Laboratory Measurements Research Articles

Thyroglobulin and calcitonin measurements: pitfalls and future perspectives.

Thyroid cancer is the most prevalent endocrine cancer. Prognosis depends on type and stage of cancer when discovered. Treatment involves (hemi-)thyroidectomy, possibly followed by additional therapeutic options. After treatment, patients are monitored using serum concentrations of endocrine tumour marker thyroglobulin in case of differentiated cancer and calcitonin in case of medullary thyroid cancer. Measuring thyroglobulin and calcitonin concentrations in serum may be challenging. In this review we give a complete overview of the evolvement in laboratory measurements regarding thyroglobulin and calcitonin with an emphasis on (pre-)analytical challenges and potential approaches to overcome current pitfalls.

Adaptively remeshed multiphysical modeling of resistance forge welding with experimental validation of residual stress fields and measurement processes

Welding processes used in the production of pressure vessels impart residual stresses in the manufactured component. Computational modeling is critical to predicting these residual stress fields and understanding how they interact with notches and flaws to impact pressure vessel durability. In this work, we present a finite element model for a resistance forge weld and validate it using laboratory measurements. Extensive microstructural changes, near-melt temperatures, and large localized deformations along the weld interface pose significant challenges to Lagrangian finite element modeling. The proposed modeling approach overcomes these roadblocks in order to provide a high-fidelity simulation that can predict the residual stress state in the manufactured pressure vessel; a rich microstructural constitutive model accounts for material recrystallization dynamics, a frictional-to-tied contact model is coordinated with the constitutive model to represent interfacial bonding, and adaptive remeshing is employed to alleviate severe mesh distortion. An interrupted-weld approach is applied to the simulation to facilitate comparison to displacement measures. Several approaches are employed for residual stress measurement in order to validate the finite element model: neutron diffraction, the contour method, and the slitting method. Model-measurement comparisons are supplemented with detailed simulations that reflect the configurations of the residual-stress measurement processes themselves. The model results show general agreement with experimental measurements, and we observe some similarities in the features around the weld region. Factors that contribute to model-measurement differences are identified. Finally, we conclude with some discussion of the model development and residual stress measurement strategies, including how to best leverage the efforts put forth here for other types of related weld problems.

Structural and hydrodynamic modelling of the probability of breakage of branching and plate coral colonies

Climate change is amplifying the intensity of severe weather events, with coastal regions such as coral reefs facing heightened vulnerability to cyclonic wave forces. Structural models to predict bending stress and breakage of corals have been developed for coral colonies to enhance comprehension and prediction of the effects of hydrodynamic disturbances on coral reefs. However, there is scope for improving these predictions by evolving the methodology for quantifying complicated and variable coral morphologies. This study aims to predict breakage thresholds for two of the most prevalent coral morphologies: branching and plate corals (using Acropora muricata and Acropora hyacinthus as study species). Laboratory and field measurements were taken to assess coral morphologies and material characteristics. Morphological features of 47 branching colonies and 100 plate colonies were surveyed at the study site (Heron Reef, southern GBR) and the tensile strength of 80 coral samples was obtained by in situ and laboratory testing. Three-dimensional structural models of branching and plate coral colonies were developed, encompassing multiple coral colonies with varying morphological patterns from relatively shallow (5-7 m) to deep (9-12 m) zones. Model results were calibrated and verified with existing data, revealing that velocity thresholds of 1.7 m/s and 5.0 m/s would destroy 90% of the simulated branching coral structures growing in the deep and shallow parts of the forereef zone, respectively. In contrast, the plate corals have sufficient margins of safety even in extreme flow conditions (7 m/s). Additionally, skeletal strength and structural performance were adjusted based on varying degrees of bioerosion inside the coral skeleton. A higher probability of breakage was observed as the extent of bioerosion increased. The laboratory experiments of hydrodynamic loads on coral colony show that the sheltering effect due to one or two neighbouring colonies in the upwave direction is negligible. These models can be easily adjusted to provide predictions for other coral species, shapes, levels of bioerosion, and locations (e.g., sheltered or exposed areas). Comprehensive predictions about the level of expected damage and rubble generation in different areas can be used in reef management planning and restoration prioritization.

Acoustic scattering by smooth and rough elastic cylinders insonified by directional sonars: Bistatic experiments.

Bistatic laboratory measurements are presented for acoustic scattering from both smooth and rough elastic cylinders insonified by directional spherical waves. A scattering model, accounting for incident directional spherical waves while assuming negligible end effects, was derived in a previous article [Mursaline, Stanton, Lavery, and Fischell, J. Acoust. Soc. Am. 154, 307-322 (2023)] but only evaluated for monostatic scattering by smooth cylinders. The evaluation is extended here to bistatic geometries for both smooth and rough cylinders. The effect of axi-symmetric Gaussian roughness (axi-symmetric random variations in cylinder radius) on the cylinder on overall scattering levels and resonances is investigated. Particular emphasis is given to the influence of roughness on the excitation of axially propagating guided wave resonances associated with oblique incident angles. Bistatic laboratory observations presented herein further substantiate the effects on scattering due to the properties of the incident field from practical sonars, such as spherical spreading, as observed in the above-mentioned article. For smooth cylinders, axially propagating guided wave resonances are seen to become more prominent during bistatic in-plane scattering compared to bistatic orthogonal-plane scattering and previously published monostatic data. For rough cylinders, both overall scattering levels and resonances are found to be diminished compared to the smooth case.

Experimental study of thermoconcentration convection in air–water and air–undecane mixtures

A quantitative experimental comparison was conducted between thermal convection in dry air and thermoconcentration convection in two gas mixtures: air–water vapor and air–undecane vapor, within the temperature range of 0–80 °C at normal atmospheric pressure. Convection in these mixtures is driven by temperature and concentration gradients of water (or undecane) vapor in the air. The stationary thermoconcentration convection is accompanied by continuous phase transitions of the fluids. The quantitative results of the experiments are represented in terms of the Nusselt number Nu and the effective Rayleigh number RaE, which is the sum of the thermal RaT and concentration RaC Rayleigh numbers. Quantitative laboratory measurements were performed using the thermocouple method and were supplemented with qualitative data from visual monitoring of transparent fluid flows using holographic interferometry. The cubic and quadratic temperature dependencies of RaCRaT−1 were determined experimentally for moist air and for the air–undecane vapor mixture, respectively. The significant role of moisture phase transitions in air convection is established. Neglecting these effects at 25 °C and using the ordinary RaT instead of actual RaE would result in an error exceeding 30%. At 38 °C, this error would increase to nearly 100%. At around 80 °C, thermoconcentration convection becomes almost entirely concentration-driven, as the high molecular disordered thermal motion is suppressed by the ordered convective motion generated by evaporation and condensation of water on the opposite heat exchangers of the convective cell.

Experimental Study Of Anisotropic And Dispersion Signature Of Shale Reservoirs: Implications For Synthetic Seismic Well Tie

To investigate velocity anisotropy and dispersion in lacustrine shales, we conducted laboratory measurements of acoustic properties at seismic frequencies (2–100 Hz) and ultrasonic frequencies (1 MHz) under varying effective pressures. Our study reveals significant transverse isotropy, accompanied by notable velocity dispersion and attenuation, with anisotropy coefficients ranging from 0.45 to 0.74 for P-waves and 0.44 to 0.95 for S-waves. Attenuation exhibited weak dependence on frequency and pressure but showed a strong positive correlation with clay content. We interpreted the data by integrating geological and physical analyses. Using rock physics modeling and the propagation matrix method, we found that velocity dispersion primarily caused the mismatch between seismic data and synthetic seismograms, while anisotropy had minimal impact on near-offset seismic data. Our findings suggest that anisotropy and dispersion observed at the core scale persist at the seismic scale. Incorporating these effects into seismic workflows is crucial for improving data processing, inversion, and reservoir characterization. This study provides valuable insights for exploration and production strategies in the study area and similar settings.

Enhancing Oil Recovery in Eagle Ford Shale: A Multiscale Simulation Study of Surfactant Huff ’n’ Puff Methodology

In this paper, we present a simulation case study of a surfactant huff ’n’ puff pilot in the black oil window of the Eagle Ford (EF) Shale. The target horizontal well, which had been depleted for nearly 8 years, underwent stimulation via a surfactant huff ’n’ puff treatment. The surfactant was selected through laboratory screening using reservoir rock and fluid samples. After a 17-hour injection and a 1-month shut-in period, the well’s production increased fivefold from the baseline oil rate, sustaining incremental oil production for at least 2 years. The surfactant enhances oil recovery by altering rock wettability toward a more water-wet state and moderating oil/water interfacial tension (IFT). This process is modeled by surfactant adsorption in the simulator, indicating the degree of dynamic changes in relative permeability (krl) and capillary pressure (Pc) curves. We propose a comprehensive workflow comprising three stages: development of core-scale and field-scale models, sequential model calibrations, and multiobjective optimization to integrate laboratory measurements and field data from this pilot into multiscale numerical simulations. By matching oil recoveries from imbibition experiments on the core model and field production histories on the field model, krl and Pc profiles of two extreme states, basic reservoir properties, and additional reservoir properties altered during huff ’n’ puff operations are characterized. The matched core model reproduces a 15.1% incremental oil recovery for surfactant-assisted spontaneous imbibition (SASI) process relative to pure brine imbibition process. The matched reservoir model predicts the surfactant huff ’n’ puff treatment increases the oil production by 21.9% relative to water huff ’n’ puff treatment and by 52.9% relative to primary depletion for a 4-year period. The calibrated reservoir model also serves as a base case for optimizing well operation schedules through the implementation of a multiobjective genetic algorithm. The surfactant injection rate, injection time, and well shut-in time of the base case are varied to achieve higher oil production and reduced surfactant usage. Statistical analysis of eight trade-off cases indicates that optimal well operations, compared with existing practices, frequently involve increased injection rates [16.6–18.9 barrels per minute (bpm)], shorter injection periods (10–11.3 hours), and prolonged shut-indurations (49–65 days). This workflow offers valuable insights into surfactant huff ’n’ puff treatments for unconventional reservoirs, thereby facilitating the optimization of well operations and maximizing tertiary oil recovery.

Design and application of a shipborne underwater radiation detector array for the monitoring of seawater radioactivity

A navigable online monitoring system for marine radioactivity was developed to cope with possible large-scale marine nuclear pollution incidents. This system used a NaI(Tl) detector array mounted on a ship to collect radioactive data across wide marine areas rapidly. High volume-efficiency aids the system in rapidly identifying radionuclides exceeding standard levels. This feature enables the system to monitor the seawater in a wide area within a shorter time and promptly detect marine nuclear pollution incidents. Monte Carlo simulations were used to optimize the number of NaI(Tl) crystals and the detector spacing for enhancing the volume-efficiency of the system. Three Φ3" × 6″ NaI(Tl) detectors and the mounting bracket with a fixed detector spacing of 30 cm were fabricated based on the simulation outcomes. The volume-efficiency for 137Cs of the system was around six times higher than that for the buoy-based monitoring system with a 3-inch NaI(Tl) detector. The theoretical volume-efficiency curve, which was calculated through Monte Carlo simulation, was verified in a standard liquid source. The minimum detectable activity concentration (MDC) for radioisotopes of the system under various radioactive measurement durations was discussed, such as the MDC for 137Cs for 5 min measurement was 0.152 Bq/L. Marine radioactivity measurement experiments were conducted in the sea near the Tianwan nuclear power plant in Lianyungang, China. The test results showed that the activity concentration of 40K was 11.4 Bq/L. The results of navigation monitoring were consistent with those of sampling and laboratory measurement, which verified the stability and accuracy of the system.

Mobile laboratory measurements of air pollutants in Baltimore, MD elucidate issues of environmental justice

ABSTRACT The City of Baltimore, MD has a history of problems with environmental justice (EJ), air pollution, and the urban heat island (UHI) effect. Current chemical transport models lack the resolution to simulate concentrations on the scale needed, about 100 m, to identify the neighborhoods with anomalously high air pollution levels. In this paper we introduce the capabilities of a mobile laboratory and an initial survey of several pollutants in Baltimore to identify which communities are exposed to disproportionate concentrations of air pollution and to which species. High concentrations of black carbon (BC) stood out at some locations – near major highways, downtown, and in the Curtis Bay neighborhood of Baltimore. Results from the mobile lab are confirmed with longer-term, low-cost monitoring. In Curtis Bay, higher concentrations of BC were measured along Pennington Ave. (mean [5th to 95th percentiles] = 2.08 [2.0–10.9] μg m−3) than along Curtis Ave. just ~ 150 m away (0.67[0.1 – 1.8] μg m−3). Other species, including criteria pollutants ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and fine particulate matter (PM2.5), showed little gradient. Observations with high spatial and temporal resolution help isolate the mechanisms leading to locally high pollutant concentrations. The difference in BC appears to result not from heavier truck traffic or slower dispersion but from the interruptions in traffic flow. Pennington Ave. has three stoplights while Curtis Ave. has none. As heavy-duty diesel-powered vehicles accelerate, they experience turbo-lag and the resulting rich air-fuel mixture exacerbates BC emissions. Immediate mediation might be achieved through smoother traffic flow, and the long-term solution through replacing heavy-duty trucks with electric vehicles. Implications: We present results documenting the locations within Baltimore of high concentrations of Black Carbon pollution and identify the likely source – diesel exhaust emissions exacerbated by stop-and-go traffic and associated turbo-lag. This suggests solutions (smoother traffic, retrofit particulate filters, replacement of diesel with electric vehicles) that would enhance Environmental Justice (EJ) and could be applied to other cities with EJ problems. Synopsis: This paper presents observations of atmospheric black carbon aerosol showing impacts on environmental justice, then identifies causes and suggests solutions.

Analytic solutions for effective elastic moduli of isotropic solids containing oblate spheroid pores with critical porosity

AbstractAccurate characterization for effective elastic moduli of porous solids is crucial for better understanding their mechanical behaviour and wave propagation, which has found many applications in the fields of engineering, rock physics and exploration geophysics. We choose the spheroids with different aspect ratios to describe the various pore geometries in porous solids. The approximate equations for compressibility and shear compliance of spheroid pores and differential effective medium theory constrained by critical porosity are used to derive the asymptotic solutions for effective elastic moduli of the solids containing randomly oriented spheroids. The critical porosity in the new asymptotic solutions can be flexibly adjusted according to the elastic moduli – porosity relation of a real solid, thus extending the application of classic David‐Zimmerman model because it simply assumes the critical porosity is one. The asymptotic solutions are valid for the solids containing crack‐like oblate spheroids with aspect ratio < 0.3, nearly spherical pores (0.7 < < 1.3) and needle‐like prolate pores with > 3, instead of just valid in the limiting cases, for example perfectly spherical pores (= 1) and infinite thin cracks (0). The modelling results also show that the accuracies of asymptotic solutions are weakly affected by the critical porosity and grain Poisson's ratio , although the elastic moduli have appreciable dependency of and . We then use the approximate equations for pore compressibility and shear compliance as inputs into the Mori–Tanaka and Kuster–Toksoz theories and compare their calculations to our results from differential effective medium theory. By comparing the published laboratory measurements with modelled results, we validate our asymptotic solutions for effective elastic moduli.

Measurement of emerging neurocognitive and language skills in the HEALthy Brain and Child Development (HBCD) study

The HEALthy Brain and Child Development (HBCD) study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The study plans enrolling over 7000 families across 27 sites. This manuscript presents the measures from the Neurocognition and Language Workgroup. Constructs were selected for their importance in normative development, evidence for altered trajectories associated with environmental influences, and predictive validity for child outcomes. Evaluation of measures considered psychometric properties, brevity, and developmental and cultural appropriateness. Both performance measures and caregiver report were used wherever possible. A balance of norm-referenced global measures of development (e.g., Bayley Scales of Infant Development-4) and more specific laboratory measures (e.g., deferred imitation) are included in the HBCD study battery. Domains of assessment include sensory processing, visual-spatial reasoning, expressive and receptive language, executive function, memory, numeracy, adaptive behavior, and neuromotor. Strategies for staff training and quality control procedures, as well as anticipated measures to be added as the cohort ages, are reviewed. The HBCD study presents a unique opportunity to examine early brain and neurodevelopment in young children through a lens that accounts for prenatal exposures, health and socio-economic disparities.

Soft sensor for melting flow rate prediction based on data-enhanced classification method

Abstract The melt flow rate (MFR) is a crucial quality indicator for polyolefin products. However, the offline laboratory measurement method suffers from significant time delays between sampling and obtaining test values, making it inconvenient for real-time product quality control. Additionally, installing an online analyzer can be expensive. In this study, we propose a soft sensor method that combines mechanism analysis and data-driven approaches to predict the MFR in the extruder process. Firstly, we analyze the physical mechanism of the extruder process, and the time series data are processed into independent enhanced data sets by reasonably selecting data enhancement parameters. Secondly, we statistically model the distribution of particle MFR and classify the data into four sections. We train Deep Neural Network (DNN) and Gradient Boosting Decision Tree (GBDT) regression models separately for low and non-low MFR sections while also developing a global classification model to invoke corresponding regression models when needed. The results demonstrate that our classification model achieves 100% accuracy in distinguishing between low and non-low MFR categories; furthermore, our regression models achieve an RMSE of 0.600, and an R2 value of 0.998, outperforming existing models on various indicators. Finally, considering viscosity variations in polyolefin products' influence on prediction performance, we recommend setting data enhancement parameters contrary to particle MFR trends.

Reconciling remote-sensing estimates of Ryugu’s albedo with laboratory measurements

Reconciling remote-sensing estimates of Ryugu’s albedo with laboratory measurements

Applied experimental research on in-situ online monitoring instrument for soil radon in fault zone

As an emerging method for seismic precursory signals in underground fluid, the reliability and stability of in-situ online monitoring devices for soil radon are crucial performance indicators that are directly related to the successful implementation of continuous monitoring of soil radon in seismic areas. This study conducted laboratory testing and field applications of a new in-situ online monitoring instrument for seismic soil radon, utilizing the experimental testing conditions provided by the radon monitoring instrument detection platform of the China Earthquake Administration and the natural experimental site at Xianshuihe Fault Zone in the China Seismic Experimental Site. The results indicate that laboratory measurement repeatability of the instrument is 5.53%, the relative intrinsic error of radon volume response activity is 1.53%, and the response capability of hourly sampling at high radon volume response activity (greater than 1.0 × 105 Bq/m3) lags behind the standard instrument by 2 h, essentially meeting the requirements for seismic observation. Under field conditions, the instruments exhibit good synchronization in response at different depths at the same location. However, further improvements are needed to enhance the consistency of long-term operation in the field, as well as the adaptability to outdoor self-powering, data transmission, and environmental conditions.

In-situ water retention monitoring system of an operational dike

The severe droughts in recent decades and the lack of regular flooding have caused considerable fissures to develop on clay embankments. Previous surveys in Hungary have identified the examined dike section as prone to desiccation cracks. It is essential to determine the possible extent of these desiccation cracks, as they degrade the dikes’ resistance against several failure mechanisms. A representative dike cross-section was equipped with a unique water retention monitoring system comprising 17 sensors, including 14 soil moisture and 3 water potential sensors. These devices were validated with laboratory measurements to obtain accurate results. The gravimetric water content (w) ranged from 8.3 % to 31.3 %, and the matric potential was recorded between 0.1 kPa and 2350.7 kPa over one and a half years. The study examined the differences in soil behaviour under pavement and turf cover, identifying common moisture content distribution patterns and areas of the cross-section prone to desiccation cracking. The uniqueness of the monitoring system lies in the fact that it was established in an operational embankment, which regulates the flow of a river. Furthermore, it was instrumented along the Tisza River, which is among Europe’s most significant watercourses. The results may help better understand the moisture content change in clay embankments and the role of the crest pavement in the moisture content distribution.

Proteogenomic analysis integrated with electronic health records data reveals disease-associated variants in Black Americans.

Most genome wide association studies (GWAS) of plasma proteomics have focused on White individuals of European ancestry, limiting biological insight from other ancestry enriched protein quantitative loci (pQTL). We conducted a discovery GWAS of ~3,000 plasma proteins measured by the antibody based Olink platform in 1,054 Black adults from the Jackson Heart Study (JHS), and validated our findings in the Multi-Ethnic Study of Atherosclerosis (MESA). The genetic architecture of identified pQTLs were further explored through fine mapping and admixture association analysis. Finally, using our pQTL findings, we performed a phenome wide association study (PheWAS) across two large multi-ethnic electronic health record (EHR) systems in All of Us and BioMe. We identified 1002 pQTLs for 925 proteins. Fine mapping and admixture analyses suggested allelic heterogeneity of the plasma proteome across diverse populations. We identified associations for variants enriched in African ancestry, many in diseases that lack precise biomarkers, including cis-pQTLs for Cathepsin L (CTSL) and Siglec-9 that were linked with sarcoidosis and non-Hodgkin's lymphoma, respectively. We found concordant associations across clinical diagnoses and laboratory measurements, elucidating disease pathways, including a cis-pQTL associated with circulating CD58, white blood cell count, and multiple sclerosis. Our findings emphasize the value of leveraging diverse populations to enhance biological insights from proteomics GWAS, and we have made this resource readily available as an interactive web portal.

The impact of group cognitive behavioral psychotherapy on disease severity and psychosocial functioning in patients with inflammatory bowel disease: a randomized controlled study.

Patients with inflammatory bowel disease (IBD) often report symptoms of anxiety and depression as well as impaired quality of life (QoL). To date, there are few studies on the effect of psychotherapy on psychological functioning and clinical outcome in patients with IBD. The aim of this prospective, randomized, controlled study was to investigate the effect of a brief psychotherapeutic intervention on psychological distress, QoL, sexual functioning, and inflammation and disease activity indices in patients with IBD. Participants were randomized to receive either group cognitive behavioral therapy or treatment as usual (controls) and were assessed at baseline and after six months using psychometric instruments to assess psychological distress, QoL, and sexual functioning. In addition, laboratory measurements, including levels of C-reactive protein (CRP), cytokines and calprotectin, and calculations of disease activity indices were performed during the two study periods. 80 participants took part in the study. Patients who received psychotherapy reported a significant decrease in anxiety and depression symptoms, a significant improvement in physical functioning, general health, vitality, social functioning and mental health, a decrease in physical pain and a decrease in role limitations caused by emotional problems. CRP levels and the Crohn's disease activity index (CDAI) also decreased significantly at follow-up compared to controls. Group cognitive behavioral therapy is proving to be an important component of holistic care for IBD patients, as it can significantly improve not only patients' psychosocial functioning but also their clinical course by inhibiting inflammation and reducing disease activity.

Updated System of S i Levels Using Fourier Transform Infrared Spectroscopy in the Range from 800 to 11,000 cm−1

In this study we report on high-precision laboratory measurements of transition wavenumbers for 172 atomic sulfur lines in the infrared region 800–11,000 cm−1 using Fourier transform spectroscopy techniques. Our analysis includes 96 lines that have not been previously measured in the laboratory. We also correct several sulfur energy-level measurements reported in earlier studies. These refined measurements are important for a range of scientific disciplines, such as astrophysics, atmospheric chemistry, and combustion plasma physics. We have used the combined list of all observed lines to derive a refined set of sulfur energy levels. For about half of all nonautoionizing levels, the uncertainties have been reduced by a factor between 2 and 23. From the newly measured nonpenetrating (high-l) Rydberg levels we have also obtained the first ionization energy of the S atom, IE = 83,559.170(11) cm−1, which is more accurate than the currently recommended value by 2 orders of magnitude. Our analysis has led to a significantly more accurate result than the earlier set of Ritz wavelengths with observed intensities reduced to a common uniform scale and an extended list of recommended transition probabilities.

Feasibility of Metrological Traceability Implementation Using the Joint Committee on Traceability in Laboratory Medicine Database Entries Including the Fulfillment of "Fit-for-Purpose" Maximum Allowable Measurement Uncertainty.

In previous publications, the Task Force on Reference Measurement System Implementation proposed a procedural approach combining a critical review of entries available in the Joint Committee on Traceability in Laboratory Medicine (JCTLM) database with a comparison of this information against analytical performance specifications for measurement uncertainty (MU) and applied it to a group of 13 measurands. Here we applied this approach to 17 additional measurands, of which measurements are frequently requested. The aims of the study were (a) to describe the main characteristics for implementing traceability and the potential to fulfill the maximum allowable MU (MAU) at the clinical sample level of certified reference materials and reference measurement procedures listed in the JCTLM database; (b) to discuss limitations and obstacles, if any, to the achievement of the required quality of laboratory measurements; and (c) to provide a gap analysis by highlighting what is still missing in the database. Results were integrated with those obtained in the previous study, therefore offering an overview of where we are and what is still missing in the practical application of the metrological traceability concept to 30 common biochemical tests employed in laboratory medicine. Our analysis shows that for 28 out of 30 measurands, conditions exist to correctly implement metrological traceability to the International System of units and fulfill at least the MAU of the minimum quality level derived according to internationally recommended models. For 2 measurands (serum albumin and chloride), further improvements in MU of higher-order references would be necessary.

The Influence of a Lubricant Medium on the Development of Fretting Wear in an Interference Fit Connection

Fretting wear is a phenomenon occurring in many engineering objects, including push fit connections. In view of a large number of factors conducive to wear development, it is difficult to describe the mechanism of wear initiation and development. Therefore, various methods are sought to limit wear development. The use of a lubricant may be one of those ways. The aim of this article is to present the results of testing the influence of a lubricant medium on the development of fretting wear in interference fit connections. As a lubricant medium, MoS2 and Whitmore greases were used. For that purpose, wear tests were first conducted on the shaft/sleeve tribological kinematic pair, and then observations and laboratory measurements were performed. The observations demonstrated the presence of fretting wear traces on all tested samples, irrespective of the tribological kinematic pair being tested. The main kind of damage consisted of material build-ups which, during operation, become oxidised and, while moving along the connection, caused local abrasion and micropits. The best results in restricting the development of fretting wear were achieved with Whitmore grease.