losers—it focuses on exchange and builds on the respective strengths of institutions and countries. Importantly, it recognizes that benefits will differ among partners and countries. In our highly interdependent world, higher education facilitates the cross-border flow and the exchange of people, knowledge, values, innovation, economy, technology, and culture. But why is it framed in a “power paradigm” like soft power? Are the values of self-interest, competition, or dominance going to effectively address issues of worldwide epidemics, terrorism, failed states, the bottom billion in poverty and climate change? The answer is no. This is based on the reality that solutions to worldwide challenges cannot be achieved by one country alone. An alternative to the power paradigm is the framework of diplomacy. Diplomacy, interpreted as the management of international relations, focuses on negotiation, mediation, collaboration, compromise, and facilitation. These are different tactics and concepts than those attached to power dominance, authority, command, and control. Is knowledge diplomacy more appropriate to frame the role of higher education in international relations, than the soft power paradigm? Knowledge is a cornerstone of today’s interconnected world. The evolution from the new information and communication technologies of cyberspace, to the big data of infospace, to the knowledge processing of knowspace brings new opportunities and complexities to international higher education. However, there is no denying that knowledge can also lead to power imbalances within and among countries. This reality is exacerbated when higher education and knowledge are seen as tools of soft power. The alternative of using collaboration and mediation strategies of diplomacy requires serious consideration. International higher education has the opportunity of moving beyond its preoccupation, with the knowledge economy, and takes a proactive role to ensure that knowledge is effectively used to address worldwide challenges and inequalities, by recognizing the mutuality of interests and benefits. Is higher education ready to take a lead in promoting the notion of knowledge diplomacy and not remain stuck, in the soft power frame of self-interest and dominance? Sustaining Quality and Massification: Is It Possible?