PASTEUR INSTITUTEPARIS-- Just days into his term as the new director-general of the illustrious Pasteur Institute, Philippe Kourilsky spelled out plans for big changes in a meeting here last week with the research center's nearly 1100 scientists. His strategy includes a stronger concentration on public health and applied research as well as a stiffer evaluation process that some Pasteur researchers say could lead to a major reshuffling of lab heads in coming years. Yet despite this potential shake-up, Pasteurians who spoke with Science are casting their lot with their new boss.