Spicules of sponges and sclerites of chancelloriids have been collected from in situ Cambrian sections of the La Laja Formation (San Juan Precordillera). They have also been collected from carbonate olistoliths, which were emplaced from the Cambrian units in the Early Ordovician Los Sombreros Formation (San Juan Precordillera) and Empozada Formation (Mendoza Precordillera). The Cambrian La Laja Formation sequences were deposited in a shallow carbonate platform in the eastern part of the Precordillera. The Cambrian carbonate rocks, which make up the olistoliths in the Los Sombreros and Empozada Formations, record deposition in the slope environments which developed in the western Precordillera. Cambrian Porifera and sponge-like chancelloriid assemblages are known mainly from fragments of skeletal nets, dissociated spicules and sclerites, which enable us to define two assemblages. The first assemblage of spicules was defined from the upper Lower to Middle Cambrian sequences of the La Laja Formation. This assemblage consists of a variety of stauractines and sclerites of Chancelloria WALCOTT. The family Protospongiidae is represented by triradiate prodianes, pentactines and hexactines, all belonging to Kiwetinokia WALCOTT. The second assemblage, which consists of isolated hexactines, pentactines, monaxons and skeletal nets, was defined in the Cambrian derived olistholiths of the Los Sombreros and Empozada Formations. Early hexactinellid Protospongiidae with body preservation (Diagoniella ? and Kiwetinokia) also occur. Demosponges have a very limited record in the Cambrian of the Precordillera. Anthaspidellid sponges had been reported from the La Laja Formation and now from the San Martin olistolith (Empozada Formation). The occurrences of these two assemblages of spicules and sclerites in both the Cambrian platform and slope facies of the Precordillera contribute additional data for a better understanding of the relationships between the eastern and the western facies assemblages, which developed in the Precordillera during the Cambrian. Therefore, they are useful for paleoenvironmental and paleogeographical interpretations of the Cambrian depositional framework.