS) among students. Materials and methods. Examination involved 32 students with IBS, aged 19 to 26 years. The Gastrointestinal Quality of Life Index (GIQLI) questionnaire was used, in which 36 questions were presented. Results. The changes in the psycho-emotional sphere in students with IBS occurred in all patients. Upper and lower dyspeptic syndromes with different frequency were inherent in all patients and depended on the nature of the stool. A short-term deterioration of the condition showed after passing tests or exam, which was manifested by increased and upset stools, increased abdominal pain. The skin redness or pallor of the face, excessive sweating, palpitations and fluctuations in blood pressure also were marked. The involvement of the autonomic nervous system with the predominance of the tone of its parasympathetic division has been established. Along with this, the IBS clinical symptoms significantly decreased until the complete disappearance at the peak of the examination period. This phenomenon reflected the formation of a stable psycho-emotional dominant «successful completion of the session». Conclusions. The development of irritable bowel syndrome in a student environment occurs against the background of changes in the autonomic nervous system, which had a significant effect on specific clinical symptoms. Clinical manifestations of IBS in students are reduced in the «peak period» of emotional stress, but are greatly enhanced after «training stresses». In this case, the development of vegetative disorders with acceleration of the heart rate and the lability of blood pressure are traced. The imbalance of the autonomic nervous system not only exacerbates the clinical symptoms of IBS, but also affects the patient quality of life.