Abstract A series of LaxCuy/TiO2 catalysts were prepared by sol-gel method to remove HCN under the conditions of 1% O2 and 10% relative humidity. Samples were characterized by BET, XRD, XPS, H2-TPR, NH3/CO2-TPD and FT-IR. NH3-SCR reactions were carried out to verify the results of the catalyst activity tests and explore N2 formation mechanism. La/Cu ratios had a prominent impact on the catalyst performance. La1Cu9/TiO2 had the best catalytic activity: its conversion of HCN and N2 selectivity were 100% and 62.24% at 150 °C, respectively. The characterization results indicated interactions between La and Cu, catalytic redox activity and existence of abundant acidic and basic sites on the catalyst surface. Low content of La significantly improved catalytic redox ability and total acidity as well bring about the catalyst medium strong acid sites with a lower temperature. Synergistic effects of La and Cu oxides provided La1Cu9/TiO2 catalysts with remarkable activity at low temperatures.