Labial Salivary Gland Biopsy Research Articles

DIAGNOSTIC VALUE OF LIP BIOPSY IN SJOGREN'S DISEASE

The diagnostic value of labial salivary gland biopsies has been assessed in the literature since the first report by Meskin and others. Many investigators reported that the histopathology of minor salivary gland of patients with Sjogren's disease might be well correlated with that of other major salivary gland.

Histochemical study of labial salivary glands in Sjögren's syndrome.

Human labial salivary gland biopsies of patients presenting connective tissue diseases associated with Sjögren's syndrome were submitted to a polysaccharide histochemistry study. The normal acinar secretion is an association of neutral polysaccharides with a sulphosialomucin. In Sjögren's syndrome, there is a great reduction in the secretory activity of the acinar cells, but no qualitative change was observed. The pathogenesis of this decreased production and its importance regarding the clinical manifestations of Sjögren's syndrome are discussed.

Necrotizing sialometaplasia of the palate: Ulcerative or necrotizing stage of leukokeratosis nicotina palati?

A typical case of the recently described tumor-suspect lesion, necrotizing sialometaplasia (NS) of the palate, in a 54-year-old Caucasian male is presented. Results of complete blood- and urinanalysis including serum electrophoresis and labial salivary gland biopsy strongly pointed at a local etiologic factor. Previous statements that the disease represents a new entity are questioned. The present authors favor the idea that NS is the necrotizing (ulcerative) or terminal stage of leukokeratosis nicotina palati (nicotinic stomatitis). It is of particular importance that this lesion is not diagnosed as a malignancy, as it heals spontaneously and uneventfully.

Beta2 microglobulin and lymphocytic infiltration in Sjögren's syndrome.

We measured salivary beta2 microglobulin concentrations in 49 patients evaluated for Sjögren's syndrome with a labial salivary-gland biopsy. The salivary concentration was elevated and a significant correlation (P less than 0.001) was found between the concentration and the degree of inflammation seen in the biopsy. Serum concentrations were increased in 135 patients with Sjögren's syndrome. Striking elevations were seen in patients with associated renal or lymphoproliferative complications. Three patients have an increase in serum beta2 microglobulin concentration in association with exacerbation of their disease, and six a decrease after clinically efficacious therapy. These data indicate that determination of beta2 microglobulin in saiva may provide a simple, noninvasive technic for estimation of the degree of local inflammation in autoimmune disease.

The histopathology of Sjögren's syndrome in labial salivary gland biopsies

Labial salivary gland biopsy specimens from seventy-five patients evaluated for Sjögren's syndrome were examined histologically. Clinically severe cases of Sjögren's syndrome showed the most marked histologic change. Focus score was found to be the most useful histologic index of severity of the disease. Large numbers of plasma cells were found in small foci and mild cases. Plasma cells were decreased in proportion, compared to lymphocytes, in larger foci and severe cases. These observations are discussed in the light of possible mechanisms of tissue damage in this disease.

Minor salivary gland involvement in Sjögren's syndrome

This article presents a histologic evaluation of ninety-six minor labial salivary gland biopsies performed at the Clinical Center of the National Institutes of Health from patients with a suspected diagnosis of Sjögren's syndrome. A proposed system of grading, utilizing a 1+ to 4+ scale, is offered on the basis of histologic criteria.

Concentration of iodide, pertechnetate thiocyanate, and bromide in saliva from parotid, submandibular, and minor salivary glands in man.

Abstract Parotid, submandibular, and labial saliva was collected following administration of a mixture containing 132 I − , 99m Tc − , 35 SCN − , and 82 Br − . A biopsy of the labial salivary glands was also obtained from some patients. In all secretions the ions were concentrated in the order I − > SCN − > TcO 4 − ⩾ Br − The concentration gradient for I − was higher in mucous labial saliva than in serous parotid and mixed submandibular saliva, whereas the TcO 4 − , SCN − , and Br − concentration gradients were higher in parotid than in submandibular saliva and not significantly different in parotid and labial saliva. The I − , TcO 4 − , and SCN − concentration gradients in parotid saliva correlated with the corresponding gradients in submandibular saliva and the concentration gradients for TcO 4 − and SCN − correlated with that for I − in the 3 secretions. The I−TcO4− ratio was higher in labial saliva (2.6) than in submandibular saliva (2.0) and parotid saliva (1.8), and did not change with salivary flow rate. Comparable results were obtained for the I−SCN− ratio. The order was the same for the I−Br− ratio, but this ratio varied with salivary flow rate. The concentration gradient of I − , TcO 4 − , and SCN − was inhibited by perchlorate more in parotid than in labial saliva.

Labial salivary gland biopsy in Sjögren's disease

A labial biopsy technique is described and was used to study 40 patients with connective tissue disease and 60 postmortem subjects. More than one focus of lymphocytes per 4 sq mm of minor salivary tissue was found to be a consistent finding in patients with Sjögren's disease. The labial biopsy is shown to be a further valuable investigative procedure in such patients.