This study examined the influence of media advocacy on the knowledge of prevention measures and management strategies of early childhood diseases among nursing mothers in Ikwo L.G.A of Ebonyi state. The survey design was adopted in the course of the work. Data for the study was gathered through questionnaire. 850 questionnaires were distributed to the respondents. The frequency tables and percentages and the independent sample tests were used as methods of data analysis. From the analyses conducted, it was revealed that there are prevalent early childhood diseases in Ikwo local government area of Ebonyi state, there are communication intervention programs used in enhancing knowledge of prevention and management of early childhood disease among nursing mothers in Ikwo Local Government Area of Ebonyi state, and communication intervention programs on early childhood disease have not enhanced knowledge of prevention and management strategies among nursing mothers in Ikwo Local Government Area of Ebonyi state. It is the recommendation of the study that that there should be an increase in early child disease awareness among individuals, family and communities by ensuring community participation in the control and much research should be carried out to find out better ways to ensure communication intervention programs on early childhood disease enhances knowledge of prevention and management strategies among nursing mothers.