Orthopedic surgeons must be proficient with many arthroscopic procedures. At the most basic level, consistent and secure tissue repair with arthroscopic knots is an essential skill. This skill can be mastered by following basic principles, practice, and attention to detail. There are special instruments to aid the surgeon in knot tying, knot tensioning, and suture cutting. A variety of suture material and knot designs is available and should be chosen to match the specific situation at hand. We do not intend to provide step-by-step instructions for tying every knot that has been described in the literature. Our goal is to provide a comprehensive overview of the arthroscopic knot-tying technique and the equipment available to today’s orthopedic surgeon. Knowledge of fundamentals will enable the surgeon to choose the appropriate suture material and knot construct, but practice is required to actually perform the task and know which instruments function best in their hands.