Volume Expansion Kinetics Research Articles

Kinetics of volume expansion during a fluid challenge

According to Guyton and colleagues [1], expansion of blood volume can increase cardiac output (CO) in so far as the change in volume affects the mean systemic filling pressure (Pmsf). However, rapid stress relaxation occurs after acute intravascular volume expansion so that the effect of volume on Pmsf and CO may disappear after a few minutes. The objective of the present study is to describe the extent of the haemodynamic changes generated by a fluid challenge during 10 minutes on critically ill patients.

Kinetics of volume expansion during infusion of Ringer’s solution based on two volume model

Kinetics of volume expansion during infusion of Ringer’s solution based on two volume model

Kinetics of volume expansion during infusion of Ringer’s solution based on single volume model

In this work mathematical models were developed to represent the kinetics of volume changes of fluid spaces associated with infusion of Ringer’s solution. During infusion of Ringer’s solution, the human body is assumed to be characterized by the two-fluid space model which has second volume space in addition to the first volume so that fluid exchanges between these two spaces are possible. Various infusion types were tested to accommodate different medical situations. Volunteers were given Ringer’s solution and the changes in blood hemoglobin were detected. From the comparison with experimental data, the two-fluid space model was found to represent adequately the kinetics of human volume expansion during infusion of Ringer’s solution.