Abstract The present study investigates the scaling of a 3.3-kW laboratory scale combustor (baseline) to 25-kW using Detached Eddy Simulation (DES) with detailed chemistry. The combustor operates on syngas under atmospheric conditions. Two novel scaling criteria, namely, constant volume to jet momentum ratio (CM) and constant volume to jet kinetic energy ratio (CK) have been introduced and applied to the 3.3-kW combustor. Additionally, the constant velocity (CV) and constant residence time (CRT) scaling criteria have also been investigated for comparison. Flow, mixing, temperature, and their effect on the reaction zone and emissions have been compared for the scaled-up combustors with the laboratory scale combustor. The scaling criteria were observed to significantly influence the location and volumetric distribution of the reaction zone. In terms of performance parameters, the CV criterion entails the lowest pressure drop and CO emissions. The performance of the CK and CM criteria closely follows that of the CV criterion, thus offering a promising scaling methodology for reverse-flow combustors. The chamber scaled by the CRT criterion recorded the highest pressure drop and CO emissions. The insights from the present study will aid in sizing lab-scale combustors to industrial requirements.