A procedure for improving the energy, economic and environmental sustainability of the transformation houses in low-voltage distribution networks is described in this paper. This procedure is based on the reduction of the transformer consumption, copper and core losses. Likewise, the procedure distinguishes between transformation houses with old and new transformers. The reduction of core losses, replacing transformers with others of lower power or that are more efficient, achieves significant improvements in energy and environmental aspects. The reduction of copper losses, and applying reactive compensation techniques, such as harmonic filtering and load balancing, applied in old and new transformation houses, have a greater impact on cost savings, especially when there are capacitive consumptions, as the Circular 3/2020 of the National Markets and Competition Commission of Spain determines. The procedure has been applied to an industrial transformation house, which has an old 1600 kVA transformer, resulting in significant economic savings and CO2 reductions of more than 60%, after replacing the current transformer with a more efficient one.