Among the neurodegenerative diseases, Parkinson’s disease (PD) is the most common movement disorder. In the literature, different approaches to analyse both upper and lower limbs motion patterns have been proposed [1,2]. Referring to our previous work [3], we demonstrated, after a statistical analysis, several features, extracted from upper limb reaching movements acquired through goniometric sensors, confirmed helpful in discriminating healthy controls and PD patients. Following these encouraging results, in this work we explored the possibility of using such features as input to two different machine learning (ML) algorithms and assessed their capability to distinguish healthy controls and PD patients. Twelve subjects (six health controls and six PD patients), who were admitted at the Institute of Care and Scientific Research of Telese Terme of ICS Maugeri SPA SB (Telese Terme, Italy), performed a kinematic task – made up of four movements through the upper limb – twice. The signals of such movements (consisting in an angular displacement) were acquired through a goniometric sensor. Later, thirteen statistical features were extracted through the custom-made software described in [3]. They were given as input to J48 and K Nearest Neighbour (KNN) and a leave one out cross-validation was implemented. Algorithms performance was assessed in terms of accuracy, sensitivity, specificity and Area Under the Curve Receiver Operating Characteristics (AUC-ROC). The classification algorithms achieved promising results, with metrics that overcame the value of 90%. The tree-based algorithm J48 achieved higher accuracy and sensitivity (91.7% and 100% respectively), while KNN achieved the highest specificity and AUC-ROC (91.7% and 0.94). Table 1 summarizes the results achieved by the algorithms. This paper answers to the need of defining measurable, repeatable, and reliable indicators to monitor the effectiveness of a training program over time; moreover, the paper provides a quantitative measure of the rehabilitation outcome, which is a necessary step towards the design of personalized treatment programs. The results obtained in this investigative research are promising and allow us to think about additional ML algorithms to be considered in further studies and to enlarge the ML approach by considering/investigating additional features to extract.
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