Background. Cervical cancer (CC) is the fourth most common cancers affecting women. It being preventable, a robust and effective national education cum screening program is the key to curb its increasing incidence. Objectives. This cross-sectional study was designed to investigate the knowledge, awareness, and perceptions (KAP) towards CC etiology, its signs and symptoms and risk factors among Health Professions Students’ (HPSs) in King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Jeddah Campus. Methods. Data was collected using predesigned and validated study questionnaire. The respondents’ KAP were compared across gender, colleges, and levels of education. Data analysis was done using SPSS v 20.0 (IBM Corporation) at 95% CI. Results. A total of 580 HPS responded to the survey, 128 (22.1%) were males, while 452 (77.9%) were females with the mean age ± SD 20.36 ± 1.74 years. Although 70% of the respondents had heard about CC, but only 27.9% and 18.6% knew that CC is common among women and it is transmissible, respectively. Additionally, the knowledge of relationship between viral infection and vaccination was also dismal (34.1%) and only 18.6% of the students had knowledge that CC was a transmissible disease. Interestingly, students from college of medicine had more knowledge and awareness about CC ( p < 0.05 ). Conclusions. Since HPSs had considerable low knowledge about CC, we identify the dire need to implement an effective education programs, curricular activities, and awareness campaigns for HPSs as well as general population to augment the learning process effectively.