: The study assesses the effect of health education intervention programme on awareness of danger signs in childhood illnesses (Under-Five Children) among caregivers in Kaduna State. Nigeria. To achieve the purpose of the study, five research questions were raised while five hypotheses were formulated and tested to guide the study. Quasi-experimental of pre-test and post-test experimental and control groups was adopted for this study. The population of the study consist of 19,684 of the entire caregivers in Kaduna State. The sample size of this study is two hundred (200) participants selected by using multi-stage sampling techniques. The instrument for data collection for the study is researcher’s developed questionnaire. Inferential statistic of paired sample t-test was used to test the formulated hypotheses at 0.05 level of significance. The finding indicated that there is significance awareness of danger signs in childhood illnesses (Under-Five Children) among caregivers in Kaduna state, Nigeria after health education intervention programme (t-23.07, df: 99; P=.000); and there is significant difference between the experimental and control group after health education intervention programme based on their awareness of danger signs in childhood illnesses (t=-15.316, df: 198; (P=.000). Based on the findings of the study it was concluded that health education intervention programme improves awareness of danger signs in childhood illnesses (Under-Five Children) among caregivers in Kaduna state, Nigeria. This is because the effect of health education intervention programme was significant. It was therefore recommended among others that the Kaduna State Ministry of Health should work with all the healthcare facilities to promote that health education intervention programme on knowledge of danger signs in childhood illnesses and should be carried out during ANC visits.