Objective: This study identified the effects of Korean medicine treatment on a patient with metabolic dysfunction-associated fatty liver disease (MAFLD).Methods: A 43-year-old man with MAFLD was treated with <i>Saenggangunbi-tang</i> with regular exercise from August 13, 2022, to December 24, 2022, to reduce fatigue and dyspepsia and to improve laboratory findings, such as liver enzymes and lipid profiles. We observed changes in symptoms and laboratory findings during the approximately four-month treatment.Results: Treatment with <i>Saenggangunbi-tang</i> resulted in decreased serum levels of liver enzymes, triglycerides, hepatic steatosis index scores, and clinical symptoms. During the treatment, the patient performed regular exercise; however, there was no significant change in body weight until the end of the study.Conclusion: This study suggests the availability of <i>Saenggangunbi-tang</i> as a therapeutic option for managing MAFLD patients.