Background: Cerebral palsy is a neurological condition affecting children and adolescents, often resulting in hemiparesis and impaired upper limb functionality. Constraint-Induced Movement Therapy (CIMT) has shown promise in rehabilitation, and Kinesio Taping (KT) is increasingly considered for its potential benefits. This study explores the synergistic impact of CIMT and KT on upper limb function and muscle tone in this population, filling a critical gap in research. Objective: To investigate the combined effects of CIMT and KT on upper limb functionality and spasticity in children and adolescents with hemiparesis. Methods: A comprehensive randomized clinical trial adhering to CONSORT guidelines was conducted. Forty-six participants aged 6 to 17 years, diagnosed with hemiparesis due to cerebral palsy, were divided into two groups: CIMT-only and CIMT + KT. Baseline assessments included age, gender, stroke type, time since stroke, and initial upper limb function (FMA-UE, BBT, SF-36, MAS). CIMT sessions were conducted intensively over four weeks, with the CIMT + KT group additionally receiving KT application. Post-intervention assessments were conducted using the same measures. Results: Both the CIMT and CIMT + KT groups demonstrated significant improvements in the use of the affected limb for daily tasks, as indicated by the Motor Activity Log (MAL) scores. The CIMT-only Group showed a mean change in MAL score of 15.4 ± 8.1, while the CIMT + KT Group exhibited a mean change of 10.2 ± 6.5. Strong performance in upper limb functionality, assessed through the Wolf Motor Function Test (WMFT) Functional Ability Scale (FAS), was observed in both groups. The CIMT-only Group demonstrated a mean change in WMFT FAS score of 12.3 ± 6.2, and the CIMT + KT Group had a mean change of 8.4 ± 5.1. Additionally, both groups experienced a notable reduction in muscle tone, assessed using the Modified Ashworth Scale (MAS). The CIMT-only Group had a mean change in MAS score of -0.6 ± 0.4, while the CIMT + KT Group had a mean change of -0.4 ± 0.5. No statistically significant differences were observed between the two groups regarding the quality and quantity of movement. Conclusion: Integrating Kinesio Taping with Constraint-Induced Movement Therapy effectively reduces muscular tone in the wrist and fingers, enhancing upper limb functionality in children and adolescents with hemiparesis. While Kinesio Taping alone and in combination with CIMT demonstrates efficacy, further research is warranted to optimize therapeutic applications.