The determinants of major parasitic infections in women have never been studied systematically. Much work remains to be done before vital gaps in our knowledge will be filled. The protocol presented here categorizes the determinants of parasitic diseases, and functions as an inventory for research needs and priorities. In this paper, the synoptic inventory is tested by matching it against the scientific knowledge of schistosomiasis that is at hand. Available data and existing lacunae are discussed. We conclude that the environmental, economic, socio-cultural, nutritional, genetic, biological and immunological factors which determine schistosomiasis in women are largely unknown. There is an urgent need for systematic and interdisciplinary investigations before appropriate and sustainable interventions can be initiated.