Kwandong University College Research Articles

Content Analysis of Reflective Journals in Early Clinical Experience

This study qualitatively analyzed medical students’ engagement of pre-clerkship early clinical experience and their implications based on reflective journals. The subjects were 60 third-year students who had taken the early clinical experience course offered by the Catholic Kwandong University College of Medicine. Students had to complete and submit a reflective journal at the end of the course. This study used the reflective journals students submitted as analysis data. Data were analyzed using Elo and Kyngäs’ inductive qualitative analysis. As a result of study, a total of 127 unique significant keywords and statements were extracted. These statements generated 11 formulated sub-categories and five theme categories. Five main categories were derived from the students’ reflective journals: understanding of patients, understanding of professionalism, understanding of other occupations, understanding of the hospital system, and motivation to learn. Students understood patients’ perspectives on diseases and improved their ability to empathize; they gained confidence in communication and clinical skills; they became more positive toward the underprivileged; and their interest in the medical system grew. The results suggest that early clinical experience can be applied as one beneficial educational program for medical students in the pre-clerkship curriculum.

Influence of Diazepam on Video Head Impulse Test in Patients with Acute Vestibular Neuritis: Preliminary Study

Received June 9, 2015 Revised August 28, 2015 Accepted August 30, 2015 Address for correspondence Minbum Kim, MD Department of OtorhinologyHead and Neck Surgery, Catholic Kwandong University College of Medicine, 25 Simgok-ro 100beon-gil, Seo-gu, Incheon 22711, Korea Tel +82-32-290-3978 Fax +82-32-290-3050 E-mail minbumkim78@gmail.com Background and ObjectivesZZAlthough video head impulse test (V-HIT) has emerged as a popular test for vestibular function, there have been no reports about the influence of benzodiazepine on the test. The aim of this study is to investigate the influence of diazepam on the V-HIT in patients with acute vestibular neuritis. Subjects and MethodZZWe retrospectively analyzed charts and medical records of 10 patients diagnosed with acute vestibular neuritis. The patients repeated V-HIT before and after intravenous (IV) injection of diazepam. Gain and presence of catch-up saccade (CUS) were compared. ResultsZZGain in the affected ear was decreased compared to that in the unaffected ear. After the injection of IV diazepam, the presence of CUS was not changed significantly. Gain of CUS in V-HIT was also unchanged both in the affected and unaffected ear after the injection of IV diazepam. ConclusionZZThe influence of IV diazepam on the gain and presence of CUS in V-HIT were insignificant, indicating that it could be considered as a useful test to evaluate vestibular function in patients treated with diazepam. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(1):15-8

A Case of Horizontal Partial Laryngectomy for Laryngeal Trauma

Received August 11, 2013 Revised October 31, 2013 Accepted October 31, 2013 Address for correspondence Hyun Jun Hong, MD, PhD Department of OtorhinolaryngologyHead and Neck Surgery, Catholic Kwandong University College of Medicine, International St. Mary’s Hospital, 25 Simgok-ro 100beon-gil, Seo-gu, Incheon 404-834, Korea Tel +82-32-290-3051 Fax +82-32-290-3050 E-mail hyunjun.hong@gmail.com *Current affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Catholic Kwandong University College of Medicine, International St. Mary’s Hospital, Incheon, Korea Laryngeal trauma is rare compared to other head and neck traumas, but it occurs, it can be life threatening. As for treatment, a laryngeal fracture that involves displacement of cartilage or extensive injury requires appropriate surgical treatments. For severe laryngeal fractures, conservative management is usually preferred with placing a stent to prevent laryngeal stenosis. But the downside of placing stents in the larynx includes the risk of granulation and infection. In this report, the authors describe a 35-year-old patient, who was diagnosed with blunt laryngeal trauma and treated by Horizontal partial laryngectomy. The patient’s post-operative breathing and voice were fair, and airway stenosis did not occur afterwards. Korean J Otorhinolaryngol-Head Neck Surg 2015;58(2):120-3

Contamination of the Hospital Environmental by Pathogenic Bacteria and Infection Control

Contamination of the Hospital Environmental by Pathogenic Bacteria and Infection Control Young Ah Kim, Hyukmin Lee, Kyungwon Lee Department of Laboratory Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Department of Laboratory Medicine, Catholic Kwandong University College of Medicine, Incheon, Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea

The TRAIL Sensitization Effect of Substituted Triazolyl Curcumin Mimics Against Brain Cancer Cells

Department of Microbiology, Catholic Kwandong University College of Medicine, Gangneung 210-701, Korea Department of Basic Science, Catholic Kwandong University College of Medicine, Gangneung 210-701, Korea Department of Pharmacology, Wonkwang University School of Medicine, Iksan 570-749, Korea. *E-mail: stress@wku.ac.kr Department of Pharmacology, Catholic Kwandong University College of Medicine, Gangneung 210-701, Korea *E-mail: sjlee@cku.ac.kr Received June 13, 2014, Accepted July 9, 2014

Cytotoxicity of Substituted Benzimidazolyl Curcumin Mimics Against Multi-Drug Resistance Cancer Cell

Cell Therapy and Tissue Engineering Center, Yonsei University Wonju College of Medicine, Wonju 220-701, Korea Department of Basic Science, Kwandong University College of Medicine, Gangneung 210-701, Korea Department of Basic Science, Yonsei University Wonju College of Medicine, Wonju 220-701, Korea E-mail: ahn0707@yonsei.ac.kr Marine Chemomics Laboratory, Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Korea Department of Pharmacology, Kwandong University College of Medicine, Gangneung 210-701, Korea E-mail: sjlee@kwandong.ac.kr Received December 26, 2012, Accepted January 21, 2013

A Successful Delivery of a Woman with Pulmonary Arterial Hypertension: Under Close Observation and without Medications

Received: 2013.9.8, Revised: 2013.9.12, Accepted: 2013.9.12 Correspondence to: Hyun Ho Shin, MD Address: Department of Internal Medicine, Cheil General Hospital & Women’s Healthcare Center, Kwandong University College of Medicine, 17 Seoae-ro 1-gil, Jung-gu, Seoul 100-380, Korea Tel: +82-2-2000-7245, Fax: +82-2-2000-7895 E-mail: hho.shin@cgh.co.kr because of pulmonary hypertensive crises, pulmonary thrombosis, or refractory right heart failure. The risk probably increases with more elevated pulmonary pressures. However, even moderate forms of pulmonary vascular disease can worsen during pregnancy as a result of the decrease in systemic vascular resistance and overload of the right ventricle, and no safe cut-off value is known. If pregnancy occurs, termination used to be offered. Therefore, it is important to discuss effective methods of birth control with women with PAH of child-bearing potential, although the preferred method is not clear. Hwang et al. and Min et al. reported successful deliveries of pulmonary hypertension while using ❙Case Report❙ Vol. 19, No. 3, September 2013 ISSN 2233-8136, eISSN 2233-8454, http://dx.doi.org/10.5646/jksh.2013.19.3.90 Copyright 2013. The Korean Society of Hypertension c A Successful Delivery of a Woman with Pulmonary Arterial Hypertension: Under Close Observation and without Medications

Risk Factors for Treatment Failure in Benign Paroxysmal Positional Vertigo

Received October 30, 2012 Revised December 21, 2012 Accepted December 21, 2012 Address for correspondence Dae Bo Shim, MD Department of Otorhinolaryngology, Myongji Hospital, Kwandong University College of Medicine, 697-24 Hwajeong-dong, Deogyang-gu, Goyang 412-270, Korea Tel +82-31-810-5407 Fax +82-31-969-0500 E-mail lovend77@gmail.com Background and ObjectivesZZParticular repositioning maneuver (PRM) have been recommended as a treatment of benign paroxysmal positional vertigo (BPPV). Some patients require multiple treatments for remission, although most of the patients are treated at the first trial of single maneuver. The purpose of this study was to evaluate risk factors for the treatment failure in patients with posterior canal BPPV (p-BPPV) and horizontal canal BPPV (h-BPPV). Subjects and MethodZZRetrospective review was performed for the 287 patients diagnosed as BPPV visiting the dizziness clinic between February 2011 and August 2012. The diagnostic criteria for BPPV were met by following the guidelines provided by the American Academy of Otolaryngology-Head and Neck Surgery. Patients were classified into two groups: Group 1 (treatment success) that requires only 1 PRM and Group 2 (treatment failure) that requires more than 2 PRMs. We analyzed the relationship between treatment failure and the clinical characteristics, and studied the etiology of BPPV. ResultsZZThe study included 183 patients with p-BPPV, 54 patients with h-BPPV (geotropic type), and 50 patients with h-BPPV (apogeotropic type). The type of BPPV and average numbers of PRM required for remission were significantly related with treatment failure by statistical analysis (p<0.05, respectively). Statistically significant correlation was demonstrated between the history of ipsilateral inner ear viral infection (acute vestibular neuritis, sudden sensorineural hearing loss) and treatment failure (p<0.05). ConclusionZZMultiple PRMs may be required in patients with h-BPPV (apogeotropic type) or with secondary BPPV caused by ipsilateral inner ear viral disease. Clinically, this information may be used to provide helpful information for clinicians performing PRM to treat BPPV. Korean J Otorhinolaryngol-Head Neck Surg 2013;56:74-8

Structural Analysis of Proximal Humerus in Korean

Structural Analysis of Proximal Humerus in Korean Jeong Hyun Yoo, M.D.*, Soo Tai Chung, M.D. , Byung Chae Jo, M.D.*, Jae Won Hyung, M.D., and Doo Jin Bak, M.D. Department of Orthopedic Surgery, Kwandong University College of Medicine, Gangneung, *Department of Orthopedic Surgery, Myongji Hospital, Goyang, Department of Orthopedic Surgery, Public Health & Medical Care Center, Yeoncheon, Department of Anatomy, Hanyang University College of Medicine, Seoul, Korea

영유아 신경발달평가의 임상 적용

Department of Psychiatry, Myongji Hospital, Kwandong University College of Medicine, Goyang, KoreaEarly detection and intervention is critical in improving prognosis of developmental disorders. Developmental delay can have many different causes and the clinical features of developmental delay are diverse according to its etiologic causes and severity. The vast and rapid growth of the child’s neurobehavioral repertoire from birth through adolescence requires the physician’s abun-dant experience, knowledge, and understanding of development. Here, we summarize instruments for use in neurodevelopmental assessment of infants and toddlers, focusing on motor development, which is the most frequent complaint listed in the develop-mental clinic.

Fetal Loss Rate after Mid-trimester Amniocentesis

Fetal loss rate after mid-trimester amniocentesis You Jung Han, Yun Young Kim, Si Won Lee, Min Hyung Kim, Jin Hoon Chung, Hyun Kyong Ahn, Jung Yeol Han, Moon Young Kim, Jae Hyug Yang, So Yeon Park, Hyun Mee Ryu Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, Korea; Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea

Usefulness of Impulse Oscillometry In Children With Eosinophilic Bronchitis

FEBRUARY 2012 AB4 Abstracts S A T U R D A Y 13 Usefulness of Impulse Oscillometry In Children With Eosinophilic Bronchitis Y. Kim, K. Kim, J. Baek, H. Park, H. Lee, M. Sohn, K. Kim; Department of Pediatrics and Institute of Allergy, Severance Biomedical Science Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, REPUBLIC OF KOREA, Kwandong University College of Medicine, Goyang, REPUBLIC OF KOREA. RATIONALE: Eosinophilic bronchitis (EB) has been shown to resolve, whereas it has been shown to progress to asthma in some patients, despite treatment with inhaled steroids. It is controversial whether EB is a pre-form of asthma.We evaluated pulmonary function by impulse oscillometry (IOS) and airway inflammation by measuring fractional exhaled nitric oxide (FeNO) of children with EB in comparison of those with asthma and healthy children as a control. METHODS: A total of 232 children with asthma, 109 with EB, and 115 control subjects were enrolled. We compared pulmonary function test parameters and FeNO levels among three subject groups, and designated a cutoff value of FeNO combined with IOS parameters to distinguish EB from the control group. RESULTS: Pulmonary function and bronchodilator response for EB in spirometry were of normal range as well as for the control. In IOS, the percentage change in reactance at 5 Hz (D X5) and the percentage change in reactance area (DAX) of the EB as well as the asthma groups decreased significantly compared to the control (P < .0001). A cutoff value to distinguish EB from control was D X5 is220% (sensitivity, 77.5%; specificity, 49.6%), and D AX is 230% (sensitivity, 75.0%; specificity, 46.0%) when FeNO is 20 ppb. CONCLUSIONS: Reversible airway obstruction in IOS and elevated FeNO levels can be useful for evaluation of EB in children. This would support that EB shows airway characteristics similar to those of asthma.

Double Dislocation of Interphalangeal Joints in a Single Digit - A Case Report -

Received: October 11, 2012 Revised: December 6, 2012 Accepted: December 6, 2012 Correspondence to: Jeong Hyun Yoo Department of Orthopaedic Surgery, Myongji Hospital, Kwandong University College of Medicine, 55 Hwasu-ro 14beon-gil, Deokyang-gu, Goyang 412-826, Korea TEL: +82-31-810-6530 FAX: +82-31-810-6900 E-mail: yjh89331@yahoo.co.kr Double dislocation of the interphalangeal joints in a single digit is very rare. We describe the results of conservative treatment for the double interphalangeal dislocations of 5th finger caused by hyperextension during bicycle accident.

Pregnancy outcomes after exposure to phendimetrazine in first trimester of pregnancy

목적 펜디메트라진은 암페타민과 유사한 작용을 일으키는 교감신경 흥분제로 식욕억제 효과가 있어 체중감량을 목적으로 쓰인다. 임신초기 펜디메트라진을 복용 시 태아의 선천성 기형과 관련이 있다는 연구 결과들이 있다. 몇몇의 연구에서 구순구개열, 선천성 횡격막탈장의 위험성이 증가한다는 보고가 있다. 본 연구에서는 임신 초기 펜디메트라진을 복용한 임신부를 대상으로 펜디메트라진의 복용과 태아기형과의 관련성을 알아보고자 하였다. 연구방법 임신초기 펜디메트라진에 노출된 62명의 임신부 코호트를 대상으로 분만 시까지 추적 관찰하였고, 나이 및 임신력을 대조하여 펜디메트라진에 노출되지 않은 122명의 임신부를 대조군으로 설정하였다. 출생 시 소아과 의사가 태아의 주요 기형 유무를 검사하였다. 결과 펜디메트라진에 노출된 임신부의 평균 나이는 33.2±4.9세이며 임신력은 2.2±1.1였으며 노출 평균 주수는 4.2±2.0주였다. 모든 임신은 초음파로 확인하였다. 약물에 노출된 임신부 중 자연유산 3명(1.0%)를 제외한 26명을 조사하였고 이 중 2명에서 각각 맥락막 낭종, 내반족을 가진 태아이상 소견이 있었다. 대조군에서는 11명의 태아이상 소견이 있었으며 두 군 사이에 태아 비정상 소견 발생에 대한 통계학적인 차이는 없었다(7.7% vs. 12.0%; P=0.54; odds ratio, 0.61; 95% confidence interval, 0.12 to 2.96). 결론 임신 초기 펜디메트라진의 복용이 태아 정상발육 위험성을 증가시키지 않았다.

The analysis of factors which affect resection margin status after conization for cervical intraepithelial neoplasia

목적 자궁경부 원추절제술 후 절제 변연부 침범 소견을 보일 때 병변의 중증도가 이에 미치는 영향에 대하여 살펴보고 절제 변연부 침범과 재발 및 잔류종양의 연관성에 대하여 알아보고자 하였다. 연구방법 2003년 11월부터 2011년 2월까지 자궁경부 원추절제술을 시행 받은 후 cervical intraepithelial neoplasia (CIN)으로 진단된 환자 202명을 대상으로 후향적 연구를 시행하였다. 원추절제술 후 환자는 자궁절제술을 시행 받거나 3-6개월 간격으로 자궁경부세포검사를 통한 추적관찰을 시행하였으며 이상 소견을 보이는 경우 질확대경하에 조직검사를 시행하였다. 재발은 CIN I 이상의 조직 소견을 보이는 경우로 정의하였다. 결과 CIN으로 진단된 환자 202명 중 CIN I은 46명(22.8%), CIN II는 35명(17.3%), CIN III는121명(59.9%)이었다. 절제 변연부 침범 소견을 보인 환자는 67명(33.2%)이었고 CIN I은 7명(10.4%), CIN II는 14명(20.9%), CIN III는 46명(68.7%)으로 CIN의 중증도가 심할수록 절제 변연부의 침범 빈도가 증가하였다(P = 0.009). 자궁절제술을 시행 받은 환자는 28명(13.9%)으로 절제 변연부 침범이 없었던 환자는 13명, 절제 변연부 침범이 있었던 환자는 15명이었고 각각 7명(53.8%)과 5명(33.3%)에서 잔류 병변이 존재하여 절제 변연부의 침범 여부와 잔류종양의 유무는 통계학적으로 유의한 상관관계를 보이지 않았다(P = 0.445). 보존적 치료를 시행한 환자는 174명으로 이 중 절제 변연부 침범을 보인 3명(3/52, 5.7%)과 절제 변연부 침범을 보이지 않은 2명(2/122, 1.6%)의 환자에서만 재발을 보였다(P = 0.335). 결론 CIN 환자에 있어 병변의 중등도가 심할수록 절제 변연부 침범이 있을 가능성이 크지만 절제 변연부의 침범이 있다 하더라도 실제적으로 잔류 병변이 없는 경우가 더 많으며 절제 변연부의 침범 여부가 재발과는 유의한 상관관계가 없는 것으로 나타났다. 따라서 변연부 침범소견을 보이는 경우라도 지속적 추적관찰만 잘 이루어 질 수 있다면 CIN의 치료로 충분하다 할 수 있겠다. 또한 절제 변연부의 침범이 없는 경우에도 잔류종양이 남아 있을 가능성이 있으므로 주의 깊은 추적관찰이 필요할 것으로 생각된다.

A History of the Korean Society of Thoracic Radiology

Copyright r 2010 by Lippincott Williams & Wilkins From the *Department of Radiology, Seoul St Mary’s Hospital, The Catholic University of Korea, College of Medicine; wDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul; and zDepartment of Radiology, Myongji Hospital, Kwandong University College of Medicine, Gyeonggi-do, Korea. Reprints: Myeong Im Ahn, MD, Department of Radiology, Seoul St Mary’s Hospital, The Catholic University of Korea, College of Medicine, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea (e-mail: ami@ catholic.ac.kr). HISTORICAL FEATURE

Identification of Bacterial and Fungal Isolates by Sequence Analysis of 16S rRNA and Internal Transcribed Spacer

Department of Laboratory Medicine, Kwandong University College of Medicine, Goyang, Soonchunhyang University College of Medicine, Korea University College of Medicine, Seoul, Department of Clinical Laboratory Science, Dongeui University, Busan, Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Korean Institute of Tuberculosis, Seoul, Korea