K-space Weighted Image Contrast Research Articles

Dynamic contrast-enhanced MRI of gastric cancer: Correlation of the perfusion parameters with pathological prognostic factors.

To investigate the feasibility of dynamic, contrast-enhanced, magnetic resonance imaging (DCE-MRI) for perfusion quantification of gastric cancers, and to correlate the DCE-MRI parameters with the pathological prognostic factors. This prospective study was approved by our Institutional Review Board. Twenty-seven patients with gastric cancers underwent DCE-MRI using a free-breathing, radial, gradient-echo (GRE) sequence with k-space weighted image contrast (KWIC) reconstruction on a 3T scanner. The DCE-MRI parameters (volume transfer coefficient [K(trans) ], reverse reflux rate constant [Kep ], extracellular extravascular volume fraction [Ve ], and initial area under the gadolinium concentration curve during the first 60 seconds [iAUC]) of gastric cancer and normal wall were measured and compared with each other using the Wilcoxon signed rank test. The relationship between the DCE-MRI parameters of gastric cancer and the pathological prognostic factors were evaluated using the Mann-Whitney test or the Spearman rank correlation test. DCE-MRIs were of diagnostic quality in 22 patients (81.5%). Ve and iAUC were significantly higher in gastric cancer than in normal gastric wall (P < 0.05). Ve showed significant positive correlation with T-staging of gastric cancers (P < 0.05). K(trans) was significantly correlated with the grades of epidermal growth-factor receptor expression (P < 0.05). DCE-MRI using a radial GRE with KWIC reconstruction is feasible for quantification of the perfusion dynamics of gastric cancers, and the DCE-MRI parameters of gastric cancers may provide prognostic information.

Radial volumetric imaging breath-hold examination (VIBE) with k-space weighted image contrast (KWIC) for dynamic gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI of the liver: advantages over Cartesian VIBE in the arterial phase

To compare radial volumetric imaging breath-hold examination with k-space weighted image contrast reconstruction (r-VIBE-KWIC) to Cartesian VIBE (c-VIBE) in arterial phase dynamic gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (DCE-MRI) of the liver. We reviewed 53 consecutive DCE-MRI studies performed on a 3-T unit using c-VIBE and 53 consecutive cases performed using r-VIBE-KWIC with full-frame image subset (r-VIBEfull) and sub-frame image subsets (r-VIBEsub; temporal resolution, 2.5-3 s). All arterial phase images were scored by two readers on: (1) contrast-enhancement ratio (CER) in the abdominal aorta; (2) scan timing; (3) artefacts; (4) visualisation of the common, right, and left hepatic arteries. Mean abdominal aortic CERs for c-VIBE, r-VIBEfull, and r-VIBEsub were 3.2, 4.3 and 6.5, respectively. There were significant differences between each group (P < 0.0001). The mean score for c-VIBE was significantly lower than that for r-VIBEfull and r-VIBEsub in all factors except for visualisation of the common hepatic artery (P < 0.05). The mean score of all factors except for scan timing for r-VIBEsub was not significantly different from that for r-VIBEfull. Radial VIBE-KWIC provides higher image quality than c-VIBE, and r-VIBEsub features high temporal resolution without image degradation in arterial phase DCE-MRI. Radial VIBE-KWIC minimised artefact and produced high-quality and high-temporal-resolution images. Maximum abdominal aortic enhancement was observed on sub-frame images of r-VIBE-KWIC. Using r-VIBE-KWIC, optimal arterial phase images were obtained in over 90 %. Using r-VIBE-KWIC, visualisation of the hepatic arteries was improved. A two-reader study revealed r-VIBE-KWIC's advantages over Cartesian VIBE.

Associations between tumor vascularization assessed by in vivo DCE‐MRI and the presence of disseminated tumor cells in bone marrow in breast cancer patients at the time of diagnosis

To explore possible associations between in vivo pharmacokinetic dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters and the presence of disseminated tumor cells (DTCs) in bone marrow in breast cancer patients at the time of diagnosis. Thirty-seven women with breast cancer (stage T2-4N0-1M0) were included. Patients were classified as DTC+ if one or more DTCs were detected by immunocytochemistry. DCE-MRI was acquired with a radial 3D T1 -weighted spoiled gradient echo sequence with k-space weighted image contrast. K(trans), kep, and ve were calculated using the extended Tofts model and a population-derived arterial input function. The nonparametric Mann-Whitney U-test was used to compare the histogram distributions of the pharmacokinetic parameters for the DTC+ and the DTC- patients. DTCs were detected in 7 of the 37 patients (19%). In DTC+ patients, the distribution of tumor K(trans) and kep were significantly (P < 0.01) more shifted towards lower values than in DTC- patients. An association between vascular dependent pharmacokinetic DCE-MRI parameters and the presence of DTCs were found. Compared to DTC- patients, DTC+ patients had poorer perfusion and permeability, indicative of hypoxia. Thus, pharmacokinetic parameters might be surrogate biomarkers of metastatic potential and future relapse.

Reducing contrast contamination in radial turbo-spin-echo acquisitions by combining a narrow-band KWIC filter with parallel imaging.

Cartesian turbo spin-echo (TSE) and radial TSE images are usually reconstructed by assembling data containing different contrast information into a single k-space. This approach results in mixed contrast contributions in the images, which may reduce their diagnostic value. The goal of this work is to improve the image contrast from radial TSE acquisitions by reducing the contribution of signals with undesired contrast information. Radial TSE acquisitions allow the reconstruction of multiple images with different T2 contrasts using the k-space weighted image contrast (KWIC) filter. In this work, the image contrast is improved by reducing the band-width of the KWIC filter. Data for the reconstruction of a single image are selected from within a small temporal range around the desired echo time. The resulting dataset is undersampled and, therefore, an iterative parallel imaging algorithm is applied to remove aliasing artifacts. Radial TSE images of the human brain reconstructed with the proposed method show an improved contrast when compared with Cartesian TSE images or radial TSE images with conventional KWIC reconstructions. The proposed method provides multi-contrast images from radial TSE data with contrasts similar to multi spin-echo images. Contaminations from unwanted contrast weightings are strongly reduced.

New imaging strategies using a motion-resistant liver sequence in uncooperative patients.

MR imaging has unique benefits for evaluating the liver because of its high-resolution capability and ability to permit detailed assessment of anatomic lesions. In uncooperative patients, motion artifacts can impair the image quality and lead to the loss of diagnostic information. In this setting, the recent advances in motion-resistant liver MR techniques, including faster imaging protocols (e.g., dual-echo magnetization-prepared rapid-acquisition gradient echo (MP-RAGE), view-sharing technique), the data under-sampling (e.g., gradient recalled echo (GRE) with controlled aliasing in parallel imaging results in higher acceleration (CAIPIRINHA), single-shot echo-train spin-echo (SS-ETSE)), and motion-artifact minimization method (e.g., radial GRE with/without k-space-weighted image contrast (KWIC)), can provide consistent, artifact-free images with adequate image quality and can lead to promising diagnostic performance. Understanding of the different motion-resistant options allows radiologists to adopt the most appropriate technique for their clinical practice and thereby significantly improve patient care.

Noncontrast enhanced four‐dimensional dynamic MRA with golden angle radial acquisition and k‐space weighted image contrast (KWIC) reconstruction

To explore the feasibility of 2D and 3D golden-angle radial acquisition strategies in conjunction with k-space weighted image contrast (KWIC) temporal filtering to achieve noncontrast enhanced dynamic MRA (dMRA) with high spatial resolution, low streaking artifacts and high temporal fidelity. Simulations and in vivo examinations in eight normal volunteers and an arteriovenous malformation patient were carried out. Both 2D and 3D golden angle radial sequences, preceded by spin tagging, were used for dMRA of the brain. The radial dMRA data were temporally filtered using the KWIC strategy and compared with matched standard Cartesian techniques. The 2D and 3D dynamic MRA image series acquired with the proposed radial techniques demonstrated excellent image quality without discernible temporal blurring compared with standard Cartesian based approaches. The image quality of radial dMRA was equivalent to or higher than that of Cartesian dMRA by visual inspection. A reduction factor of up to 10 and 3 in scan time was achieved for 2D and 3D radial dMRA compared with the Cartesian-based counterparts. The proposed 2D and 3D radial dMRA techniques demonstrated image quality comparable or even superior to those obtained with standard Cartesian methods, but within a fraction of the scan time.

Free-breathing dynamic contrast-enhanced MRI of the abdomen and chest using a radial gradient echo sequence with K-space weighted image contrast (KWIC)

To evaluate the feasibility of free-breathing, dynamic contrast-enhanced (DCE) MRI of the abdomen and thorax using the radial-gradient-echo sequence with k-space weighted image contrast (KWIC) reconstruction. Institutional review board approval was obtained. Fourteen patients underwent free-breathing radial DCE-MRI. Radial MRI yielded full-frame images by gridding all k-space data and time-resolved subframe images by using KWIC reconstruction technique. Using subframe KWIC images, voxel-wise perfusion maps were created. For comparison, the breath-hold conventional Cartesian 3D-gradient-echo sequence (VIBE) was also performed during the equilibrium phase. The image qualities of radial and conventional VIBE images were compared quantitatively and qualitatively. Radial DCE-MRI provided high spatial resolution (1.4 × 1.4 mm) and temporal resolution (4.1 s for subframe images) allowing voxel-wise perfusion mapping with negligible motion or streaking artefacts. There were no significant differences in SNR between full-frame radial images and conventional VIBE images (79.08 vs 74.80, P > 0.05). Overall image quality score of full-frame radial images was slightly lower than that of conventional VIBE images (3.88 ± 0.59 vs. 4.31 ± 0.97, P < 0.05), but provided clinically useful images. The free-breathing radial DCE-MRI can provide high spatial and temporal resolution while maintaining reasonably high image quality and thus is a feasible technique for DCE-MRI in the abdomen and thorax. • Dynamic contrast-enhanced magnetic resonance imaging (DCE) MRI is important in oncological imaging • Radial MRI with k-space weighted image contrast (KWIC) reconstruction offers potential improvements • Radial DCE-MRI provides good image quality, reduced artefacts and high spatial/temporal resolution.

Solid Pancreatic Lesions: Characterization by Using Timing Bolus Dynamic Contrast-enhanced MR Imaging Assessment—A Preliminary Study

To assess the feasibility of postprocessing dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging timing bolus data by using a three-dimensional radial gradient-echo technique with k-space-weighted image contrast (KWIC) for the characterization of solid pancreatic diseases. This retrospective study was approved by the institutional review board, and informed consent was waived. A total of 45 patients suspected of having biliary or pancreatic disease underwent pancreatic MR examination with a 3.0-T imager with a low-dose (2 mL gadopentetate dimeglumine) timing bolus by using the radial KWIC technique. There were 24 patients with pancreatic cancers, eight with pancreatic neuroendocrine tumors (PNETs), three with chronic pancreatitis, and 10 with a normal pancreas. By using a dedicated postprocessing software program for DCE MR imaging, the following perfusion parameters were measured for tumor and nontumorous parenchyma: volume transfer coefficient (K(trans)) and extracellular extravascular volume fraction; the rate constant (k(ep)) and initial area under the concentration curve in 60 seconds (iAUC) were then generated. The perfusion parameters acquired on DCE MR images were compared among the groups by using the analysis of variance test. K(trans), k(ep), and iAUC values in patients with pancreatic cancer (0.042 min(-1) ± 0.023 [standard deviation], 0.761 min(-1) ± 0.529, and 2.841 mmol/sec ± 1.811, respectively) were significantly lower than in patients with a normal pancreas (0.387 min(-1) ± 0.176, 6.376 min(-1) ± 2.529, and 7.156 mmol/sec ± 3.414, respectively) (P < .05 for all). In addition, k(ep) values of PNETs and normal pancreas also differed (P < .0001), and K(trans), k(ep), and iAUC values of pancreatic cancers and PNETs differed significantly (P < .0001, P = .038, and P < .0001, respectively). Results of timing bolus DCE MR imaging with the radial KWIC sequence from routine examinations can be postprocessed to yield potentially useful perfusion parameters for the characterization of pancreatic diseases.

Respiratory motion‐compensated radial dynamic contrast‐enhanced (DCE)‐MRI of chest and abdominal lesions

Dynamic contrast-enhanced (DCE)-MRI is becoming an increasingly important tool for evaluating tumor vascularity and assessing the effectiveness of emerging antiangiogenic and antivascular agents. In chest and abdominal regions, however, respiratory motion can seriously degrade the achievable image quality in DCE-MRI studies. The purpose of this work is to develop a respiratory motion-compensated DCE-MRI technique that combines the self-gating properties of radial imaging with the reconstruction flexibility afforded by the golden-angle view-order strategy. Following radial data acquisition, the signal at k-space center is first used to determine the respiratory cycle, and consecutive views during the expiratory phase of each respiratory period (34-55 views, depending on the breathing rate) are grouped into individual segments. Residual intrasegment translation of lesion is subsequently compensated for by an autofocusing technique that optimizes image entropy, while intersegment translation (among different respiratory cycles) is corrected using 3D image correlation. The resulting motion-compensated, undersampled dynamic image series is then processed to reduce image streaking and to enhance the signal-to-noise ratio (SNR) prior to perfusion analysis, using either the k-space-weighted image contrast (KWIC) radial filtering technique or principal component analysis (PCA). The proposed data acquisition scheme also allows for high frame-rate arterial input function (AIF) sampling and free-breathing baseline T(1) mapping. The performance of the proposed radial DCE-MRI technique is evaluated in subjects with lung and liver lesions, and results demonstrate that excellent pixelwise perfusion maps can be obtained with the proposed methodology.

High frame‐rate simultaneous bilateral breast DCE‐MRI

A simultaneous bilateral back-projection method for 3D dynamic contrast-enhanced (DCE)-MRI of the breasts was developed and evaluated. Using a double-side band modulation of the RF slab excitation pulse, discontinuous volumes that included both breasts were simultaneously selected. The number of slice phase-encoding steps was undersampled by a factor of 2, and the resulting signal aliasing from one volume to the other was removed using SENSE processing. In-plane encoding was performed with an interleaved radial acquisition reconstructed using dynamic k-space-weighted image contrast (KWIC) temporal filtering. Image resolution was 0.5 x 0.5 x 3.0 mm(3) with an effective temporal resolution of 15 s for both breast volumes. Combined with the 2x acceleration from SENSE encoding, this is a 16x acceleration factor over a conventional MR bilateral breast scan. An initial evaluation of these methods was performed on a cohort of women who presented with palpable or mammographically visible breast abnormalities. A total of 73 abnormalities were found in 45 of the 54 bilateral examinations that were performed. In 11 of these cases there was a significant finding in the contralateral breast. DCE images of both breasts can be acquired simultaneously, resulting in high-resolution images as well as rapid sampling of the contrast kinetics.

Dynamic MRI with projection reconstruction and KWIC processing for simultaneous high spatial and temporal resolution.

A method for dynamic imaging in MRI is presented that enables the acquisition of a series of images with both high temporal and high spatial resolution. The technique, which is based on the projection reconstruction (PR) imaging scheme, utilizes distinct data acquisition and reconstruction strategies to achieve this simultaneous capability. First, during acquisition, data are collected in multiple undersampled passes, with the view angles interleaved in such a way that those of subsequent passes bisect the views of earlier ones. During reconstruction, these views are weighted according to a previously described k-space weighted image contrast (KWIC) technique that enables the manipulation of image contrast by selective filtering. Unlike conventional undersampled PR methods, the proposed dynamic KWIC technique does not suffer from low image SNR or image degradation due to streaking artifacts. The effectiveness of dynamic KWIC is demonstrated in both simulations and in vivo, high-resolution, contrast-enhanced imaging of breast lesions.