Continuous occurrences of several thousands of earthquakes in Koyna–Warna region since the initial impoundment (1962) of the Koyna reservoir has attracted the attention of seismologists all over the world to know the exact earthquake physical processes involved. The area has been a site for reservoir-triggered earthquakes for the last four and half decades. Major bursts of seismic activity occurred during 1967, 1973, 1980, 1993, and 2000 and recently in 2005 with magnitudes exceeding 5.0 in the region. A notable southward migration of seismicity has been observed following the impoundment of another reservoir, the nearby Warna reservoir. All the mainshocks suggest that the significant southward migration might be due to pore-pressure diffusion. We have divided the entire period from 1967 to 2007 in several sequences starting by a mainshock of M >5. Each sequence is critically analyzed in terms of triggering by the diffusion process through the fractured medium. The pore-fluid diffusion tensor D for each sequence is estimated based on Darcy’s law. The direction of temporal migration of seismicity of each sequence except 1980 is correlated well with the eigenvectors of diffusion. The fluid flow eigenvectors are constrained with one of the strike directions of the focal mechanisms. The frequency magnitude distribution shows the b value to vary from 0.5 to 1.2. Spatial distribution of the b value further indicates that the area along the major faults is more prone to future earthquake.