Purpose: The impact of posterior edentulism on the management of temporomandibular disorders (TMD) remains unclear, with a paucity of studies examining the influence of posterior edentulism on TMD symptoms. The objective of this study is to investigate the relationship between posterior edentulism and bruxism, tinnitus, and depression in TMD patients and to compare treatment outcomes in two groups with and without posterior edentulism. Material and methods: In a quasi-experimental controlled trial, 26 patients with TMD participated in a six-week intervention, including manual therapy, massage, postural exercises and kinesio taping. The patients were divided into 13 in the posterior edentulous group and 13 in the full dentate group. The participants attended 12 physiotherapy sessions, twice a week, over six weeks. Outcome measures, including bruxism, tinnitus, joint clicking, Beck Depression Inventory, and cervical range of motion, were evaluated at baseline and the end of the six weeks. Results: The six-week physiotherapy program significantly improved bruxism, tinnitus, cervical range of motion, and depression (p