King Of Medicine Research Articles

Transcriptomic Analysis Under Drought and Salt Stress Provides Insight into Genes Putatively Involved in Ginsenoside Biosynthesis in Panax japonicus Meyer.

Panax japonicus Meyer, a perennial herb of the dicotyledonaceae family Araliaceae, is a rare folk traditional Chinese medicine, known as "the king of herbal medicine" in China. To understand the genes involved in secondary pathways under drought and salt stress, the transcriptomic analysis of P. japonicus is of vital importance. The transcriptome of underground rhizomes, stems, and leaves under drought and salt stress in P. japonicus were performed using the Illumina HiSeq platform. After de novo assembly of transcripts, expression profiling and identified differentially expressed genes (DEGs) were performed. Furthermore, putative functions of identified DEGs correlated with ginsenoside in P. japonicus were explored using Gene Ontology terms and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway enrichment analysis. A total of 221,804 unigenes were obtained from the transcriptome of P. japonicus. The further analysis revealed that 10,839 unigenes were mapped to 91 KEGG pathways. Furthermore, a total of two metabolic pathways of P. japonicus in response to drought and salt stress related to triterpene saponin synthesis were screened. The sesquiterpene and triterpene metabolic pathways were annotated and finally putatively involved in ginsenoside content and correlation analysis of the expression of these genes were analyzed to identify four genes, β-amyrin synthase, isoprene synthase, squalene epoxidase, and 1-deoxy-D-ketose-5-phosphate synthase, respectively. Our results paves the way for screening highly expressed genes and mining genes related to triterpenoid saponin synthesis. It also provides valuable references for the study of genes involved in ginsenoside biosynthesis and signal pathway of P. japonicus.

Computational Evidence for the Anticancer Activity of Phytochemical Constituents of Terminalia Chebula: An In‐Silico Attempt

AbstractNatural compounds represent Secondary metabolites shaped and endorsed by nature over countless years, showcasing both unique chemical variety and a corresponding range of bioactivities, along with drug‐like attributes. Plant‐derived remedies are projected to comprise approximately 25 % of pharmaceuticals in developed nations. Terminalia chebula earns its title as the “King of medicines” due to its multifaceted pharmacological properties. The phytochemical elements within Terminalia chebula were assessed for their interaction with the human dihydrofolate reductase enzyme (5HT4.pdb) due to its significant role in the development of colorectal cancer. The American Cancer Society provides updated CRC statistics based on incidence from population‐based cancer registries and mortality from the National Center for Health Statistics. In 2023, approximately 153,020 individuals will be diagnosed with CRC and 52,550 will die from the disease, including 19,550 cases and 3750 deaths in individuals younger than 50 years. The compounds TC2 (−8.61 Kcal/mol), TC15 (−7.02 Kcal/mol), and TC23 (−6.98 Kcal/mol) demonstrated higher glide scores. Additionally, TC2 (−71.21 Kcal/mol), TC12 (−101.63 Kcal/mol), TC15 (−81.40 Kcal/mol), and TC29 (−77.47 Kcal/mol) exhibited stronger binding affinities (ΔG Bind) to the target. Based on the outcomes of both docking and MM‐GBSA analyses, TC2 was selected for further investigation via molecular dynamics (MD) simulations, which illustrated the stability of the TC2/5HT4 complex. Among the top‐ranked compounds, TC2 adhered to Lipinski's guidelines for drug‐likeness without any violations. Inhibiting the human DHFR enzyme indirectly hampers the progression of colon cancer. The findings from this in‐silico investigation serve as a foundational basis for potential in vitro and in vivo research.

The King of Chinese Medicine——Glycyrrhiza glabra (Licorice): All-round Inquiry in its Chemical Composition, Pharmacodynamics, Traditional and Medicinal Value

Licorice, a perennial herb of Leguminosa, is one of the oldest and most widely used herbal medicines worldwide. Its distinct sweet flavor and rich medicinal value make it an integral component of traditional Chinese medicine (TCM) formulations, which continue to be widely employed. The main chemical constituents of licorice include triterpenoid saponins, flavonoids, and polysaccharides. Experimental and clinical studies have demonstrated that various extracts and pure compounds derived from licorice exhibit a wide range of pharmacological properties including anti-inflammatory, antioxidant, antimicrobial, antiviral, antitumor, immune-regulatory, and neuroprotective activities. The bioactive constituents of licorice offer therapeutic benefits for cardiovascular and cerebrovascular diseases, diabetes mellitus, and liver disorders. This comprehensive review discusses the primary chemical constituents of licorice and their pharmacological activities, describes in vivo and in vitro models employed for studying licorice, and its potential targets and mechanisms of action. Furthermore, we discuss the toxicological profile, side effects, dosage recommendations, and clinical applications of licorice. This review aims to establish a foundation for further research on the safe and effective utilization of licorice while facilitating an in-depth exploration of its properties and fostering the development of novel therapeutic agents. Graphical abstract: http://links.lww.com/AHM/A102

Methods of extraction of bioactive compounds fromTerminalia Chebula(Haritaki) and their application in food and pharmaceutical industry: A review

AbstractMedicinal plants are an integral element of human society's effort to battle illness.Terminalia chebulaRetz. (Haritaki) is known in China as the “King of Medicine” and is usually at the top of the list of “Ayurvedic Material Medica” due to its incredible healing potential. The whole plant has great medicinal potential and has traditionally been used to cure a variety of human diseases. The global need for herbal medicines is continuously growing. For the most part, the Indian medical system relies on herbal remedies to treat illnesses. A significant number of pharmacological research on diverse medicinal plants have been done widely across the world where haritaki has been the subject of a lot of research in recent years. In addition, more research is needed to fully utilize its therapeutic potential in other medical conditions. More studies of this medication's bioactivity, mechanism of action, pharmacotherapeutics, toxicity, standardization, preclinical investigations, and clinical trials are needed for its global safe usage. In the present effort, chemical constituents, and bioactive properties of haritaki have been reviewed in detail with a brief description of extraction methods of bioactive compounds and applications.

Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis.

Panax ginseng is a medicinal plant belonging to the Araliaceae family. Ginseng is known as the king of oriental medicine, which has been practiced since ancient times in East Asian countries and globally in the modern era. Ginseng is used as an adaptogen, and research shows that it has several pharmacological benefits for various ailments such as cancer, inflammation, diabetes, and neurological symptoms. The pharmacological benefits of ginseng are attributed to the triterpenoid saponin ginsenosides found throughout the Panax ginseng species, which are abundant in its root and are found exclusively in P. ginseng and Panax quinquefolius. Recently, with the completion of the entire ginseng genome sequencing and the construction of the ginseng genome database, it has become possible to access information about many genes newly predicted to be involved in ginsenoside biosynthesis. This review briefly summarizes the current progress in ginseng genome analysis and genes involved in ginsenoside biosynthesis, proposing directions for functional studies of the predicted genes related to ginsenoside production and its regulation.

CONTRIBUTIONS OF MUSLIMS AND ISLAM IN THE DEVELOPMENT OF MEDICAL SCIENCE

Muslims have played very important role in the field of medical science. They began experiments and observations from the first century of Hijra. Islam created great enthusiasm for scientific activities. After extensive translation from Greek, Sanskrit and some other ancient languages into Arabic, Islamic physicians had at their disposal nearly all the valuable medical works, like Hippocratic and Galenic writings. Islamic physicians were immensely influenced by them, and largely depended on their studies as they considered them medical authorities. One of the important physicians in Islam was Avicenna (980-1037) the king of medicine. He had a great influence in the West and the East and was regarded as a medical authority until the era of medical studies. It was used as textbook in the West and East. Another Muslim physician in Islam who had great influence on later Ottoman physicians was Ibn al Nafis. In the 14th century Mansoor bin Muhammad composed a monograph on anatomy called" Illustrated Anatomy " By the eighth century, most of Europe was deep in the dark ages, with only the Byzantine Empire preserving a few fragments of the ancient knowledge. Islamic Caliphate provided a stable environment for Islamic Scholars, who were sponsored by the ruling class. Most Islamic scholars were free to undertake pure research. As with the Ancient Greeks, the Islamic observations on life were closely tied to philosophy and theology. There are so many Muslim scholars who contributed a lot in the field of medical Science and will be discussed in my research paper

The Effectiveness of Applying for Formative Assessment Objective Structured Clinical Examination (OSCE) for Undergraduate Students in Faculty of Medicine King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

The use of formative and summative assessment for students have been always a concern for medical professionals such as teachers and students especially when students are at graduating level. This can be supported with increasing the effectiveness and comprehensiveness of the students with appropriate clinical training using a defined structure with questionnaire-based system defined in the methodology to support student’s skills using clinical competencies to form perspective. It has been found that with Objective Structured Clinical Examination can be used as the method to assess the adequacy to support clinical skills of medical students following their competence level. This can be used to support a variety of tests to work on underpinning emergency procedures to interpret investigational data to ensure in-depth and breadth coverage of clinical skills following 5thyear medical students.

FACTORS INFLUENCING CHOOSING MEDICAL SPECIALTIES AMONG FINAL YEAR MALE STUDENTS AT KAU, JEDDAH, SAUDI ARABIA. A CROSS SECTIONAL STUDY

Background: Choosing a medical specialty is one of the challenging Aspect among medical students at their final academic year. This study aims to understand the factors influencing choosing medical specialties among medical students at King Abdulaziz University Methodology: An electronic questionnaire has been designed for data collection that involved 6th year medical students at faculty of medicine King AbdulazizUniversity . And chi-square test used to compare between different variables regarding the choice of medical fields Result: Of the 150 students approached, 45(30%) decided to participate. A total of (80%) students made a decision regarding their choice of future medical specialty. Internal medicine, psychiatry , orthopedic and diagnostic radiology were the most desired specialties(20%), (8.9%),(6.7) and (6.7%) students requested these specialties, respectively. Only (77,8%) of those who selected a future specialty received advice regarding their choice. was the good lifestyle (22.2%), followed by the good treatment outcome (20%) and thirdly is the verity of subspecialty with (15.6%) of student.

Clinical Application of Haritaki (Terminalia Chebula Retz.) in Ayurveda

Haritaki is the herb that has been used since ancient times as a long-time staple of the Ayurvedic practice. It is often called as King of Medicine. Haritaki is traditionally used as a remedy for all Vata disturbances, including constipation, emaciation, flatulence and indigestion. While Haritaki is so well known for its rasayana property, it is actually Tridosha shamaka, as it helps bring balance to all three Doshas. As a natural laxative and purgative, it removes undigested food and accumulated toxins from the gastrointestinal tract. It strengthens and nourishes the tissues and supports proper function of the colon, lungs, liver and spleen. Haritaki is highly revered in India, as it is believed to increase energy, intelligence and awareness. A narrative review was done in order to explore the properties of haritaki from the Ayurvedic texts. The review revealed that not only haritaki can be used with the mentioned additives (anupana), but many other combinations can be made for different diseased conditions. The review also includes the uses of haritaki in wide range of diseases as per the clinical experiences of the author.

A review on pharmacological activity of Terminalia chebula

Since the beginning of civilization, people have used medicinal herbs to treat illnesses. Medicinal plants, which are valued as plentiful sources of folk medicine, are the source of many contemporary pharmaceuticals. is used in several ayurvedic formulations and may have therapeutic benefits. Retz. (Family Combretaceae) is frequently at the top of the list of "Ayurvedic Materia Medica" and is referred to as the "King of Medicine" in Tibet due to its exceptional healing abilities, popularly referred to as "Harar". The entire plant is very restorative and has historically been used to treat a variety of human illnesses. Folklore claims that this plant was used to heal a variety of ailments, including gout, asthma, sore throats, bleeding piles, ulcers, hiccoughs, diarrhoea, and dysentery. Numerous pharmacological and therapeutic actions of the plant have been identified, including anti-inflammatory, anti-mutagenic, anti-proliferative, radioprotective, cardioprotective, anti-arthritic, and qualities that increase gastrointestinal motility. We have looked into the phyto-pharmacological characteristics of the plant and compiled its varied pharmacological uses in this review in order to comprehend and synthesise the issue of potential role as a multifunctional therapeutic agent.

The 2022 Wakley–Wu Lien Teh Prize Essay: compassion and connection in China

More than 1300 years ago, the physician Sun Simiao, who is known as “China's King of Medicine”, described in On the Absolute Sincerity of Great Physicians (often called the Chinese Hippocratic Oath) that a great physician must develop a heart full of great compassion and empathy and vow to alleviate suffering.1 Today, despite the rapid growth of cutting-edge technology in medicine, the core values of being a great physician in China remain as Sun Simiao defined.

Diagnostic Analysis of Electrolytes (NA+, k+, CL-, MG+2 and PO-34) in Cadaveric Synovial Fluid from Knee Joint to Estimate Postmortem Interval

Accurate determination of Time since death (TSD) has always been a challenge to forensic pathologists. Due to non-precise results using physical methods to estimate time of death, focus has been shifted to biochemical methods using body fluids. Previously, body fluids like cerebrospinal fluid (CSF) and vitreous humour have been used to determine postmortem interval (PMI), but in cases of head and ocular injuries respectively, they can be rendered useless. Synovial fluid is a well-preserved, compartmentalized fluid and hence, can be used to estimate PMI. The aim of this study was to determine death interval based on synovial fluid electrolytes levels (Na+, K+, Cl-, Mg+2, PO-34) and to assess its reliability for future studies. Study design: It was a correlational study. Study settings: The research was conducted at department of Forensic Medicine King Edward Medical University, Mayo Hospital Lahore, from August 2018 to August 2019. Methodology: PMI was regressed on synovial fluid electrolytes and regression formulae were formulated. Significant positive correlation was found between time since death and K+ ion concentration using regression formula. Results: However, there was negative relationship between PMI and Na+ and no significant relationship was found between TSD and Cl-, Mg+2 and PO-34 concentrations. The regression model of K+ gave a 97.9% accuracy and a correlation coefficient of 0.978 which showed the model using K+ values in synovial fluid is the most accurate one. Conclusion: The concentration of potassium ions increases with increasing time of death whereas, that of sodium decreases with increasing PMI. However, magnesium, chloride and phosphate concentrations remain unchanged with time interval. Keywords: sodium, magnesium, chloride, phosphate, electrolytes, synovial fluid

Anxiolytic-like and antidepressant-like effects of ethanol extract of Terminalia chebula in mice

Terminalia chebula (T.chebula) fruit is referred as “King of Medicines” in Tibet and is listed as a key plant in “Ayurvedic Materia Medica” due to its diverse pharmacological activity. The present study was aimed to investigate the comorbid antidepressant-like and anxiolytic-like effects of ethanol extract from T.chebula fruit using experimental behavioral tests in mice. In addition, the study explored the effects of extract on monoamine oxidase –A (MAO-A) levels in mouse brain. Two doses of the T.chebula extract (100 or 200 mg/kg, p.o.) were treated continuously for fifteen days to mice. Regarding antidepressant-like effects, the treatment of T.chebula extract at both dose (100 or 200 mg/kg, p.o.) levels resulted with significant (p < 0.001) reduction in duration of immobility time and increase in swimming time as compared to control group in forced swimming test. Moreover, both doses declined the duration of immobility time in the tail suspension test and increased the number of crossing in the center area using open-field test. Additionally, the dose 200 mg/kg treatment showed a significant reduction (p < 0.05) in MAO-A activity in mouse brain. For anxiolytic activity, both doses significantly (p < 0.001) improved the time spent in open arm and the number of head dips in elevated plus maze test. The higher duration of time spent in light chamber and higher number of crossing between the light and dark chambers by extract treatment in light-dark box test also supported the anxiolytic behavior. The obtained results supported the antidepressant-like and anxiolytic-like effects of ethanol extract of T.chebula in mice.

REVIEW OF HARITAKI (TERMINALIA CHEBULA Retz.) AS AN EKAL DRAVYA CHIKITSA IN BRIHATRAYEE

Ayurveda is a traditional system of Indian medicine which aims to promote health and wellness by maintaining equilibrium of all three Dosas of body. Natural medicinal herbs are an important component of this science which aims to protect the body from various ailments and offer an user a variety of health benefits including physical as well as mental health. Haritaki has been placed in high esteem among all medicinal herbs due to its rich property to prevent and cure disease. It is always listed first in Ayurveda as it is called the king of medicines due to its large number of uses having extraordinary therapeutic benefits. Since ancient time, Haritaki has enjoyed a prime place among all medicinal plants. It is being found to be used in many of compound formulations due to its wide spectrum of pharmacological activities. Haritaki is one of three dried fruits that make up the Ayurvedic formula Triphala. It has been used among the large number of population to promote healing from variety of diseases ranging from use as Rasayan to the diseases related to indigestion and many more. Haritaki is being used as a best prescribed remedy for many of the common ailments in day today’s life by large number of physician. It is being used easily in all diseases, either for its health promoting benefit or for its disease alleviating property. Nowadays, using Haritaki as a single Dravya with various Anupaan is a great trend giving optimum results. Ekaldravya concept of using single substances has been mentioned in our ancient Ayurvedic literature. Use of Haritaki as a single drug therapy has been evidenced at various instances in Brihatrayee.

Isolation and Identification of Multi-drug Resistant Bacteria from various sources and Antimicrobial Activity of Terminalia chebula Retz against isolated Multi-drug Resistant Bacteria

Drug resistance is a threat to civilization, which results from over-prescription and irrational use of antibiotics. This has led to an increased demand for novel leads of herbal origin to overcome drug resistance. The present work involves the screening of various antibiotics against isolated Staphylococcus sp. from Hospital Effluent and the Minimum Inhibitory concentration for antibiotics namely Vancomycin, Erythromycin and Oxacillin were found to be 7.33+0.6 µg/ml 25.33+0.6 µg/ml and 27.33+0.6 µg/ml respectively whereas Minimum bactericidal concentration of Vancomycin, Erythromycin and oxacillin was found to be 180µg/ml; 146.67 + 0.3 µg/ml and 96.66 + 0.6 µg/ml respectively. Thus, the isolated bacteria were proved to be Multi-Drug Resistant. Haritaki (Terminalia chebula Retz) is given potential importance in Ayurveda for its properties to cure and prevent diseases. Terminalia chebula Retz is often known as “King of Medicines” and enlisted in Ayurveda for its extraordinary therapeutic contribution. The proved Multi-Drug Resistant bacteria was further subjected to a crude extract of Haritaki. Minimum Inhibitory Concentration for Terminalia chebula was found to be 1.33 +0.3 mg/ml and thus proved to be exhibiting potential anti-bacterial activity against isolated Multi-Drug Resistant Staphylococcus sp.

A Review Article on Various Phytochemicals and Different Medicinal Activities of Haritaki.

Medicinal plant and plant products play very important role within the human culture to fight against ailments from the beginning of development [1].The application of herbal medicine in prevention and curing of ailments practiced from many years and also now in present time the Ayurveda medical system is reached everywhere in the globe, and it's well accepting by the people [2]. The home grown medication Haritaki (Terminalia Chebula Retz.) has a place with Combretaceae family and Used from crude time for restorative purposes [3]. Medicinal plant Haritaki is known as ' medicine king ' in country Tibet from numerous years back and It is constantly fixed it’s place at the head of the record of 'Ayurveda Materia Medica' because of containing remarkable ability of recuperating with a huge range of biological activity [3, 4]. In Ayurveda Haritaki (Terminalia Chembula Retz.) is one of the most frequently used herbal drug, act as a foundation and additive natural remedy with mild Colonic Cleanse properties and It can be taken daily without except any ill effects and with great Benefits [5]. It keeps equilibrium in three doshas, Purification the channels along with nourishes all the dhatus of the body [6]. Ayurveda clinical Science Underline it's activity as Used in different sicknesses like Poor digestion (Agnimandya), Irritable bowel syndrome (Grahni), Constipation (Vibandha), Malaria (Vishamjwara), Gulma, Juandice (Kamla), Cough (Kasa), Skin disease (Kustha), stone (Ashmari) etc and also having the properties of Rejuvenating (Rasayan) and Age delaying (Vayasthapka) [6].In Contemporary, studies proved that, it displays a different number of pharmacological exercises like Antidiabetic activity,Radio-protective activity, Antiplasmodic activity, wound healling activity, Antiulcerogenic activity, Antioxidant and free radical scavenging activity, antibacterial, antiviral, antifungal, anticancerous, Antimutagenic, cardio-protective [7, 6, 5, 4, 3, 2, 1]

THE EFFECT OF GENERAL LIFE STYLE BEHAVIOUR ON LIPID PROFILE OF BLOOD DONORS: TO IMPROVE QUALITY OF BLOOD SUPPLY IN BLOOD BANKS

Aim: Hyperlipidemia are thought to be a risk factors for cardiovascular disease (CVD) which are a major cause of death in India and worldwide which could be affected by lifestyle behavior including physical activity, sedentary life style and weight. Hyperlipidemia could hampers blood supply and blood products so donor selection and screening could be done for hyperlipidemia as donor selection and screening is important steps for the safety of blood transfusion procedure. The aim of the present study was to investigate the association of hyperlipidemia with donor criteria with their life style parameters. Subject and Methods: The present research was a cross-sectional study based on voluntary blood donation from Dec 2016-Dec2017. 300 fasted samples of blood donors were collected from Department of Transfusion Medicine King George’s Medical University Lucknow. Lipid profile analysis was performed at Department of Biochemistry King George’s Medical University, Lucknow. Results: Results summarized as significant association (p

The activity of Terminalia chebula Retz. extract on doxorubicin-induced renal damage in rats

Context: Doxorubicin (DXR) is a common anticancer drug known to produce several complications. Terminalia chebula popularly known as ‘King of medicine’ is found to possess wound healing, anti-inflammatory and antioxidant properties. Aims: To evaluate the effects of Terminalia chebula extract on doxorubicin-induced renal damages in rats. Methods: Coadministration of Terminalia chebula extract (0.25, 0.5 and 1.0 g/kg) was tested against DXR (2.5 mg/kg) induced renal damages in rats. Additional two groups were evaluated by administering 0.5 g/kg of the extract to animals either before or after DXR treatment. Kidney function tests were performed by measuring the serum levels of urea, creatinine, uric acid, and total protein. The antioxidant activity of the extract was evaluated by in vivo and in vitro methods. Histopathology of kidney tissues was performed to assess the morphological changes. The significance of results obtained were statistically analyzed. Results: The data obtained indicated that co-administration of the extract at higher doses (0.5 and 1.0 g/kg) significantly (p&lt;0.01) reduces the serum levels of creatinine, urea, uric acid, and total proteins compared to DXR group. The extract also decreases the structural damages induced by DXR and exhibited antioxidant property. However, the pre- and post-treatments of Terminalia extract neither alter significantly the biomarker levels nor ameliorated the histopathological changes induced by DXR in rats. Conclusions: The observations indicated that co-administration of Terminalia chebula decreased the renal damage induced by DXR in rats. The protective action of the extract may be related to its wound-healing and antioxidant properties, the latter of which diminished the free-radical damage induced by DXR.

Phytochemical and Pharmacological Profile of Terminalia chebula

Plant secondary metabolites have been of interest to man for a long time due to their pharmacological relevance. In this search Terminalia chebula is widely used to enhance the natural resistance to various diseases. It is called the “king of medicines” and always listed first in the Ayurvedic meteria medica because of its extraordinary powers of healing. Traditionally it has been used as a popular folk medicine for homeostatic, antitussive, laxative, diuretic and cardio tonic treatments. Recent studies showed that it has also been used as antidiabetic, antiviral, cardioprotective, anticancer, antioxidant, free radical scavenging and hypolipidemic agent. The present review is an attempt to highlight the various ethnopharmacological and traditional uses as well as phytochemical and pharmacological aspect of Terminalia chebula.

Screening of potential antiandrogenic phytoconstituents and secondary metabolites of Terminalia chebula by docking studies

Terminalia chebula (Haritaki) is known as the “King of Medicines” in Tibet because of its extraordinary powers of healing. It is extensively used in ayurveda, unani and homoeopathic medicine. It is listed first in Ayurvedic literatures due to its multifarious use in treating diseases. However continuous usage of this herb was known to cause decrease in sexual strength and infertility problems in males. Around 150 phytoconstituents have been isolated and characterised from T. chebula having various pharmacological activities. Some of the characterized compounds from T. chebula esp. the flavonoids and phenolics were found to have either antiestrogenic or antiandrogenic effects. This points to the fact that such compounds can function as endocrine disruptors which limits the long term use of this wonder drug. In this study an attempt is made to screen the potential antiandrogenic compounds from T. chebula using molecular docking. Two classes of compounds viz. triterpenoids and ellagitannin metabolites that are known to act as antiandrogens were selected for docking. A total of 17 triterpenoids and 13 ellagitannin metabolites were docked to the three binding sites (viz. ABS, BF3 and AF2 sites) in LBD of Rat and Human AR using AutoDock Vina. Also known agonists and antagonists of AR were docked to the above mentioned binding sites to draw a comparison. Eventhough both triterpenoids and ellagitannin metabolites showed comparable affinity to the binding sites with respect to the reference antagonists, urolithins and its derivatives showed the best binding. This point to the possibility that urolithins and its derivatives can function as potent antiandrogens. At a time when urolithins and ellagitannins are rising as promising nutraceuticals, more studies have to be done on its long term endocrine disrupting effects to ensure safety.